Mesenchymal stem cells (MSCs) are a kind of adult stem cells with self-replication and multidirectional
differentiation, which can differentiate into tissue-specific cells under physiological conditions, maintaining
tissue self-renewal and physiological functions. They play a role in the pathological condition by lateral
differentiation into tissue-specific cells, replacing damaged tissue cells by playing the role of a regenerative medicine
, or repairing damaged tissues through angiogenesis, thereby, regulating immune responses, inflammatory
responses, and inhibiting apoptosis. It has become an important seed cell for tissue repair and organ reconstruction,
and cell therapy based on MSCs has been widely used clinically. The study found that the probability of
stem cells migrating to the damaged area after transplantation or differentiating into damaged cells is very low, so
the researchers believe the leading role of stem cell transplantation for tissue repair is paracrine secretion, secreting
growth factors, cytokines or other components. Exosomes are biologically active small vesicles secreted by
MSCs. Recent studies have shown that they can transfer functional proteins, RNA, microRNAs, and lncRNAs
between cells, and greatly reduce the immune response. Under the premise of promoting proliferation and inhibition
of apoptosis, they play a repair role in tissue damage, which is caused by a variety of diseases. In this paper,
the biological characteristics of exosomes (MSCs-exosomes) derived from mesenchymal stem cells, intercellular
transport mechanisms, and their research progress in the field of stem cell therapy are reviewed.