scholarly journals Transdermal Delivery of Ibuprofen Utilizing a Novel Solvent-Free Pressure-sensitive Adhesive (PSA): TEPI® Technology

2017 ◽  
Vol 13 (1) ◽  
pp. 48-57 ◽  
Author(s):  
Emma L. Tombs ◽  
Vasiliki Nikolaou ◽  
Gabit Nurumbetov ◽  
David M. Haddleton
Keyword(s):  
Transdermal Delivery ◽  
Solvent Free ◽  
Pressure Sensitive Adhesive ◽  
Pressure Sensitive

scholarly journals Synthesis of photoreactive solvent-free acrylic pressure-sensitive adhesives in the recovered system

2007 ◽  
Vol 9 (2) ◽  
pp. 5-9 ◽  
Author(s):  
Roland Milker ◽  
Zbigniew Czech ◽  
Marta Wesołowska
Keyword(s):  
Organic Solvent ◽  
Solvent Free ◽  
The Novel ◽  
Pressure Sensitive Adhesive ◽  
Adhesive Film ◽  
Pressure Sensitive Adhesives ◽  
Pressure Sensitive ◽  
Wide Range ◽  
Protective Films ◽  
New Type

Synthesis of photoreactive solvent-free acrylic pressure-sensitive adhesives in the recovered system The present paper discloses a novel photoreactive solvent-free acrylic pressure-sensitive adhesive (PSA) systems, especially suitable for the so much adhesive film applications as the double-sided, single-sided or carrier-free technical tapes, self-adhesive labels, protective films, marking and sign films and wide range of medical products. The novel photoreactive solvent-free pressure-sensitive adhesives contain no volatile organic compounds (residue monomers or organic solvent) and comply with the environment and legislation. The synthesis of this new type of acrylic PSA is conducted in common practice by solvent polymerisation. After the organic solvent are removed, there remains a non-volatile, solvent-free highly viscous material, which can be processed on a hot-melt coating machine at the temperatures of about 100 to 140°C.

scholarly journals FORMULATION ANDEVALUATION OF TRANSDERMAL DRUG DELIVERY OF TORASEMIDE

2016 ◽  
Vol 1 (03) ◽  
Author(s):  
Sanjay Kumar Yadav ◽  
Ravikant Gupta ◽  
S M Malipatil ◽  
S K Gupta
Keyword(s):  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Pressure Sensitive Adhesive ◽  
Skin Patch ◽  
Pressure Sensitive ◽  
Nutrient Patches ◽  
Inert Polymer ◽  
Transdermal Delivery System ◽  
Pass Through ◽  
Release Liner

A skin patch uses a special membrane to control the rate at which the liquid drug contained in the reservoir within the patch can pass through the skin and into the bloodstream. The basic components of any transdermal delivery system include the drug(s) dissolved or dispersed in a reservoir or inert polymer matrix; an outer backing film of paper, plastic, or foil; and a pressure-sensitive adhesive that anchors the patch to the skin. The adhesive is covered by a release liner, which needs to be peeled off before applying the patch to the skin. Drugs administered via skin patches include scopolamine, nicotine, estrogen, nitroglycerin, and lidocaine. Non-medicated patch markets include thermal and cold patches, nutrient patches, skin care patches (a category that consists of two major sub-categories-therapeutic and cosmetic), aroma patches, weight loss patches and patches that measure sunlight exposure.

scholarly journals Manufacturing of Solvent-Free Acrylic Pressure-Sensitive Adhesives in Form of Self-Adhesive Layers

2013 ◽  
Vol 13 ◽  
pp. 147-159 ◽  
Author(s):  
Zbigniew Czech ◽  
Dominika Sowa ◽  
Paulina Ragańska
Keyword(s):  
Solvent Free ◽  
Polymerization Process ◽  
Pressure Sensitive Adhesive ◽  
Adhesive Layers ◽  
Pressure Sensitive Adhesives ◽  
Uv Crosslinking ◽  
Pressure Sensitive ◽  
New Synthesis ◽  
Technical Specifications ◽  
New Applications

The present publication is related to a process for producing the non-solvent acrylic pressure-sensitive adhesive (PSA). New applications and technical specifications stimulate the continuous development of new methods of polymerization of solvent-free acrylate. New synthesis of solvent-free acrylics includes polymerization in the reactor with removal of the solvent and polymerization of the carrier. The polymerization process is connected with UV-crosslinking.

scholarly journals Effect of Different Pressure-Sensitive Adhesives on Performance Parameters of Matrix-Type Transdermal Delivery Systems

Pharmaceutics ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 209 ◽  
Author(s):  
Behnam Dasht Bozorg ◽  
Ajay K. Banga
Keyword(s):  
Transdermal Delivery ◽  
Drug Loading ◽  
In Vitro Release ◽  
Systemic Circulation ◽  
Delivery Systems ◽  
Pressure Sensitive Adhesive ◽  
Matrix Type ◽  
Pressure Sensitive ◽  
Percentage Release

Matrix-type transdermal delivery systems (TDS) are comprised of the drug dissolved or dispersed in a pressure-sensitive adhesive (PSA) matrix and are designed to provide a controlled delivery through the skin and into systemic circulation. PSAs can directly affect the permeation, release, and performance characteristics of the system. In this study we aimed to design and characterize transdermal delivery systems formulated with lidocaine—as the model drug—loaded in different PSAs, including silicone, polyisobutylene (PIB), and acrylate. TDS containing lidocaine at its saturation points were prepared by the solvent casting method. In vitro permeation studies across dermatomed porcine ear skin were performed using Franz diffusion cells. In vitro release studies were carried out using USP apparatus 5 (paddle over disk). The cumulative amount permeated from the acrylate was significantly higher than silicone and PIB. The acrylate TDS contained a ten times higher drug amount than silicone TDS, but the permeation flux was only two folds higher. Results also showed the release of drug does not linearly correlate to saturation, as the silicone TDS comprising of the lowest amount of drug loading, showed the highest percentage release indicating the choice of PSA affected the drug release and permeation profile.

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