Caffeic Acid Phenethyl Ester (CAPE) Protects PC12 Cells from Cisplatin-Induced Neurotoxicity by Activating the NGF-Signaling Pathway

2017 ◽  
Vol 34 (1) ◽  
pp. 32-46 ◽  
Author(s):  
Rafaela Scalco Ferreira ◽  
Neife Aparecida Guinaim dos Santos ◽  
Nádia Maria Martins ◽  
Laís Silva Fernandes ◽  
Antonio Cardozo dos Santos
Keyword(s):  
Signaling Pathway ◽  
Caffeic Acid ◽  
Pc12 Cells ◽  
Caffeic Acid Phenethyl Ester ◽  
Ngf Signaling

Neuroprotective effect of NDEELNK from sea cucumber ovum against scopolamine-induced PC12 cells damage through enhancing energy metabolism and upregulation of PKA/BDNF/NGF signaling pathway

2021 ◽  
Author(s):  
Yue Zhao ◽  
Yifei Dong ◽  
Qi Ge ◽  
Pengbo Cui ◽  
Na Sun ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Signaling Pathway ◽  
Pc12 Cells ◽  
Sea Cucumber ◽  
Molecular Mechanisms ◽  
Neuroprotective Effect ◽  
Ngf Signaling ◽  
Neuroprotective Function

The aim of study was to evaluate the neuroprotective function of sea cucumber ovum peptides-derived NDEELNK and explore underlying molecular mechanisms. NDEELNK exerted neuroprotective effect by improving the acetylcholine (ACh)...

Caffeic Acid Phenethyl Ester (CAPE) Protects PC12 Cells Against Cisplatin-Induced Neurotoxicity by Activating the AMPK/SIRT1, MAPK/Erk, and PI3k/Akt Signaling Pathways

2019 ◽  
Vol 36 (1) ◽  
pp. 175-192 ◽  
Author(s):  
Rafaela Scalco Ferreira ◽  
Neife Aparecida Guinaim dos Santos ◽  
Carolina P. Bernardes ◽  
Flávia Malvestio Sisti ◽  
Lilian Amaral ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Caffeic Acid ◽  
Pc12 Cells ◽  
Caffeic Acid Phenethyl Ester ◽  
Akt Signaling

scholarly journals A synthetic snake-venom-based tripeptide (Glu-Val-Trp) protects PC12 cells from MPP + toxicity by activating the NGF-signaling pathway

Peptides ◽  
2018 ◽  
Vol 104 ◽  
pp. 24-34 ◽  
Author(s):  
Carolina P. Bernardes ◽  
Neife A.G. Santos ◽  
Flavia M. Sisti ◽  
Rafaela Scalco Ferreira ◽  
Norival A. Santos-Filho ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Pc12 Cells ◽  
Snake Venom ◽  
Ngf Signaling

scholarly journals NGF-induction of the metalloproteinase-transin/stromelysin in PC12 cells: involvement of multiple protein kinases.

1991 ◽  
Vol 114 (5) ◽  
pp. 1037-1048 ◽  
Author(s):  
C M Machida ◽  
J D Scott ◽  
G Ciment
Keyword(s):  
Signaling Pathway ◽  
Protein Kinases ◽  
Pc12 Cells ◽  
Intracellular Signaling ◽  
Kinase Inhibitors ◽  
Kinase Inhibitor ◽  
Intracellular Signaling Pathway ◽  
Multiple Protein ◽  
Serine Kinases ◽  
Ngf Signaling

In previous work, we found that nerve growth factor (NGF) induced expression of the mRNA transcript encoding the metalloproteinase transin/stromelysin in PC12 cells. Transin was found, moreover, to be a "late" gene product whose expression correlated with neurites extension. In this study, various aspects of the NGF intracellular signaling pathway in PC12 cells are investigated. We show that the protein kinase inhibitor staurosporine, but not various other kinase inhibitors, specifically blocked the NGF induction of transin. Preliminary characterization of this staurosporine-sensitive kinase suggest that it does not correspond to a tyrosine kinase, nor various serine kinases, and that it is involved both at the transcriptional and posttranscriptional levels of transin gene regulation. In contrast to these effects of staurosporine, various activators of protein kinases C and A augmented the NGF induction of transin. Similar effects of these kinase inhibitors and activators were also observed with the expression of various immediate-early genes that have been proposed to mediate the transcriptional effects of NGF, including c-fos and c-jun. These data suggest, therefore, that the NGF induction of transin mRNA expression involves multiple protein kinases acting at a number of postreceptor regulatory steps in the NGF signaling pathway.

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