scholarly journals Exposure of neonatal rats to maternal cafeteria feeding during suckling alters hepatic gene expression and DNA methylation in the insulin signalling pathway

2013 ◽  
Vol 9 (1) ◽  
Author(s):  
Zoe C. Daniel ◽  
Asli Akyol ◽  
Sarah McMullen ◽  
Simon C. Langley-Evans
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Insulin Signalling ◽  
Signalling Pathway ◽  
Hepatic Gene Expression ◽  
Neonatal Rats ◽  
Insulin Signalling Pathway

scholarly journals The insulin signalling pathway

2002 ◽  
Vol 12 (7) ◽  
pp. R236-R238 ◽  
Author(s):  
Jose M. Lizcano ◽  
Dario R. Alessi
Keyword(s):  
Insulin Signalling ◽  
Signalling Pathway ◽  
Insulin Signalling Pathway

Effect of food restriction on the insulin signalling pathway in rat skeletal muscle and adipose tissue

2005 ◽  
Vol 16 (10) ◽  
pp. 602-609 ◽  
Author(s):  
Ana Alonso ◽  
Yolanda Fernández ◽  
Rebeca Fernández ◽  
Patricia Ordóñez ◽  
María Moreno ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Food Restriction ◽  
Insulin Signalling ◽  
Signalling Pathway ◽  
Rat Skeletal Muscle ◽  
Insulin Signalling Pathway ◽  
Effect Of Food

Modulation of hepatic gene expression and DNA methylation in furan treated Sprague–Dawley rats

2009 ◽  
Vol 189 ◽  
pp. S137 ◽  
Author(s):  
Tao Chen ◽  
Kevin Hickling ◽  
Carolin Hamberger ◽  
Angela Mally ◽  
Kevin Chipman
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Hepatic Gene Expression ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Mulberry leaf reduces inflammation and insulin resistance in type 2 diabetic mice by TLRs and insulin Signalling pathway

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Simin Tian ◽  
Min Wang ◽  
Chenyue Liu ◽  
Hongbin Zhao ◽  
Baosheng Zhao
Keyword(s):  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Insulin Signalling ◽  
Signalling Pathway ◽  
Inflammatory Factor ◽  
Diabetic Mice ◽  
Mulberry Leaf ◽  
Insulin Signalling Pathway ◽  
Tnf Α ◽  
Necrosis Factor

Abstract Background It has been testified that Diabetes mellitus (DM) has a close association with chronic inflammation and Toll-like Receptors (TLRs), and DM could be prevented by mulberry leaf. Therefore, a hypothesis came into being that mulberry leaf could ameliorate proinflammation and insulin resistance (IR) through TLRs and insulin signalling pathways. Methods Water extracts of mulberry leaf (WEM) was given to diabetic mice by gavage for 10 weeks, and the diabetic mice was injected with low-dose streptozocin, fed with high-fat and high-sugar diet. Oral glucose tolerance tests (OGTTs) were conducted. At the same time, homeostasis model assessment of insulin (HOMA-IR) and the level of the inflammatory factor, tumour necrosis factor-α (TNF-α) was measured. The expressions of critical nodes of TLRs and insulin signalling pathway were also examined. Results WEM contributed to a significant decrease in fasting blood glucose, AUC from the investigation of OGTTs and HOMA-IR. The levels of the inflammatory factor, tumour necrosis factor-α (TNF-α) also declined. Moreover, WEM suppressed the expression of TLR2, myeloid differentiation primary-response protein 88 (MyD88), tumour-necrosis-factor receptor-associated factor 6 (TRAF6), nuclear factor kappa B (NF-κB) in the skeletal muscle. WEM could up-regulate the expression of insulin receptor (InsR) and insulin receptor substrate 1 (IRS1), and down-regulate the phosphorylation of IRS1 in adipose tissue. Conclusion Through this study, a conclusion could be made that WEM mitigates hyperglycemia, IR, and inflammation through the interactions among TLR2 signalling pathway, insulin signalling pathway and TNF-α.

scholarly journals S-resistin, a non secretable resistin isoform, impairs the insulin signalling pathway in 3T3-L1 adipocytes

2015 ◽  
Vol 71 (3) ◽  
pp. 381-390 ◽  
Author(s):  
María Rodríguez ◽  
Eduardo Moltó ◽  
Lidia Aguado ◽  
Nilda Gallardo ◽  
Antonio Andrés ◽  
...  
Keyword(s):  
Insulin Signalling ◽  
Signalling Pathway ◽  
Insulin Signalling Pathway

High Intensity Interval Training Changes Skeletal Muscle Insulin Signalling Pathway Of Obese Individuals

2017 ◽  
Vol 49 (5S) ◽  
pp. 327
Author(s):  
FLAVIO C. MAGALHAES ◽  
DENIA V. VIEIRA ◽  
MARIANA A. MATOS ◽  
KAIO C. PINHAL ◽  
KURT ESCOBAR ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
High Intensity ◽  
Insulin Signalling ◽  
Interval Training ◽  
Signalling Pathway ◽  
High Intensity Interval Training ◽  
Insulin Signalling Pathway ◽  
High Intensity Interval
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