scholarly journals An Antagonistic Axon-Dendrite Interplay Enables Efficient Neuronal Repair in the Adult Zebrafish Central Nervous System

2018 ◽  
Vol 56 (5) ◽  
pp. 3175-3192 ◽  
Author(s):  
An Beckers ◽  
Annelies Van Dyck ◽  
Ilse Bollaerts ◽  
Jessie Van houcke ◽  
Evy Lefevere ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Adult Zebrafish ◽  
Neuronal Repair

Expression of protein zero is increased in lesioned axon pathways in the central nervous system of adult zebrafish

Glia ◽  
2003 ◽  
Vol 41 (3) ◽  
pp. 301-317 ◽  
Author(s):  
J�rn Schweitzer ◽  
Thomas Becker ◽  
Catherina G. Becker ◽  
Melitta Schachner
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Adult Zebrafish ◽  
The Central Nervous System ◽  
Protein Zero

scholarly journals Anxiolytic-like effect of natural product 2-hydroxy-3,4,6-trimethoxyacetophenone isolated from Croton anisodontus in adult zebrafish via serotonergic neuromodulation involvement of the 5-HT system

2021 ◽  
Author(s):  
Antonio Wlisses da Silva ◽  
Maria Kueirislene A. Ferreira ◽  
Emanuela L. Rebouças ◽  
Francisco Rogenio S. Mendes ◽  
Atilano Lucas dos S. Moura ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Locomotor Activity ◽  
Acute Toxicity ◽  
Natural Product ◽  
Anxiolytic Effect ◽  
Mechanisms Of Action ◽  
Anticonvulsant Effect ◽  
Adult Zebrafish ◽  
The Central Nervous System

Abstract Benzodiazepines are highly effective in combating anxiety; however, they have considerable adverse effects, so it is important to discover new safe anxiolytic agents. This study was designed to investigate the anxiolytic and anticonvulsant effect of natural product 2-hydroxy-3,4,6-trimethoxyacetophenone (HTMCX) and its possible mechanisms of action in adult zebrafish. The open field and light / dark tests (n = 6 animals/group) were used to assess anxiety and pentylenetetrazole (PTZ) as a seizure inducer. The 96-hour acute toxicity of HTMCX was also investigated. HTMCX (1, 3, and 10 mg / kg; v.o.) was not toxic and affected locomotor activity. The highest doses (3 and 10 mg / kg; v.o.) produced signs of anxiolytic action in the light / dark test, and this effect was abolished by the pizotifen (antagonist 5HTR1 and 5HTR2A / 2C), having the potential to form a complex in the same region of the site indicating that the anxiolytic effect via the serotonergic mechanism. However, the anxiolytic effect of HTMCX has not been abolished by flumazenil (antagonist GABARA), cyproheptadine (antagonist 5HTR2A), and granisetron (antagonist 5HTR3A / 3B). Therefore, HTMCX demonstrated an anxiolytic effect, suggesting that the 5HTR1 and 5HTR / 2C receptors may be involved in the pharmacological performance of this acetophenone in the central nervous system.

Radial glia and neural progenitors in the adult zebrafish central nervous system

Glia ◽  
2015 ◽  
Vol 63 (8) ◽  
pp. 1406-1428 ◽  
Author(s):  
Emmanuel Than-Trong ◽  
Laure Bally-Cuif
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Radial Glia ◽  
Neural Progenitors ◽  
Adult Zebrafish

scholarly journals Krüpple-like factors 7 and 6a mRNA expression in adult zebrafish central nervous system

2016 ◽  
Vol 21 (1) ◽  
pp. 41-53
Author(s):  
Sunil Bhattarai ◽  
Alicja Sochacka-Marlowe ◽  
Gerald Crutchfield ◽  
Ramisha Khan ◽  
Richard Londraville ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Mrna Expression ◽  
Adult Zebrafish

scholarly journals Topographical Analysis of Reactive Zinc in the Central Nervous System of Adult Zebrafish (Danio Rerio)

Zebrafish ◽  
2013 ◽  
Vol 10 (3) ◽  
pp. 376-388 ◽  
Author(s):  
Marcos M. Braga ◽  
Denis B. Rosemberg ◽  
Diogo L. de Oliveira ◽  
Cássio M. Loss ◽  
Sandro D. Córdova ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Danio Rerio ◽  
Adult Zebrafish ◽  
The Central Nervous System ◽  
Topographical Analysis

scholarly journals Anxiolytic-Like Effect of Natural Product 2-hydroxy-3,4,6-trimethoxyacetophenone Isolated From Croton Anisodontus in Adult Zebrafish via Serotonergic Neuromodulation Involvement of the 5-ht System

2021 ◽  
Author(s):  
Antonio Wlisses da Silva ◽  
Maria Kueirislene A. Ferreira ◽  
Emanuela L. Rebouças ◽  
Francisco Rogenio S. Mendes ◽  
Atilano Lucas dos S. Moura ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Locomotor Activity ◽  
Acute Toxicity ◽  
Natural Product ◽  
Anxiolytic Effect ◽  
Mechanisms Of Action ◽  
Anticonvulsant Effect ◽  
Adult Zebrafish ◽  
The Central Nervous System

Abstract Benzodiazepines are highly effective in combating anxiety; however, they have considerable adverse effects, so it is important to discover new safe anxiolytic agents. This study was designed to investigate the anxiolytic and anticonvulsant effect of natural product 2-hydroxy-3,4,6-trimethoxyacetophenone (HTMCX) and its possible mechanisms of action in adult zebrafish. The open field and light / dark tests (n = 6 animals/group) were used to assess anxiety and pentylenetetrazole (PTZ) as a seizure inducer. The 96-hour acute toxicity of HTMCX was also investigated. HTMCX (1, 3, and 10 mg / Kg; v.o.) was not toxic and affected locomotor activity. The highest doses (3 and 10 mg / Kg; v.o.) produced signs of anxiolytic action in the light / dark test, and this effect was abolished by the pizotifen (antagonist 5HTR1 and 5HTR2A / 2C), having the potential to form a complex in the same region of the site indicating that the anxiolytic effect via the serotonergic mechanism. However, the anxiolytic effect of HTMCX has not been abolished by flumazenil (antagonist GABARA), cyproheptadine (antagonist 5HTR2A), and granisetron (antagonist 5HTR3A / 3B). Therefore, HTMCX demonstrated an anxiolytic effect, suggesting that the 5HTR1 and 5HTR / 2C receptors may be involved in the pharmacological performance of this acetophenone in the central nervous system.

Neurotropic enteroviruses co-opt “fair-weather-friend” commensal gut microbiota to drive host infection and central nervous system disturbances

2019 ◽  
Vol 42 ◽  
Author(s):  
Kevin B. Clark
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gut Bacteria ◽  
Infection Cycle ◽  
Fair Weather ◽  
Host Health ◽  
Microbe Interactions ◽  
Animal Hosts ◽  
Host Infection ◽  
Neuropsychiatric Conditions

Abstract Some neurotropic enteroviruses hijack Trojan horse/raft commensal gut bacteria to render devastating biomimicking cryptic attacks on human/animal hosts. Such virus-microbe interactions manipulate hosts’ gut-brain axes with accompanying infection-cycle-optimizing central nervous system (CNS) disturbances, including severe neurodevelopmental, neuromotor, and neuropsychiatric conditions. Co-opted bacteria thus indirectly influence host health, development, behavior, and mind as possible “fair-weather-friend” symbionts, switching from commensal to context-dependent pathogen-like strategies benefiting gut-bacteria fitness.

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