Screening of Selective C16 to C18 Lipids and Process Optimization Based on Design of Experiments in Formulating Solid Lipid Microparticles by Twin Screw Hot Melt Dispersion Process

2021 ◽  
Author(s):  
Rajkiran G. Narkhede ◽  
Rajani B. Athawale
Keyword(s):  
Design Of Experiments ◽  
Process Optimization ◽  
Dispersion Process ◽  
Solid Lipid ◽  
Solid Lipid Microparticles ◽  
Twin Screw ◽  
Lipid Microparticles ◽  
Hot Melt

Development, in vitro and in vivo Evaluations of Solid-Lipid Microparticles based on Solidified Micellar Carrier System for Oral Delivery of Cefepime

2017 ◽  
Vol 10 (1) ◽  
pp. 3582-3593
Author(s):  
Chukwuebuka Umeyor ◽  
Uchechukwu Nnadozie ◽  
Anthony Attama
Keyword(s):  
Oral Delivery ◽  
In Vitro Release ◽  
Carrier System ◽  
Solid Lipid ◽  
Solid Lipid Microparticles ◽  
Release Study ◽  
Lipid Microparticles ◽  
Vitro Release

This study seeks to formulate and evaluate a solid lipid nanoparticle-based, solidified micellar carrier system for oral delivery of cefepime. Cefepime has enjoyed a lot of therapeutic usage in the treatment of susceptible bacterial infections; however, its use is limited due to its administration as an injection only with poor patient compliance. Since oral drug administration encourage high patient compliance with resultant effect in improved therapy, cefepime was formulated as solid lipid microparticles for oral delivery using the concept of solidified micellar carrier system. The carrier system was evaluated based on particle yield, particle size and morphology, encapsulation efficiency (EE %), and thermal analysis using differential scanning calorimeter (DSC). Preliminary microbiological studies were done using gram positive and negative bacteria. In vitro release study was performed using biorelevant media, while in vivo release study was performed in white albino rats. The yield of solid lipid microparticles (SLM) ranged from 84.2 – 98.0 %. The SLM were spherical with size ranges of 3.8 ± 1.2 to 42.0 ± 1.4 µm. The EE % calculated ranged from 83.6 – 94.8 %. Thermal analysis showed that SLM was less crystalline with high potential for drug entrapment. Microbial studies showed that cefepime retained its broad spectrum anti-bacterial activity. In vitro release showed sustained release of cefepime from SLM, and in vivo release study showed high concentration of cefepime released in the plasma of study rats. The study showed that smart engineering of solidified micellar carrier system could be used to improve oral delivery of cefepime.

Development and characterization of solid lipid microparticles loaded with ascorbic acid and produced by spray congealing

2015 ◽  
Vol 67 ◽  
pp. 52-59 ◽  
Author(s):  
Fernando Eustáquio Matos-Jr ◽  
Marcello Di Sabatino ◽  
Nadia Passerini ◽  
Carmen Sílvia Favaro-Trindade ◽  
Beatrice Albertini
Keyword(s):  
Ascorbic Acid ◽  
Solid Lipid ◽  
Solid Lipid Microparticles ◽  
Lipid Microparticles

Solid lipid microparticles loaded with cinnamon oleoresin: Characterization, stability and antimicrobial activity

2018 ◽  
Vol 113 ◽  
pp. 351-361 ◽  
Author(s):  
Fernanda Ramalho Procopio ◽  
Vivian Boesso Oriani ◽  
Bruno Nicolau Paulino ◽  
Leonardo do Prado-Silva ◽  
Glaucia Maria Pastore ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Solid Lipid ◽  
Solid Lipid Microparticles ◽  
Lipid Microparticles

scholarly journals Formulation And Evaluation Of Acyclovir Sodium Solid Lipid Microparticles

2016 ◽  
Vol 04 (05) ◽  
Author(s):  
Anantha Naik Nagappa ◽  
Gaurav Agarwal ◽  
Vinuth Chikkamath ◽  
Shilpi Agarwal ◽  
Rekha Rani ◽  
...  
Keyword(s):  
Solid Lipid ◽  
Solid Lipid Microparticles ◽  
Lipid Microparticles

scholarly journals Lidocaine-Loaded Solid Lipid Microparticles (SLMPs) Produced from Gas-Saturated Solutions for Wound Applications

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 870 ◽  
Author(s):  
Clara López-Iglesias ◽  
Cristina Quílez ◽  
Joana Barros ◽  
Diego Velasco ◽  
Carmen Alvarez-Lorenzo ◽  
...  
Keyword(s):  
Skin Barrier ◽  
Wound Dressings ◽  
Wound Complications ◽  
In Vitro Test ◽  
Skin Substitutes ◽  
Solid Lipid ◽  
Solid Lipid Microparticles ◽  
Lipid Microparticles ◽  
Saturated Solutions

The delivery of bioactive agents using active wound dressings for the management of pain and infections offers improved performances in the treatment of wound complications. In this work, solid lipid microparticles (SLMPs) loaded with lidocaine hydrochloride (LID) were processed and the formulation was evaluated regarding its ability to deliver the drug at the wound site and through the skin barrier. The SLMPs of glyceryl monostearate (GMS) were prepared with different LID contents (0, 1, 2, 4, and 10 wt.%) using the solvent-free and one-step PGSS (Particles from Gas-Saturated Solutions) technique. PGSS exploits the use of supercritical CO2 (scCO2) as a plasticizer for lipids and as pressurizing agent for the atomization of particles. The SLMPs were characterized in terms of shape, size, and morphology (SEM), physicochemical properties (ATR-IR, XRD), and drug content and release behavior. An in vitro test for the evaluation of the influence of the wound environment on the LID release rate from SLMPs was studied using different bioengineered human skin substitutes obtained by 3D-bioprinting. Finally, the antimicrobial activity of the SLMPs was evaluated against three relevant bacteria in wound infections (Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa). SLMPs processed with 10 wt.% of LID showed a remarkable performance to provide effective doses for pain relief and preventive infection effects.

Anti-Inflammatory and Gastroprotective Properties of Aspirin - Entrapped Solid Lipid Microparticles

2020 ◽  
Vol 14 (1) ◽  
pp. 78-88
Author(s):  
Salome A. Chime ◽  
Paul A. Akpa ◽  
Cosmas C. Ugwuanyi ◽  
Anthony A. Attama
Keyword(s):  
Particle Size ◽  
Drug Release ◽  
Particle Size Range ◽  
Simulated Intestinal Fluid ◽  
Solid Lipid ◽  
Solid Lipid Microparticles ◽  
Lipid Microparticles ◽  
Anti Inflammatory ◽  
Gastric Irritation

Background: Aspirin is a nonsteroidal anti-inflammatory drug that is very effective in the treatment of inflammation and other health conditions, however, it causes gastric irritation. Recently, researchers have developed patents (US9757529, 2019) of inhalable aspirin for rapid absorption and circumvention of gastric irritation. Objective: The aim of this work was to formulate aspirin-loaded lipid based formulation in order to enhance oral bioavailability and inhibit gastric irritation. Methods: This solid lipid microparticles loaded with aspirin (SLM) was formulated by a modified cold homogenization-solvent evaporation method. In vitro studies such as in vitro drug release, particle size, Encapsulation Efficiency (EE), micromeritic properties and loading capacity were carried out. Pharmacodynamics studies such as anti-inflammatory and ulcerative properties of the SLM were also carried out in Wistar rats. Results: The results showed that aspirin entrapped SLM exhibited the highest EE of 72% and particle size range of 7.60 + 0.141µm to 20.25 + 0.070µm. Formulations had about 55% drug release at 6h in simulated intestinal fluid pH 6.8. The formulations had good flowability that could facilitate filling into hard gelatin capsule shells. The SLM exhibited 100% gastroprotection against aspirin-induced ulcers (p < 0.05). The percentage of anti-inflammatory activities also showed that aspirin-entrapped SLM had 78% oedema inhibition at 7h, while the reference had 68% inhibition at 7h. Conclusion: Aspirin-entrapped SLM showed good sustained-release properties, enhanced antiinflammatory properties and total gastric protection from aspirin-induced ulcers and could be used as once-daily oral aspirin.

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