The Role of PKC in Regulating NMDARs in Aluminum-Induced Learning and Memory Impairment in Rats

2021 ◽  
Author(s):  
Chanting He ◽  
Jingjing Ji ◽  
Xiaoyan Zhao ◽  
Yang Lei ◽  
Huan Li ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Memory Impairment

scholarly journals Role of Endoplasmic Reticulum Stress in Learning and Memory Impairment and Alzheimer's Disease-Like Neuropathology in the PS19 and APPSwe Mouse Models of Tauopathy and Amyloidosis

eNeuro ◽  
2017 ◽  
Vol 4 (4) ◽  
pp. ENEURO.0025-17.2017 ◽  
Author(s):  
Denise Isabelle Briggs ◽  
Erwin Defensor ◽  
Pooneh Memar Ardestani ◽  
Bitna Yi ◽  
Michelle Halpain ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Learning And Memory ◽  
Mouse Models ◽  
Memory Impairment

scholarly journals The Role of Alteration of Glutamic Acid and Gaba in Learning and Memory Impairment of Rats Induced by Aluminum

2005 ◽  
Vol 3 (2) ◽  
pp. 97-101
Author(s):  
Q. Niu ◽  
P. Niu ◽  
Q. Zhang ◽  
L. Wang ◽  
S. He ◽  
...  
Keyword(s):  
Amino Acids ◽  
Cerebral Cortex ◽  
Glutamic Acid ◽  
Learning And Memory ◽  
Memory Impairment ◽  
High Performance ◽  
Gamma Aminobutyric Acid ◽  
Aluminum Exposure ◽  
Step Down

Aluminum exposure has been reported to be related to learning and memory impairment. This study examines the role of aluminum in alterating amino acids of the cerebral cortex of rats. The Step-down type tests were performed to investigate the alteration of learning and memory of rats induced by aluminum. The amino acids in the cerebral cortex were detected by high performance liquid chromatography (HLPC). Results show that the amounts of aluminum in the cerebral cortex increased by 5.0mgAl3+/(Kg·BW) group and 10.0mg Al3+/(Kg·BW) group. In the Step-down type test, the EN1 increased significantly in the Al3+ 10.0mg/(Kg·BW) group. The latency shortened obviously and the EN2 increased significantly in the 10.0mg Al3+/(Kg·BW) group. The content of Glu (Glutamic acid) increased but the content of GABA (gamma-aminobutyric acid) decreased significantly in the 10.0mg Al3+/(Kg·BW) group. This present study shows evidence that the disorder of amino acid neurotransmitters system plays an important role in the impairment of learning and memory of rats induced by aluminum.

scholarly journals Role of oxidative stress in anxiety‐like behavior and learning and memory impairment in a rat model of social stress

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Gaurav Patki ◽  
Farida Allam ◽  
Ritu Bohat ◽  
Faizan Jafri ◽  
Mohammad Saleem ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Learning And Memory ◽  
Rat Model ◽  
Social Stress ◽  
Memory Impairment

Role of hippocampal NR1 receptor in learning and memory impairment

2009 ◽  
Vol 65 ◽  
pp. S8
Author(s):  
Seiichiro Jinde ◽  
Kazu Nakazawa
Keyword(s):  
Learning And Memory ◽  
Memory Impairment

miR-124-3p Ameliorates Isoflurane-Induced Learning and Memory Impairment via Targeting STAT3 and Inhibiting Neuroinflammation

2021 ◽  
pp. 1-7
Author(s):  
Fenghua Liu ◽  
Fengyu Qiu ◽  
Huayong Chen
Keyword(s):  
Learning And Memory ◽  
Memory Impairment ◽  
Potential Role ◽  
Luciferase Reporter ◽  
Enzyme Linked Immunosorbent Assay ◽  
Spatial Learning And Memory ◽  
Factor Α ◽  
Necrosis Factor ◽  
Dual Luciferase Reporter Assay

<b><i>Introduction:</i></b> Substantial evidence has indicated that isoflurane leads to learning and memory impairment. This study was designed to investigate the potential role of microRNA-124-3p (miR-124-3p) in isoflurane-induced learning and memory impairment in rats. <b><i>Methods:</i></b> Spatial learning and memory of rats were estimated by the Morris water maze (MWM) test after the construction of isoflurane-treated models. qRT-PCR was performed to assess the expression levels of miR-124-3p. The levels of interleukin-1β, interleukin-6, and tumor necrosis factor-α in the hippocampal tissues were determined by enzyme-linked immunosorbent assay. The luciferase activity was determined by using a dual-luciferase reporter assay system. <b><i>Results:</i></b> The higher escape latency and lower time spent in the original quadrant were shown in isoflurane-treated rats compared with the control rats. Moreover, treatment with isoflurane could induce neuroinflammation, and miR-124-3p was poorly expressed in the hippocampal tissue of isoflurane-treated rats. Furthermore, STAT3 is a functional target of miR-124-3p, and inflammatory cytokine level was downregulated by miR-124-3p. <b><i>Discussion/Conclusion:</i></b> Combining the results of the current study demonstrates that miR-124-3p may have pivotal roles in improving isoflurane-induced learning and memory impairment via targeting STAT3 and inhibiting neuroinflammation.

Hypobaric Hypoxia-Induced Learning and Memory Impairment: Elucidating the Role of Small Conductance Ca2+-Activated K+ Channels

Neuroscience ◽  
2018 ◽  
Vol 388 ◽  
pp. 418-429 ◽  
Author(s):  
Neetu Kushwah ◽  
Vishal Jain ◽  
Aastha Dheer ◽  
Rahul Kumar ◽  
Dipti Prasad ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Memory Impairment ◽  
Hypobaric Hypoxia ◽  
K Channels ◽  
Small Conductance
Sign in / Sign up

Export Citation Format

Share Document