The Effects of Dormancy Status on the Endogenous Contents and Biological Activities of Jasmonic Acid, N-(jasmonoyl)-Isoleucine, and Tuberonic Acid in Potato Tubers

Cancer is a serious problem in modern medicine, mainly due to the insufficient effectiveness of currently available therapies. There is a particular interest in compounds of natural origin, which can be used in the prophylaxis, as well as in the treatment and support of cancer treatment. One such compound is jasmonic acid (3-oxo-2-(pent-2’-enyl)cyclopentane acetic acid; isolated active form: trans-(-)-(3R,7R)- and cis-(+)-(3R,7S)-jasmonic acid) and its derivatives, which, due to their wide range of biological activities, are also proposed as potential therapeutic agents. Therefore, a review of literature data on the biological activity of jasmonates was prepared, with particular emphasis on the mechanisms of jasmonate action in neoplastic diseases. The anti-tumor activity of jasmonate compounds is based on altered cellular ATP levels; induction of re-differentiation through the action of Mitogen Activated Protein Kinases (MAPKs); the induction of the apoptosis by reactive oxygen species. Jasmonates can be used in anti-cancer therapy in combination with other known drugs, such as cisplatin, paclitaxel or doxorubicin, showing a synergistic effect. The structure–activity relationship of novel jasmonate derivatives with anti-tumor, anti-inflammatory and anti-aging effects is also shown.

Download Full-text

Potential Acetylcholinesterase, Lipase, α-Glucosidase, and α-Amylase Inhibitory Activity, as well as Antimicrobial Activities, of Essential Oil from Lettuce Leaf Basil (Ocimum basilicum L.) Elicited with Jasmonic Acid

Applied Sciences ◽

10.3390/app10124315 ◽

2020 ◽

Vol 10 (12) ◽

pp. 4315 ◽

Cited By ~ 1

Author(s):

Urszula Złotek ◽

Kamila Rybczyńska-Tkaczyk ◽

Monika Michalak-Majewska ◽

Małgorzata Sikora ◽

Anna Jakubczyk

Keyword(s):

Jasmonic Acid ◽

Essential Oils ◽

Inhibitory Activity ◽

Biological Activities ◽

Control Sample ◽

Antimicrobial Activities ◽

Ocimum Basilicum ◽

Gram Negative Bacteria ◽

Gram Positive Bacteria ◽

Significant Difference

The aim of this study was to investigate the influence of the elicitation with jasmonic acid on the biological activities of essential oils (EOs) from lettuce leaf basil (Ocimum basilicum L.). Specifically, 0.01 µM jasmonic acid (JA1), 1 µM jasmonic acid (JA2), and 100 µM jasmonic acid (JA3) were used as elicitors. The results indicated that the elicitation increased the acetylcholinesterase, lipase, and α-amylase inhibitory activity of essential oils. A significant difference in α-glucosidase inhibition was noted only for the JA3 extract (IC50 = 0.81 µL/mL), as this activity was lower than in the control sample without elicitation (IC50 = 0.68 µL/mL). The studied basil EOs exhibited similar activity against Staphylococcus aureus (Gram-positive bacteria) and Escherichia coli (Gram-negative bacteria). Based on the value of the minimum inhibitory concentration (MIC) and the minimum bactericidal concentrations (MBC), the best antimicrobial activity was observed for JA2 and JA3.

Download Full-text

Wound-induced Accumulation of Jasmonic Acid in Tissues of Potato Tubers

Plant and Cell Physiology ◽

10.1093/oxfordjournals.pcp.a078653 ◽

1994 ◽

Vol 35 (5) ◽

pp. 751-756 ◽

Cited By ~ 16

Author(s):

Yasunori Koda ◽

Yoshio Kikuta

Keyword(s):

Jasmonic Acid ◽

Potato Tubers

Download Full-text