A Cross Sectional Study on T Cells and Subsets in Chronic Lymphocytic Leukemia and their Association with Clinical Phenotype

2021 ◽  
Author(s):  
Mili Jain ◽  
Anushree Rai ◽  
Rashmi Kushwaha ◽  
Geeta Yadav ◽  
Sanjay Mishra ◽  
...  
Keyword(s):  
T Cells ◽  
Chronic Lymphocytic Leukemia ◽  
Clinical Phenotype ◽  
Cross Sectional Study ◽  
Lymphocytic Leukemia ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals ZAP-70 expression is associated with increased CD4 central memory T cells in chronic lymphocytic leukemia: cross-sectional study

2018 ◽  
Vol 40 (4) ◽  
pp. 317-325 ◽  
Author(s):  
Rodolfo Patussi Correia ◽  
Flávia Amoroso Matos e Silva ◽  
Nydia Strachman Bacal ◽  
Paulo Vidal Campregher ◽  
Nelson Hamerschlak ◽  
...  
Keyword(s):  
T Cells ◽  
Chronic Lymphocytic Leukemia ◽  
Memory T Cells ◽  
Cross Sectional Study ◽  
Central Memory ◽  
Lymphocytic Leukemia ◽  
Sectional Study ◽  
Cross Sectional ◽  
Central Memory T Cells

scholarly journals Cognitive function in patients with chronic lymphocytic leukemia: a cross-sectional study examining effects of disease and treatment

2020 ◽  
Vol 61 (7) ◽  
pp. 1627-1635
Author(s):  
AnnaLynn M. Williams ◽  
Edwin van Wijngaarden ◽  
Christopher L. Seplaki ◽  
Charles E. Heckler ◽  
Miriam T. Weber ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Chronic Lymphocytic Leukemia ◽  
Cross Sectional Study ◽  
Lymphocytic Leukemia ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Clinical Staging and Flowcytomteric CD38 and Zap 70 Prognostic Indicators in Sudanese Patients with Chronic Lymphocytic Leukemia

2020 ◽  
Author(s):  
Enaam Abdelrhman Abdelgader ◽  
Nada Hassan Eltayeb ◽  
Tasniem Ahmed Eltahir ◽  
Osama Ali Altayeb ◽  
Eman Abbass Fadul ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Stage Iv ◽  
Cross Sectional Study ◽  
Lymphocytic Leukemia ◽  
Clinical Staging ◽  
Prognostic Indicators ◽  
P Value ◽  
Cross Sectional ◽  
Cd38 Expression ◽  
Staging Systems

Background: The clinical course of chronic lymphocytic leukemia is highly variable. The determination of ZAP70 and CD38 is increasingly utilized as prognostic factor for chronic lymphocytic leukemia. The aim of conducting this study was to investigate the frequency of CD38 and ZAP70 expression among Sudanese Chronic lymphocytic leukemia (CLL) patients and to relate them to the Binet and Rai clinical staging systems. Method: A total of 93 patients (mean age; 62.29 ± 11.68, sd) were enrolled in this cross-sectional study. CD38 and ZAP70 expression levels were measured with four color flowcytometry using the cut-off values of 20% for ZAP70 and 30% for CD38 expression. Staging was assessed by using clinical examination and CBC for all patients. Data were analyzed using the Statistical Package for Social science for Windows (SPSS), version 22. Results: There were 93 CLL patients and the median age of the group was 63 years (36–95 years). About 71% of the patients presented with lymphadenopathy, 53.8% with splenomegaly, 73.1% with anemia, and 45.2% with thrombocytopenia. There was higher frequency of Binet stage C and Rai stage IV (62 [66.6%] patients and 34 [36.5%] patients, respectively). In addition, CD38 and ZAP70 showed higher frequency among Binet and Rai advance stages. ZAP70 and CD38 positivity were detected in 21 patients (22.6%) and 31 patients (33.3%), respectively. There was no statistically significant association between ZAP70 and CD38 and clinical staging systems (P-value > 0.05). Conclusion: No significant association was observed between Flowcytometric (CD38 and Zap70) Prognostic Indicators and clinical staging systems. Keywords: chronic lymphocytic Leukemia, Flowcytometry, ZAP70, CD38, clinical staging systems

scholarly journals Trauma-Induced Long-Term Alterations of Human T Cells and Monocytes—Results of an Explorative, Cross-Sectional Study

Shock ◽  
2020 ◽  
Vol 53 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Sophie Ruhrmann ◽  
Emmanuel Schneck ◽  
Melanie Markmann ◽  
Jan Zink ◽  
Thomas Simon Zajonz ◽  
...  
Keyword(s):  
T Cells ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Human T Cells

scholarly journals Comparison between LDH with Zap-70 and CD38 as prognostic Markers in Chronic Lymphocytic Leukemia Sudanese patients - A Pilot Study in Khartoum State

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Yassmin Hassan Mohammed ◽  
Salma Hussein Elhassan ◽  
Mariam Abbas Ibrahim ◽  
May Mohammed Ali ◽  
Nuha Eljaili Abubaker ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Prognostic Markers ◽  
Computer Software ◽  
Cross Sectional Study ◽  
Lymphocytic Leukemia ◽  
Poor Correlation ◽  
P Value ◽  
Cross Sectional ◽  
Dehydrogenase Enzyme ◽  
Program Version

Background:  Several prognostic markers are used in clinical stages of Chronic Lymphocytic Leukemia (CLL); including lactate dehydrogenase enzyme (LDH), CD38 and Zeta associated protein kinase (ZAP70). This study aimed to compare LDH with ZAP70 and CD38 as prognostic markers in Sudanese patients with CLL. Materials and Methods: Fifty newly diagnosed patients with CLL were enrolled in this cross-sectional study, the age of patients ranged between 36 - 85 years, with mean of 62 years. Of total patients; there were 34 males (68%) and 16 females (32%). Blood samples were obtained and LDH measurement was done by using Dirui CS-T240 automated analyzer while CD38 and ZAP-70 were measured by flowcytometry. Data were analyzed by statistical package for social science (SPSS) computer software program version 21. Results: The present study revealed a significant association between LDH and Rai staging (p. value= 0.002), when LDH compared with ZA-70 and CD38 as reference prognostic markers; poor correlation between CD38 and LDH was found (R2= 0.086, P value= 0.034) and no correlation between LDH level and ZAP-70 expression (R2= 000, P value= 0.960). In conclusion: According to the outcomes of this study; ZAP-70 and CD38 cannot be substituted by LDH as a prognostic marker.

scholarly journals Activation and maturation of peripheral blood T cells in HIV-1-infected and HIV-1-uninfected adults in Burkina Faso: a cross-sectional study

2011 ◽  
Vol 14 (1) ◽  
pp. 57 ◽  
Author(s):  
Fabrice Tiba ◽  
Frans Nauwelaers ◽  
Lassana Sangaré ◽  
Boubacar Coulibaly ◽  
Hans-Georg Kräusslich ◽  
...  
Keyword(s):  
T Cells ◽  
Burkina Faso ◽  
Peripheral Blood ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Hiv 1

Clinical characterization of delayed alcohol-induced headache

Neurology ◽  
2020 ◽  
Vol 95 (15) ◽  
pp. e2161-e2169 ◽  
Author(s):  
David García-Azorín ◽  
Laura Aparicio-Cordero ◽  
Blanca Talavera ◽  
Andrew Johnson ◽  
Henrik Winther Schytz ◽  
...  
Keyword(s):  
Alcohol Intake ◽  
Clinical Phenotype ◽  
Cross Sectional Study ◽  
Moderate Intensity ◽  
Sectional Study ◽  
Cross Sectional ◽  
Csf Pressure ◽  
Pressure Headache

ObjectiveTo evaluate the International Classification of Headache Disorders (ICHD) criteria and to characterize the clinical phenotype of delayed alcohol-induced headache (DAIH).MethodsWe conducted a cross-sectional study of university students who voluntarily consumed alcohol and experienced headache. Participants completed a survey that included demographic and clinical data. We analyzed the phenotype of the headache, validated ICHD phenotype criteria for DAIH, and analyzed whether participants fulfilled criteria for low-CSF-pressure headache or migraine.ResultsA total of 1,108 participants were included (58% female, mean age 23 years, 41% with headache history). Mean alcohol intake was 158 g; spirits were consumed by 60% of the participants; beer was consumed by 41%; and wine was consumed by 18%. The ICHD criteria for DAIH were met in 95% of the participants. Headache duration (mean, 6.7 hours) correlated with total grams of alcohol consumed (r = 0.62, p = 0.03). Pain was bilateral in 85% of patients with predominantly frontal topography (43%). Pain quality was mainly pressing (60%) or pulsatile (39%) and was aggravated by physical activity in 83% of participants. ICHD low-CSF pressure-headache criteria were fulfilled in 58% of patients, and migraine criteria were fulfilled by 36%.ConclusionsDAIH is a moderate-intensity headache, is typically bilateral, and presents with frontal predominance and a pressing quality. The phenotype of DAIH combines features of both migraine and low-CSF-pressure headaches.

Sign in / Sign up

Export Citation Format

Share Document