Controlled SrR Delivery by the Incorporation of Mg Particles on Biodegradable PLA-Based Composites

Among several ions playing a vital role in the body, Sr2+ and Mg2+ are involved in the mechanism of bone formation, making them especially useful for bone tissue engineering applications. Recently, polylactic acid (PLA)/Mg composites have emerged as a promising family of biomaterials due to their inherent biocompatibility and biodegradability properties. In these composites, polymer and bio-metal have a synergetic effect—while the PLA inhibits the Mg fast reactivity, Mg provides bioactivity to the inert polymer buffering the medium pH during degradation. Meanwhile, the typical form of administrating Sr2+ to patients is through the medication strontium ranelate (SrR), which increases the bone mineral density. Following this interesting research line, a new group of composites, which integrates Mg particles and SrR charged onto halloysite nanotubes (HNT) in a polymeric matrix, was proposed. PLA/Mg/SrR–HNT composites have been processed following a colloidal route, obtaining homogenous composites granulated and film-shaped. The drug delivery profile was evaluated in terms of in vitro lixiviation/dissolution paying special attention to the synergism of both ions release. The combination of two of the most reported ions involved in bone regeneration in the composite biomaterial may generate extra interest in bone healing applications.

3D Printing of Cell Culture Devices: Assessment and Prevention of the Cytotoxicity of Photopolymers for Stereolithography

3D printing is increasingly important for the rapid prototyping of advanced and tailor-made cell culture devices. In this context, stereolithography represents a method for the rapid generation of prototypes from photocurable polymers. However, the biocompatibility of commercially available photopolymers is largely unknown. Therefore, we evaluated the cytotoxicity of six polymers, two of them certified as biocompatible according to ISO 10993-5:2009, and we evaluated, if coating with Parylene, an inert polymer widely used in medical applications, might shield cells from the cytotoxic effects of a toxic polymer. In addition, we evaluated the processability, reliability, and consistency of the details printed. Human mesenchymal stem cells (MSCs) were used for cytotoxicity testing as they are widely used and promising for numerous applications in regenerative medicine. MSCs were incubated together with printed photopolymers, and the cytotoxicity was assessed. All photopolymers significantly reduced the viability of MSCs while the officially biocompatible resins displayed minor toxic effects. Further, coating with Parylene completely protected MSCs from toxic effects. In conclusion, none of the tested polymers can be fully recommended for rapid prototyping of cell culture devices. However, coating with Parylene can shield cells from toxic effects and thus might represent a viable option until more compatible materials are available.

Development of Inert, Polymer-Bonded Simulants for Explosives Detection Systems Based on Transmission X-ray

Explosives detection systems (EDS) based on X-ray are used at airports to screen baggage for the presence of explosives. In Europe and the United States, EDS equipment is tested extensively by specialist test centres prior to approval for operational use in airports. Once EDS are installed in airports, however, it can be challenging to test the EDS equipment and verify that it continues to perform at the highest level, because of the impracticality of introducing bulk explosives into civil aviation airports. We have developed inert, non-toxic polymer-bonded simulants and validated them against real explosives using EDS equipment. The accuracy of our simulants is within 1% of the target bulk density, and within 2% of the target effective atomic number, and the materials have a stability of at least 4 years, with an uncertainty of 0.5%. The simulants generate alarms in almost 100% of cases on a wide range of commercial EDS models, and we consider the simulants fit for purpose for use during testing of EDS equipment at airports.

Mechanistic insight into the improved Li ion conductivity of solid polymer electrolytes

The studies shown here prove that both the Li salt and ‘inert-polymer’ mixing have paramount importance in the tunability of Li ion conductivity in solid electrolytes for batteries.

Making strong polyelectrolyte brushes pH-sensitive by incorporation of gold nanoparticles

Incorporation of pH-sensitive gold nanoparticles in an inert polymer brush triggers a pH-sensitive response.

Bio-activation of Inert pHEMA Matrices with Phosphate Loaded Cellulose Fibers in Order to Induce Mineralization

Luffa cylindrica fibers were purified through alkaline treatment and loaded with phosphate as mineral precursor. Their capacity of acting as bioactivator for an inert polymer was evaluated. In this respect, the PO43- - Luffa fibers were loaded in a polymeric matrix known not to promote biomineralization through immersion in mineralization media. The synthesized materials were subjected to alternative Ca/P baths and the formation of mineral was investigated through SEM. Also, the mechanical properties and the water affinity of the un-mineralized and mineralized materials were investigated.