scholarly journals Irisin, a Novel Myokine Responsible for Exercise Induced Browning of White Adipose Tissue

2012 ◽  
Vol 28 (1) ◽  
pp. 102-103 ◽  
Author(s):  
Rajni Dawar Mahajan ◽  
Surajeet Kumar Patra
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Exercise Induced

scholarly journals Fndc5 loss‐of‐function attenuates exercise‐induced browning of white adipose tissue in mice

2019 ◽  
Vol 33 (5) ◽  
pp. 5876-5886 ◽  
Author(s):  
Yan Xiong ◽  
Zihuan Wu ◽  
Bin Zhang ◽  
Chao Wang ◽  
Fengyi Mao ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Loss Of Function ◽  
Exercise Induced

scholarly journals Diurnal Regulation Of Exercise-induced Anabolic And Catabolic Signaling In White Adipose Tissue

2020 ◽  
Vol 52 (7S) ◽  
pp. 920-920
Author(s):  
Elias Maurice Malek ◽  
Caitlin K. Reynolds ◽  
Charli D. Aguilar ◽  
Graham R. McGinnis
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Exercise Induced ◽  
Diurnal Regulation

Biochemical adaptations in white adipose tissue following aerobic exercise: from mitochondrial biogenesis to browning

2020 ◽  
Vol 477 (6) ◽  
pp. 1061-1081 ◽  
Author(s):  
Greg L. McKie ◽  
David C. Wright
Keyword(s):  
Adipose Tissue ◽  
Aerobic Exercise ◽  
White Adipose Tissue ◽  
Mitochondrial Biogenesis ◽  
Past Research ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Underlying Mechanisms ◽  
Exercise Induced ◽  
A Site

Our understanding of white adipose tissue (WAT) biochemistry has evolved over the last few decades and it is now clear that WAT is not simply a site of energy storage, but rather a pliable endocrine organ demonstrating dynamic responsiveness to the effects of aerobic exercise. Similar to its established effects in skeletal muscle, aerobic exercise induces many biochemical adaptations in WAT including mitochondrial biogenesis and browning. While past research has focused on the regulation of these biochemical processes, there has been renewed interest as of late given the potential of harnessing WAT mitochondrial biogenesis and browning to treat obesity and type II diabetes. Unfortunately, despite increasing evidence that innumerable factors, both exercise induced and pharmacological, can elicit these biochemical adaptations in WAT, the underlying mechanisms remain poorly defined. Here, we begin with a historical account of our understanding of WAT exercise biochemistry before presenting detailed evidence in favour of an up-to-date model by which aerobic exercise induces mitochondrial biogenesis and browning in WAT. Specifically, we discuss how aerobic exercise induces increases in WAT lipolysis and re-esterification and how this could be a trigger that activates the cellular energy sensor 5′ AMP-activated protein kinase to mediate the induction of mitochondrial biogenesis and browning via the transcriptional co-activator peroxisome proliferator-activated receptor gamma co-activator-1 alpha. While this review primarily focuses on mechanistic results from rodent studies special attention is given to the translation of these results, or lack thereof, to human physiology.

Sestrin2 ablation attenuates the exercise‐induced browning of white adipose tissue in C57BL/6J mice

2022 ◽  
Author(s):  
Lu Wang ◽  
Xinmeng Liu ◽  
Sujuan Liu ◽  
Yanmei Niu ◽  
Li Fu
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Exercise Induced

scholarly journals Uncoupling protein (UCP)1 and exercise induced ‘browning’ of white adipose tissue is absent at thermoneutrality

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Peter Aldiss ◽  
Jo Lewis ◽  
Fran Ebling ◽  
David Bookcock ◽  
Helen Budge ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Uncoupling Protein ◽  
Exercise Induced

scholarly journals The confounding effects of sub-thermoneutral housing temperatures on aerobic exercise-induced adaptations in mouse subcutaneous white adipose tissue

2021 ◽  
Vol 17 (6) ◽  
pp. 20210171
Author(s):  
Greg L. McKie ◽  
David C. Wright
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Model Organism ◽  
Human Biology ◽  
Thermal Biology ◽  
Adipose Tissue Metabolism ◽  
Tissue Metabolism ◽  
Subcutaneous White Adipose Tissue ◽  
Housing Temperature ◽  
Exercise Induced

Mice are the most commonly used model organism for human biology, and failure to acknowledge fundamental differences in thermal biology between these species has confounded the study of adipose tissue metabolism in mice and its translational relevance to humans. Here, using exercise biochemistry as an example, we highlight the subtle yet detrimental effects sub-thermoneutral housing temperatures can have on the study of adipose tissue metabolism in mice. We encourage academics and publishers to consider ambient housing temperature as a key determinant in the methodological conception and reporting of all research on rodent white adipose tissue metabolism.

scholarly journals The Role of Exercise, Diet, and Cytokines in Preventing Obesity and Improving Adipose Tissue

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1459
Author(s):  
Muhammed Mustafa Atakan ◽  
Şükran Nazan Koşar ◽  
Yasemin Güzel ◽  
Hiu Tung Tin ◽  
Xu Yan
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Healthy Lifestyle ◽  
Brown Adipocyte ◽  
Regular Exercise ◽  
Global Epidemic ◽  
Prevalence Of Obesity ◽  
Exercise Induced ◽  
Response To Exercise

The prevalence of obesity continues to rise worldwide despite evidence-based public health recommendations. The promise to adopt a healthy lifestyle is increasingly important for tackling this global epidemic. Calorie restriction or regular exercise or a combination of the two is accepted as an effective strategy in preventing or treating obesity. Furthermore, the benefits conferred by regular exercise to overcome obesity are attributed not only to reduced adiposity or reduced levels of circulating lipids but also to the proteins, peptides, enzymes, and metabolites that are released from contracting skeletal muscle or other organs. The secretion of these molecules called cytokines in response to exercise induces browning of white adipose tissue by increasing the expression of brown adipocyte-specific genes within the white adipose tissue, suggesting that exercise-induced cytokines may play a significant role in preventing obesity. In this review, we present research-based evidence supporting the effects of exercise and various diet interventions on preventing obesity and adipose tissue health. We also discuss the interplay between adipose tissue and the cytokines secreted from skeletal muscle and other organs that are known to affect adipose tissue and metabolism.

Sexual-Dimorphism in Exercise-Induced Beiging and Altered Mitochondrial Function in Inguinal White Adipose Tissue (iWAT) from the Mouse

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 758-P
Author(s):  
PASQUALE NIGRO ◽  
ROELAND MIDDELBEEK ◽  
CHRISTIANO R. ALVES ◽  
BRENT G. ALBERTSON ◽  
LESLIE A. ROWLAND ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Sexual Dimorphism ◽  
White Adipose Tissue ◽  
Mitochondrial Function ◽  
Exercise Induced
Sign in / Sign up

Export Citation Format

Share Document