Sardine oil loaded vanillic acid grafted chitosan microparticles improves the in vivo antioxidant, haematological and lipid profile

2022 ◽  
Author(s):  
Kalladathvalappil Venugopalan Vishnu ◽  
Kizhakkeppurath Kumaran Ajeeshkumar ◽  
Ramadevi Gopakumar Lekshmi ◽  
Niladri Sekhar Chatterjee ◽  
Balaraman Ganesan ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Vanillic Acid ◽  
Chitosan Microparticles ◽  
Sardine Oil

Effects of saffron and crocin on lipid profile: A systematic review of in vivo studies

2020 ◽  
Vol 315 ◽  
pp. e165
Author(s):  
I.N. Abd Rahim ◽  
N.A. Mohd Kasim ◽  
R. Isa
Keyword(s):  
Systematic Review ◽  
Lipid Profile ◽  
In Vivo Studies

scholarly journals Effects of retinoid therapy on insulin sensitivity, lipid profile and circulating adipocytokines

2006 ◽  
Vol 154 (1) ◽  
pp. 83-86 ◽  
Author(s):  
S Corbetta ◽  
R Angioni ◽  
A Cattaneo ◽  
P Beck-Peccoz ◽  
A Spada
Keyword(s):  
Insulin Sensitivity ◽  
Glucose Metabolism ◽  
Lipid Profile ◽  
Oral Treatment ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Glucose And Lipid Metabolism ◽  
Cholesterol Levels

Objective: In vitro and in vivo models indicate that all-trans retinoic acids influence glucose and lipid metabolism. We aimed to evaluate the effects of chronic treatment with acitretin, an all-trans retinoic acid, on glucose metabolism, lipid profile and adiponectin and resistin levels. Design: Ten normoglycemic, normolipemic patients affected with psoriasis vulgaris were studied before and after 1 and 3 months of oral treatment with 35 μg of acitretin. Methods: Glucose metabolism, lipid profile, and adiponectin and resistin levels were evaluated in basal conditions and after acitretin treatment. Ten healthy subjects matched for age, body mass index (BMI) and insulin sensitivity were studied as controls. Results: One-month acitretin treatment reduced psoriasis activity, insulin sensitivity, evaluated as QUICKI values (0.364 ± 0.034 versus 0.329 ± 0.051; P < 0.05) and HOMA-IR index (1.53 ± 0.73 versus 2.59 ± 1.41; P < 0.05), and high-density lipoprotein (HDL)-cholesterol levels (45.2 ± 11.7 versus 39.4 ± 10.4 mg/dl; P = 0.01). The impairment in glucose and lipid homeostasis was transient and not associated to BMI variations. Adiponectin levels did not change during the treatment, while resistin levels, which were higher in untreated patients than in controls (9.4 ± 4.4 versus 6.2 ± 2.1 ng/ml; P = 0.05), fell within the normal range after 1 and 3 months of therapy. The normalization of resistin levels occurred without significant changes in circulating tumor necrosis factor α (TNFα) levels, which persisted elevated throughout the treatment. Conclusions: Treatment with a low dose of acitretin induced a mild, transient reduction of insulin sensitivity and HDL-cholesterol levels that was not related to modifications of adiponectin, resistin and TNFα levels. Although the role of resistin in humans remains elusive, the levels of this adipocytokine seem to be affected, at least in part, by retinoids.

Formulation and Characterization of Atropine Sulfate in Albumin–Chitosan Microparticles for In Vivo Ocular Drug Delivery

2015 ◽  
Vol 104 (5) ◽  
pp. 1677-1690 ◽  
Author(s):  
Richard T. Addo ◽  
Kwame G. Yeboah ◽  
Rodney C. Siwale ◽  
Aladin Siddig ◽  
Alphia Jones ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Atropine Sulfate ◽  
Ocular Drug Delivery ◽  
Chitosan Microparticles

scholarly journals Lipid profile of bovine grade-1 blastocysts produced either in vivo or in vitro before and after slow freezing process

2021 ◽  
Author(s):  
Sarah Janati Idrissi ◽  
Daniel Le Bourhis ◽  
Antoine Lefevre ◽  
Patrick Emond ◽  
Laurene Le Berre ◽  
...  
Keyword(s):  
Lipid Profile ◽  
High Resolution Mass Spectrometry ◽  
High Sensitivity ◽  
Culture Conditions ◽  
Slow Freezing ◽  
Freezing Process ◽  
Before And After ◽  
Lipid Enrichment

Abstract Currently, in vitro embryo production (IVP) is successfully commercially applied in cattle. However, the high sensitivity of embryos to cryopreservation in comparison to in vivo (IVD) embryos slows the dissemination of this biotechnology. Reduced cryotolerance is frequently associated with lipid accumulation in the cytoplasm mainly due to in vitro culture conditions. The objective of this study was to evaluate the lipid composition of biopsied and sexed embryos, produced either in vivo or in vitro from the same Holstein heifers before and after a slow freezing protocol. Lipid extracts were analysed by liquid chromatography-high resolution mass spectrometry, which enabled the detection of 496 features. Our results highlighted a lipid enrichment of IVP embryos in triglycerides and oxidised glycerophospholipids and a reduced abundance in glycerophospholipids. The slow freezing process affected the lipid profiles of IVP and IVD embryos similarly. Lysophosphatidylcholine content was reduced when embryos were frozen/thawed. In conclusion, the embryonic lipid profile is impacted by IVP and slow freezing protocols but not by sex. Lysophosphatidylcholine seemed highly sensitive to cryopreservation and might contribute to explain the lower quality of frozen embryos. Further studies are required to improve embryo freezability by modulating the lipidome.

High-Payload chitosan microparticles for the colonic delivery of quercetin: Development and in-vivo evaluation in a rabbit colitis model

2020 ◽  
Vol 58 ◽  
pp. 101832 ◽  
Author(s):  
Abdelrahman M. Helmy ◽  
Mahmoud Elsabahy ◽  
Mahmoud Abd-Elkareem ◽  
Elsayed A. Ibrahim ◽  
Ghareb M. Soliman
Keyword(s):  
Colonic Delivery ◽  
In Vivo Evaluation ◽  
Chitosan Microparticles ◽  
High Payload ◽  
Colitis Model

Serum Lipid Profile in Sheep Fed Diet Incorporated with Feed Additives

2019 ◽  
Vol 15 (01) ◽  
pp. 31-35
Author(s):  
Yasir A Beigh ◽  
Abdul M Ganai ◽  
Showkeen Muzamil ◽  
Danish M Mir ◽  
Haidar A Ahmad ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Total Cholesterol Level ◽  
Nutrient Digestibility ◽  
Feed Additives ◽  
Serum Lipid Profile ◽  
Feed Additive ◽  
Feeding Trial ◽  
Beneficial Effects

feeding trial to study the supplementation effect of exogenous fibrolytic enzymes (EFE) cocktail and wormwood herb on serum lipid profile was conducted for 90 days in twenty crossbred lambs that were divided into four equal groups viz. T0 (Control) and T1, T2 and T3 (treatment groups). T0 received total mixed diet (TMR) without any supplementation, while in treatments groups TMR was supplemented either with EFE cocktail alone @ 0.60% (T1) or wormwood herb alone @ 4.50% (T2) and in a combination of the two feed additives (T3). At the end of the feeding trial, 6 days of digestibility trial was carried out to assess the supplementation effect in vivo on nutritional parameters and serum total lipids and different lipoprotein fractions were carried out at the start (0 d) and subsequently at monthly intervals of the experiment (30, 60 and 90 d). Nutrient digestibility, content as well intake were significantly higher in groups fed diets supplemented with the feed additives either alone (p less than 0.05) or in-combination (p less than 0.01). No significant effect was observed on the total cholesterol level at any point of evaluation, and on total triglycerides level-up to 30 d, but significant reduction was noted in T2 at 60 (p less than 0.05) and 90 (p less than 0.01) days as compared to T1. Significant (p less than 0.01) effect on HDL level was evident as elevated in T2 while reduced in T1 at day 60 and 90. In contrast, LDL values were reduced in T2 and elevated in T1 group at day 30 (p less than 0.05), 60 and 90 (p less than 0.01). VLDL levels did not change among the groups up to 30 d, whereas reduced at day 60 (p less than 0.05) and 90 (p less than 0.01) in T2 as compared to T1. Lowest (p less than 0.01) AI value was observed in the T2 group at day 90 compared to other groups. It was concluded that dietary incorporation of wormwood herb as a feed additive for sheep improved nutritional status along with health beneficial effects when supplemented alone.

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