Triple Negative Breast Cancer: Experience from a North Indian Tertiary Care Center

Abstract Background The prediction of survival using the neutrophil-to-lymphocytes ratio (NLR) in metastatic breast cancer is still under debate. We aimed to determine the mortality prognostic value of the NLR in female patients with metastatic triple-negative breast cancer. Methods. We reviewed 118 medical records of patients diagnosed and treated in a tertiary-care center over a 14-year period. The cut-off value for the NLR (<2.5 and ≥2.5) was determined with receiver operating characteristic curves (area under the curve: 0.73; 95% CI: 0.615, 0.851). Survival curves were estimated using the Kaplan-Meier method and compared with the Log-rank test. Multivariate Cox regression was used to identify the risk of mortality at two years. We further performed sensitivity analyses with different cut-off values and subgroup analysis in patients that only received chemotherapy. Results. The median follow-up was 24 months. Patients with an NLR ≥2.5 had a worse overall survival compared to patients with a NLR <2.5 (6% vs. 28%, p<0.001) at two years. This outcome remained consistent when we stratified for patients that received chemotherapy (8% vs. 36%, p=0.001). Multivariate analysis identified the NLR (≥2.5 vs. <2.5) at diagnosis as a prognostic risk factor for mortality in the entire population (HR: 2.12, 95% CI: 1.32-3.39) and in patients that received chemotherapy (HR: 2.68, 95% CI: 1.46 – 4.92). Conclusions. The NLR is an accessible biomarker that predicts early mortality in patients with metastatic triple-negative breast cancer. Physicians can use these results to predict survival in these patients.

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Metachronous second primary malignancies in known breast cancer patients on 18F-fluoro-2-deoxyglucose positron emission tomography–computerized tomography in a tertiary care Center

Indian Journal of Nuclear Medicine ◽

10.4103/ijnm.ijnm_78_19 ◽

2019 ◽

Vol 34 (4) ◽

pp. 284

Author(s):

Tekchand Kalawat ◽

RanadheerGupta Manthri ◽

SaiMoulika Jeepalem ◽

VS Krishna Mohan ◽

D Bhargavi ◽

...

Keyword(s):

Breast Cancer ◽

Positron Emission Tomography ◽

Care Center ◽

Tertiary Care ◽

Emission Tomography ◽

Second Primary ◽

Tertiary Care Center ◽

Breast Cancer Patients ◽

Positron Emission ◽

Second Primary Malignancies

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Assessment of aromatase inhibitor-induced bone loss and appropriateness of supportive therapy in postmenopausal breast cancer patients at a tertiary care center

Journal of Pharmacology and Pharmacotherapeutics ◽

10.4103/jpp.jpp_61_19 ◽

2019 ◽

Vol 10 (4) ◽

pp. 118

Author(s):

Emmanuel James ◽

Rashmi Kumari ◽

WesleyM Jose

Keyword(s):

Breast Cancer ◽

Bone Loss ◽

Aromatase Inhibitor ◽

Cancer Patients ◽

Care Center ◽

Tertiary Care ◽

Supportive Therapy ◽

Postmenopausal Breast Cancer ◽

Tertiary Care Center ◽

Breast Cancer Patients

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Profile and Outcome of Triple Negative Breast Cancer at a Tertiary Care University Hospital in Nepal

Asian Pacific Journal of Cancer Care ◽

10.31557/apjcc.2020.5.2.101-105 ◽

2020 ◽

Vol 5 (2) ◽

pp. 101-105

Author(s):

Suman Khanal ◽

Yogendra P. Singh ◽

Gita Sayami ◽

Akihiko Ozaki

Keyword(s):

Breast Cancer ◽

Triple Negative Breast Cancer ◽

Triple Negative ◽

Ductal Carcinoma ◽

Tertiary Care ◽

Tumor Biology ◽

Clinical Profile ◽

University Teaching ◽

University Hospital ◽

P Value

Background: TNBC (Triple negative breast cancer) subtype (ER-/PR-/HER2-) of breast cancers are known for aggressive tumor biology and poor survival prospects, with high early relapse rate. However, little is known about the prevalence and characteristics of TNBC breast cancer in Nepal. Objectives: To clarify the geographical distribution, clinical profile and outcome of TNBC patients when compared with non-TNBC patients managed in tertiary care university hospital in Nepal. Materials and Methods: This is a study on prospective observational analyses of TNBC and non-TNBC patients managed at Tribhuvan University Teaching Hospital, Kathmandu from October 2015-March 2018. We collected and analyzed data on clinical profile, pathological tumor features and outcome of the two patient groups. Results: A total of 108 breast cancer patients were included in our study, 38 (35.2%) of which were TNBCs. Mean age at diagnosis was 49±12 years. Majority of TNBCs (29%) were concentrated in Terai districts compared to non-TNBCs (18.6%). Among TNBCs, 15.2% had tumor size 5 cm or more while only 11.9% had such finding in non-TNBCs. Majority of TNBCs and non-TNBCs were of invasive ductal carcinoma of NST histology (76.3 vs 90%). TNBC tumors were significantly of grade 3 (P value=0.003). Perineural invasion was seen more (15.8%) in TNBCs compared to 8.96% in non-TNBCs. On average, 23.6% of total nodes retrieved from axilla were positive for tumor in TNBCs compared to 21% in non-TNBCs. Three patients developed metastases in TNBCs of which two were to brain while 5 had metastases in non-TNBC with none to brain. Higher percentage of patients died in TNBC group (13.2 vs 7.1%). Conclusions: TNBCs are quite common, higher grade tumors with brain metastasis without particular geographic distribution.

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Histopathological spectrum of Cervical Lesion”– two and half Year prospective Study in Tertiary Care Center of Chhattisgarh, India

Tropical Journal of Pathology and Microbiology ◽

10.17511/jopm.2021.i02.01 ◽

2021 ◽

Vol 7 (2) ◽

pp. 65-70

Author(s):

Dr. Pratima Kujur ◽

◽

Dr. Chandrashekhar Indoria ◽

Dr. S. Bagde ◽

Dr. A. Tiwari ◽

...

Keyword(s):

Breast Cancer ◽

Relative Frequency ◽

Care Center ◽

Tertiary Care ◽

Age Distribution ◽

Tertiary Care Center ◽

Cervical Lesions ◽

Indian Women ◽

Common Cancer ◽

Neoplastic Lesion

Introduction: Cervical lesions are the leading cause of morbidity in Indian women and cervicalcancer is the second most common cancer in women worldwide next to breast cancer. Objectives:To study the age distribution, the relative frequency of various cervical lesions and histopathologicalfeatures of cervical lesions. Materials and Methods: This is a two & half years retrospective studyof all cervical biopsies and hysterectomy specimens received from September 2017 to March 2020 inthe department of pathology. Result: In a total of 485 cases studied 359 (74.1%) cases were non-neoplastic, 107(22%) were preinvasive and 19 (3.9%) cases were malignant. Cervicitis was themost common non-neoplastic lesion and squamous cell carcinoma was the most common cancer.Conclusion: Our study highlights a vast spectrum of cervical lesions and therefore early detectionand management of certain lesions can help in reducing morbidity.

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