Possible translocation of periodontal pathogens into the lymph nodes draining the oral cavity

2012 ◽  
Vol 50 (5) ◽  
pp. 827-836 ◽  
Author(s):  
G. Amodini Rajakaruna ◽  
Makoto Umeda ◽  
Keisuke Uchida ◽  
Asuka Furukawa ◽  
Bae Yuan ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Lymph Nodes ◽  
Periodontal Pathogens

scholarly journals Ossifying fibrous epulis as an IgG4-related disease of the oral cavity: a case report and literature review

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Yoshiko Ike ◽  
Takahiro Shimizu ◽  
Masaru Ogawa ◽  
Takahiro Yamaguchi ◽  
Keisuke Suzuki ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Lymph Nodes ◽  
Plasma Cells ◽  
Maxillofacial Surgery ◽  
The Body ◽  
Pathological Diagnosis ◽  
Cervical Lymph Nodes ◽  
Related Disease ◽  
Igg4 Related Disease ◽  
Organ Manifestations

Abstract Background Fibrous sclerosing tumours and hypertrophic lesions in IgG4-related disease (IgG4-RD) are formed in various organs throughout the body, but disease in the oral region is not included among individual organ manifestations. We report a case of ossifying fibrous epulis that developed from the gingiva, as an instance of IgG4-RD. Case presentation A 60-year-old Japanese man visited the Department of Oral and Maxillofacial Surgery, Gunma University Hospital, with a chief complaint of swelling of the left mandibular gingiva. A 65 mm × 45 mm pedunculated tumour was observed. The bilateral submandibular lymph nodes were enlarged. The intraoperative pathological diagnosis of the enlarged cervical lymph nodes was inflammation. Based on this diagnosis, surgical excision was limited to the intraoral tumour, which was subsequently pathologically diagnosed as ossifying fibrous epulis. Histopathologically, the ossifying fibrous epulis exhibited increased levels of fibroblasts and collagen fibres, as well as infiltration by numerous plasma cells. The IgG4/IgG cell ratio was > 40%. Serologic analysis revealed hyper-IgG4-emia (> 135 mg/dL). The patient met the comprehensive clinical diagnosis criteria and the American College of Rheumatology and European League Against Rheumatism classification criteria for IgG4-RD. Based on these criteria, we diagnosed the ossifying fibrous epulis in our patient as an IgG4-related disease. A pathological diagnosis of IgG4-related lymphadenopathy was established for the cervical lymph nodes. Concomitant clinical findings were consistent with type II IgG4-related lymphadenopathy. Conclusions A routine serological test may be needed in cases with marked fibrous changes (such as epulis) in the oral cavity and plasma cells, accompanied by tumour formation, to determine the possibility of individual-organ manifestations of IgG4-related disease.

Metastases to Supramandibular Facial Lymph Nodes in Patients With Squamous Cell Carcinoma of the Oral Cavity

2009 ◽  
Vol 67 (7) ◽  
pp. 1401-1408 ◽  
Author(s):  
Vassilis Petsinis ◽  
Nikolaos Papadogeorgakis ◽  
Ioulia Evangelou ◽  
Lampros Goutzanis ◽  
Ekaterini Pandelidaki ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell

A case of AIDS-associated Kaposi’s sarcoma occurring in the oral cavity and systemic lymph nodes

2021 ◽  
Author(s):  
Koki Nagano ◽  
Tomohiro Yamada ◽  
Kotaro Ishii ◽  
Takahiro Fujinaga ◽  
Minami Shibuya ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Lymph Nodes ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma

Submandibular Gland Invasion by Oral Cavity Cancers: A Systematic Review

2019 ◽  
Vol 161 (2) ◽  
pp. 227-234 ◽  
Author(s):  
Yusuf Dundar ◽  
Quinton Mandle ◽  
Syed N. Raza ◽  
Ho-Sheng Lin ◽  
John Cramer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Oral Cavity ◽  
Lymph Nodes ◽  
Submandibular Gland ◽  
Primary Treatment ◽  
Treatment Modalities ◽  
Adjuvant Radiation ◽  
Primary Tumors ◽  
Tumor Involvement ◽  
Oral Cavity Cancers

ObjectiveThe submandibular gland (SMG) is typically included in level I neck dissection specimens despite limited data demonstrating SMG invasion. The main objective of this article is to determine the rate and pathways of SMG invasion by squamous cell carcinoma of the oral cavity and oropharynx.Data SourcesA systematic review of relevant studies was performed, evaluating articles identified via the PubMed, Cochrane, and Medline databases.Review MethodsDescriptive features of primary tumors, primary treatment modalities, the rate and pathway of SMG invasion, and survival outcomes, if present, were reported following the PRISMA guidelines.ResultsThe initial literature search yielded 273 articles, of which 17 met inclusion criteria. A total of 2306 patients with 2792 SMG resections were analyzed. Fifty-eight resections (2.0%) were revealed to have tumor involvement. Among patients with SMG tumor involvement, the most common invasion pathway was direct SMG invasion by primary tumor (43 of 58, 74.1%). The second-most common mode of SMG invasion was from involved adjacent lymph nodes (10 of 58, 17.2%). Only 3 SMG resections out of 2792 (0.1%) had isolated metastatic parenchyma without evidence of direct tumor invasion or invasion by involved lymph nodes.ConclusionGiven this rarity of SMG involvement, preservation of SMG might be feasible in selected patient population. However, additional studies need to examine the functionality of preserved SMGs among patients who receive postoperative adjuvant radiation therapy.

scholarly journals Frequency of metastasis to posterior triangle and lower deep jugular lymph nodes in patients with squamous cell carcinoma of oral cavity having clinically N1 neck

2019 ◽  
Vol 5 (5) ◽  
pp. 1286
Author(s):  
Shilpa Varchasvi ◽  
Azeem Moyihuddin
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Oral Cavity ◽  
Lymph Nodes ◽  
Prospective Study ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Buccal Mucosa ◽  
Research Centre ◽  
Posterior Triangle

<p class="abstract"><strong>Background:</strong> Oral cancer is the sixth most common cancer in the world and is largely preventable. The objective of the study is to find out the frequency of metastasis to posterior triangle lymph nodes and lower deep jugular (supraclavicular) lymph nodes in patients with squamous cell carcinoma of oral cavity having clinically N<sub>1 </sub>neck.</p><p class="abstract"><strong>Methods:</strong> A hospital based prospective study.<strong> </strong>This prospective study was conducted in R. L. Jalappa Hospital and Research Centre and SDU Medical College Kolar, Karnataka. 30 patients having oral squamous cell carcinoma with clinically N<sub>1 </sub>neck (single ipsilateral lymph node less than 3cms in diameter) undergoing modified radical neck dissection in R. L. Jalappa Hospital and Research Centre.  </p><p class="abstract"><strong>Results:</strong> In our study, 4 were male (13%) and 26 were females (87%). The age of the patients ranged from 41-70 years with a mean age of 53 years.<strong> </strong>Majority of primary tumours were buccal mucosa tumours (24). We had 6 anterior 2/3<sup>rd</sup> tongue tumours. The primary tumour staging included 17 T<sub>2 </sub>lesions (57%), 3 T<sub>3 </sub>lesions (10%), 10 T<sub>4 </sub>lesions (33%) in patients with buccal mucosa carcinoma, fourteen patients had T<sub>2 </sub>disease, 9 patients had T<sub>4</sub> and one patient had T<sub>3</sub> disease.</p><p class="abstract"><strong>Conclusions:</strong> Most common nodal involvement in buccal mucosa carcinoma was level Ib (submandibular lymph node). The incidence of level IV (supraclavicular) and level V (posterior triangle) lymph node metastasis is low in buccal mucosa carcinoma patients with clinically N<sub>1</sub> neck.</p>

scholarly journals Oral Microbiome of Tobacco Smokers: A Shift in Composition

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 57s-57s ◽  
Author(s):  
O. Ogba ◽  
J. Ewa ◽  
O. Olorode
Keyword(s):  
Oral Cancer ◽  
Oral Cavity ◽  
Tobacco Smoking ◽  
Lung Diseases ◽  
Color Change ◽  
Bacterial Colonization ◽  
Oral Microbiome ◽  
Periodontal Pathogens ◽  
Microbiological Techniques ◽  
Minimum Age

Background: The use of tobacco may affect the human oral microbiome resulting in numerous diseases including cancer. There are more than 1.3 billion tobacco smokers worldwide with 4.5 million adult Nigerians addressed as tobacco addicts. Tobacco smoking causes oral cancer, color change on the teeth, halitosis, periodontitis and other health implications. Aim: The study was aimed at determining the changes caused by tobacco smoking on the oral microbiome of cigarette smokers and the shift toward organisms that may cause oral cancer and lung diseases. Methods: One hundred and twenty subjects made of 60 tobacco smokers and 60 nonsmokers were enrolled for the study. Oral swabs were collected from the oral cavity of the subjects using sterile swab sticks under standard aseptic methods. The specimens were subjected to microscopy and culture. Organisms were identified using standard microbiological techniques. Results: The mean age of the subjects was 26.9 ± 3.4 years, with minimum age 18.0 years. There was a higher rate of bacterial colonization 86.7% among smokers than nonsmokers (χ2 = 299.0, P = 0.0002). Most members of the oral biofilm belonged to the Enterobacteriaceae with Klebsiella pneumoniae being the most prevalent isolate among smokers while Pseudomonas aeruginosa 4 (20.0%) were the most prevalent bacterial isolates among the control subjects. Tooth decay 19 (36.5%) was the oral cavity disorder among smokers associated with the highest number of isolates, followed by halitosis 18 (34.6%) and mouth ulcer 7 (13.4%). Halitosis was mostly associated with Candida species 5 (71.4%). There was a statistically significant association between oral cavity conditions and microbial isolates among smokers (χ2 = 299.0, P = 0.002). Conclusion: Smoking may have altered bacterial acquisition and oral mucosal colonization in favor of periodontal pathogens. This study have shown that smoking predisposes to oral cavity diseases which may predispose to oral cancer or lung diseases. The campaign against smoking should therefore be intensified as this may help to improve the oral health of smokers.

scholarly journals Peripheral T-Cell Lymphoma in the Oral Cavity of a Cow

2019 ◽  
Vol 47 ◽  
Author(s):  
Carolina De Castro Guizelini ◽  
Rayane Chitolina Pupin ◽  
Claudio Severo Lombardo de Barros ◽  
Saulo Petinatti Pavarini ◽  
Danilo Carloto Gomes
Keyword(s):  
T Cell ◽  
Oral Cavity ◽  
Lymph Nodes ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Anatomic Site ◽  
Neoplastic Cells ◽  
Enzootic Bovine Leukosis ◽  
Internal Iliac ◽  
Bovine Leukosis

Background: Squamous cell carcinomas and lymphomas are the most prevalent neoplasms in cattle, the latter usually being attributed to infection by bovine leukemia virus (BLV). Neoplasms of the oral cavity are sporadic in cattle, with but a single case of lymphoma involving this anatomic site in a bovine reported to date. This paper reports a case of lymphoma involving the oral cavity of a dairy cow. The clinical and pathological aspects of the tumor are described and discussed.Case: A 39-month-old Holstein-Friesian cow was presented with weight loss and a tumorous growth in the left masseter region, tearing in the left eye, and mild ipsilateral exophthalmos. Treatment with antibiotics was unsuccessful. The tumor growth was 16 x 11 cm, with a soft center and firm periphery, multilobulated, with white intercalated with black and friable areas from which a fetid odor emanated. The cut surface was predominantly white-yellow. A cross-section of the head, caudal to the second molar, revealed a mass infiltrating and almost completely obliterating the left nasal cavity, destroying the frontal sinus, the ventral conchae, and the middle and ventral meatus, and compressing the common meatus. The tracheobronchial, mediastinal, and internal iliac lymph nodes were enlarged and masses with similar characteristics to those in the oral cavity replace their parenchyma. Microscopically, the mass consisted of large neoplastic lymphocytes arranged in a non-encapsulated and infiltrative mantle and supported by scarce fibrovascular tissue. The cytoplasm of neoplastic cells was scarce and had distinct boundaries; the nuclei were round or oval, the chromatin was finely granulated, and the prominent nucleolus had occasionally multiplied. Nuclear pleomorphism was marked and there were, on average, five mitotic figures per microscopic field of 400x. Similar neoplastic cells obliterated the normal structure of the tracheobronchial, mediastinal, and internal iliac lymph nodes. In the immunohistochemical examination, labeling was diffuse and moderate in the cytoplasm of neoplastic cells when a CD3 antibody was used, and negative when antibodies to CD79α, cytokeratin, and vimentin were used. Due to its characteristic markings in the immunohistochemistry panel, the neoplasm was classified as an unspecified peripheral T-cell lymphoma.Discussion: The diagnosis of lymphoma was based on clinical signs and gross and histopathological findings, and was confirmed by immunohistochemistry. Lymphomas in cattle are common in several organs as part of enzootic bovine leukosis, a virus-induced type of B-cell lymphoma. However, lymphomas are rare in the oral cavity. The clinical presentation observed in this case points to the upper alimentary tract as the primary site of the neoplasm once clinical respiratory signs were not observed in the cow. The neoplasm cells described here presented a T-cell profile in immunohistochemistry panel, suggesting that the tumor should be included in the sporadic form of bovine leukosis since B-cells are the cellular population in cases of enzootic bovine leukosis. However, since the diagnosis of enzootic leukosis was not definitively excluded in this case, the cause of the neoplasia cannot be conclusively determined. It is concluded that, although rare, lymphomas may indeed occur in the bovine oral cavity and should be included in the differentials list for tumoral growth in the lateral region of the bovine face.

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