scholarly journals Biochemical characterization of breast tumors by in vivo and in vitro magnetic resonance spectroscopy (MRS)

2009 ◽  
Vol 1 (1) ◽  
pp. 21-26 ◽  
Author(s):  
Uma Sharma ◽  
Naranamangalam R. Jagannathan
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Biochemical Characterization ◽  
Breast Tumors ◽  
Resonance Spectroscopy

scholarly journals In vivo and in vitro hepatic phosphorus-31 magnetic resonance spectroscopy and electron microscopy in chronic ductopenic rejection of human liver allografts

Gut ◽  
1998 ◽  
Vol 42 (5) ◽  
pp. 735-743 ◽  
Author(s):  
S D Taylor-Robinson ◽  
J Sargentoni ◽  
J D Bell ◽  
E L Thomas ◽  
C D Marcus ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Graft Function ◽  
Phospholipid Metabolism ◽  
Biliary Duct ◽  
Resonance Spectroscopy ◽  
Liver Transplant Recipients

Background—In vivo hepatic phosphorus-31 magnetic resonance spectroscopy (MRS) provides non-invasive information about phospholipid metabolism.Aims—To delineate MRS abnormalities in patients with chronic ductopenic rejection (CDR) and to characterise spectral changes by in vitro MRS and electron microscopy.Patients and methods—Sixteen liver transplant recipients (four with CDR; 12 with good graft function) and 29 controls (23 healthy volunteers; six patients with biliary duct strictures) were studied with in vivo 31P MRS. Peak area ratios of phosphomonoesters (PME) and phosphodiesters (PDE), relative to nucleotide triphosphates (NTP) were measured. In vitro MRS and electron microscopy were performed on biopsy specimens from five patients with CDR, freeze clamped at retransplantation. Phosphoethanolamine (PE), phosphocholine (PC), glycerophosphorylethanolamine (GPE), and glycerophosphorylcholine (GPC) concentrations were measured.Results—The 12 patients with good graft function displayed no spectral abnormalities in vivo; the four patients with CDR showed significantly elevated PME:NTP (p<0.01) and PDE:NTP ratios (p<0.005). Patients with biliary strictures had significant differences in PME:NTP (p<0.01) from patients with CDR, but not in mean PDE:NTP. In vitro spectra from CDR patients showed elevated PE and PC, mirroring the in vivo changes in PME, but reduced GPE and GPC concentrations were observed, at variance with the in vivo PDE findings. On electron microscopy, there was no proliferation in hepatocyte endoplasmic reticulum.Conclusions—The increase in PME:NTP reflects altered phospholipid metabolism in patients with CDR, while the increase in PDE:NTP may represent a significant contribution from bile phospholipid.

scholarly journals Characterization of the Testicular Cell Types Present in the Rat by in Vivo 31P Magnetic Resonance Spectroscopy

1991 ◽  
Vol 45 (1) ◽  
pp. 122-127 ◽  
Author(s):  
Jeroen Van Der Grond ◽  
Ans M. M. Van Pelt ◽  
Cees J. A. Van Echteld ◽  
Grietje Dukstra ◽  
J. Anton Grootegoed ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Cell Types ◽  
Resonance Spectroscopy ◽  
Testicular Cell ◽  
31P Magnetic Resonance Spectroscopy

In Vivo and Ex Vivo Magnetic Resonance Spectroscopy in the Characterization of Hemangioblastoma Cyst Fluid

2014 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Girolamo Crisi ◽  
Silvano Filice ◽  
Thelma A. Pertinhez ◽  
Elisa Ventura ◽  
Franco Servadei
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Ex Vivo ◽  
Cyst Fluid ◽  
Resonance Spectroscopy

Characterization of Choline Compounds with In Vitro 1H Magnetic Resonance Spectroscopy for the Discrimination of Primary Brain Tumors

1999 ◽  
Vol 34 (3) ◽  
pp. 230-235 ◽  
Author(s):  
JEAN SABATIER ◽  
VERONIQUE GILARD ◽  
MYRIAM MALET-MARTINO ◽  
JEAN-PHILIPPE RANJEVA ◽  
CORINNE TERRAL ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Brain Tumors ◽  
Resonance Spectroscopy ◽  
1H Magnetic Resonance Spectroscopy ◽  
Primary Brain Tumors

scholarly journals Characterization of Carbonic Anhydrase In Vivo Using Magnetic Resonance Spectroscopy

2020 ◽  
Vol 21 (7) ◽  
pp. 2442
Author(s):  
Jyoti Singh Tomar ◽  
Jun Shen
Keyword(s):  
Magnetic Resonance ◽  
Carbonic Anhydrase ◽  
Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Carbonic Anhydrases ◽  
Magnetization Saturation ◽  
Wide Range ◽  
In Vivo Characterization

Carbonic anhydrase is a ubiquitous metalloenzyme that catalyzes the reversible interconversion of CO2/HCO3−. Equilibrium of these species is maintained by the action of carbonic anhydrase. Recent advances in magnetic resonance spectroscopy have allowed, for the first time, in vivo characterization of carbonic anhydrase in the human brain. In this article, we review the theories and techniques of in vivo 13C magnetization (saturation) transfer magnetic resonance spectroscopy as they are applied to measuring the rate of exchange between CO2 and HCO3− catalyzed by carbonic anhydrase. Inhibitors of carbonic anhydrase have a wide range of therapeutic applications. Role of carbonic anhydrases and their inhibitors in many diseases are also reviewed to illustrate future applications of in vivo carbonic anhydrase assessment by magnetic resonance spectroscopy.

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