Pressure Sensitive Adhesive for 6‐Mercaptopurine Transdermal Delivery for Solid Tumor in Mice

2007 ◽  
Vol 45 (1) ◽  
pp. 93-99
Author(s):  
N. S. Chandrashekar ◽  
R. H. Shobha Rani
Keyword(s):  
Solid Tumor ◽  
Transdermal Delivery ◽  
Pressure Sensitive Adhesive ◽  
Pressure Sensitive

scholarly journals FORMULATION ANDEVALUATION OF TRANSDERMAL DRUG DELIVERY OF TORASEMIDE

2016 ◽  
Vol 1 (03) ◽  
Author(s):  
Sanjay Kumar Yadav ◽  
Ravikant Gupta ◽  
S M Malipatil ◽  
S K Gupta
Keyword(s):  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Pressure Sensitive Adhesive ◽  
Skin Patch ◽  
Pressure Sensitive ◽  
Nutrient Patches ◽  
Inert Polymer ◽  
Transdermal Delivery System ◽  
Pass Through ◽  
Release Liner

A skin patch uses a special membrane to control the rate at which the liquid drug contained in the reservoir within the patch can pass through the skin and into the bloodstream. The basic components of any transdermal delivery system include the drug(s) dissolved or dispersed in a reservoir or inert polymer matrix; an outer backing film of paper, plastic, or foil; and a pressure-sensitive adhesive that anchors the patch to the skin. The adhesive is covered by a release liner, which needs to be peeled off before applying the patch to the skin. Drugs administered via skin patches include scopolamine, nicotine, estrogen, nitroglycerin, and lidocaine. Non-medicated patch markets include thermal and cold patches, nutrient patches, skin care patches (a category that consists of two major sub-categories-therapeutic and cosmetic), aroma patches, weight loss patches and patches that measure sunlight exposure.

scholarly journals Effect of Different Pressure-Sensitive Adhesives on Performance Parameters of Matrix-Type Transdermal Delivery Systems

Pharmaceutics ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 209 ◽  
Author(s):  
Behnam Dasht Bozorg ◽  
Ajay K. Banga
Keyword(s):  
Transdermal Delivery ◽  
Drug Loading ◽  
In Vitro Release ◽  
Systemic Circulation ◽  
Delivery Systems ◽  
Pressure Sensitive Adhesive ◽  
Matrix Type ◽  
Pressure Sensitive ◽  
Percentage Release

Matrix-type transdermal delivery systems (TDS) are comprised of the drug dissolved or dispersed in a pressure-sensitive adhesive (PSA) matrix and are designed to provide a controlled delivery through the skin and into systemic circulation. PSAs can directly affect the permeation, release, and performance characteristics of the system. In this study we aimed to design and characterize transdermal delivery systems formulated with lidocaine—as the model drug—loaded in different PSAs, including silicone, polyisobutylene (PIB), and acrylate. TDS containing lidocaine at its saturation points were prepared by the solvent casting method. In vitro permeation studies across dermatomed porcine ear skin were performed using Franz diffusion cells. In vitro release studies were carried out using USP apparatus 5 (paddle over disk). The cumulative amount permeated from the acrylate was significantly higher than silicone and PIB. The acrylate TDS contained a ten times higher drug amount than silicone TDS, but the permeation flux was only two folds higher. Results also showed the release of drug does not linearly correlate to saturation, as the silicone TDS comprising of the lowest amount of drug loading, showed the highest percentage release indicating the choice of PSA affected the drug release and permeation profile.

Passivation of pressure sensitive adhesive stickies by addition of acrylic fibers to OCC pulp before papermaking

TAPPI Journal ◽  
2016 ◽  
Vol 15 (10) ◽  
pp. 631-639
Author(s):  
MOHAMMAD HADI ARYAIE MONFARED ◽  
HOSSEIN RESALATI ◽  
ALI GHASEMIAN ◽  
MARTIN A. HUBBE
Keyword(s):  
Adverse Effects ◽  
Control Sample ◽  
Pressure Sensitive Adhesive ◽  
Acrylic Fiber ◽  
Burst Strength ◽  
Pressure Sensitive Adhesives ◽  
Pressure Sensitive ◽  
Tear Index ◽  
Breaking Length ◽  
Acrylic Fibers

This study investigated the addition of acrylic fiber to old corrugated container (OCC) pulp as a possible means of overcoming adverse effects of water-based pressure sensitive adhesives during manufacture of paper or paperboard. Such adhesives can constitute a main source of stickies, which hurt the efficiency of the papermaking process and make tacky spots in the product. The highest amount of acrylic fiber added to recycled pulps generally resulted in a 77% reduction in accepted pulp microstickies. The addition of acrylic fibers also increased pulp freeness, tear index, burst strength, and breaking length, though there was a reduction in screen yield. Hence, in addition to controlling the adverse effects of stickies, the addition of acrylic fibers resulted in the improvement of the mechanical properties of paper compared with a control sample.

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