Long-Term Follow-Up in a Girl with Cystic Fibrosis and Diabetes Since the First Year of Life

Infant formulae are the only alternatives to breast milk for infants who are unable to continue breastfeeding through the first year of life. They aim to provide formula-fed infants with the same structural and functional benefits observed in breastfed infants. To achieve this, bioactive nutrients have been added to infant formulae in recent years: long-chain polyunsaturated fatty acids for neurodevelopment; probiotics and prebiotics for local gastrointestinal defence; and nucleotides for promoting the immune response. Changes in protein quantity and quality allow infant formulae to achieve a balance between providing the correct plasma amino acid profile and reducing the protein intake, which could prevent obesity in later life. Hydrolysed proteins may help prevent atopic disorders. Many short-term trials have been published but long-term follow-up data are needed in infants who have been fed the newer infant formulae, to fully understand the role of bioactive nutrients.

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Systematic review of the healthcare cost of bronchopulmonary dysplasia

BMJ Open ◽

10.1136/bmjopen-2020-045729 ◽

2021 ◽

Vol 11 (8) ◽

pp. e045729

Author(s):

Jhangir Humayun ◽

Chatarina Löfqvist ◽

David Ley ◽

Ann Hellström ◽

Hanna Gyllensten

Keyword(s):

Systematic Review ◽

Quality Assessment ◽

Preterm Infants ◽

Bronchopulmonary Dysplasia ◽

Gestational Age ◽

First Year ◽

Long Term Follow Up ◽

First Year Of Life

ObjectivesTo determine the costs directly or indirectly related to bronchopulmonary dysplasia (BPD) in preterm infants. The secondary objective was to stratify the costs based on gestational age and/or birth weight.DesignSystematic literature review.SettingPubMed and Scopus were searched on 3 February 2020. Studies were selected based on eligibility criteria by two independent reviewers. Included studies were further searched to identify eligible references and citations.Two independent reviewers extracted data with a prespecified data extraction sheet, including items from a published checklist for quality assessment. The costs in the included studies are reported descriptively.Primary outcome measureCosts of BPD.ResultsThe 13 included studies reported the total costs or marginal costs of BPD. Most studies reported costs during birth hospitalisation (cost range: Int$21 392–Int$1 094 509 per child, equivalent to €19 103–€977 397, in 2019) and/or during the first year of life. One study reported costs during the first 2 years; two other studies reported costs later, during the preschool period and one study included a long-term follow-up. The highest mean costs were associated with infants born at extremely low gestational ages. The quality assessment indicated a low risk of bias in the reported findings of included studies.ConclusionsThis study was the first systematic review of costs associated with BPD. We confirmed previous reports of high costs and described the long-term follow-up necessary for preterm infants with BPD, particularly infants of very low gestational age. Moreover, we identified a need for studies that estimate costs outside hospitals and after the first year of life.PROSPERO registration numberCRD42020173234.

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Adult outcome after neurosurgical treatment of brain tumours in the first year of life: long-term follow-up of a single consecutive institutional series of 34 patients

Acta Neurochirurgica ◽

10.1007/s00701-019-04014-z ◽

2019 ◽

Vol 161 (9) ◽

pp. 1793-1798

Author(s):

Tryggve Lundar ◽

Bernt Johan Due-Tønnessen ◽

Radek Frič ◽

Petter Brandal ◽

Einar Stensvold ◽

...

Keyword(s):

Brain Tumours ◽

First Year ◽

Adult Outcome ◽

Long Term Follow Up ◽

Neurosurgical Treatment ◽

First Year Of Life

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Bilateral asymptomatic incidental vulvar/labial hemangioma: Kissing Hemangiomas

Urogynaecologia ◽

10.4081/uij.2011.e10 ◽

2011 ◽

Vol 25 (1) ◽

pp. 10

Author(s):

Pankaj P. Dangle ◽

Lopa K. Pandya IV ◽

Casimir F. Firlit

Keyword(s):

Plastic Surgery ◽

Rare Case ◽

Watchful Waiting ◽

Treatment Approach ◽

First Year ◽

Labia Majora ◽

Long Term Follow Up ◽

First Year Of Life

We present a rare case of genital hemangiomas. Generally, hemangiomas are present at birth or in the first year of life and completely resolve by age 10. Most are asymptomatic. We present an 11 year old girl who presented with incidentally diagnosed asymptomatic bilateral hemangiomas on her labia majora. The treatment for genital hemangiomas is not well defined in the literature. We elected to choose watchful waiting as our treatment approach at this time. Long term follow-up is necessary with intention to intervene with multispeciality approach involving gynaecology and plastic surgery to avoid any disfigurement of the local anatomy.

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Epilepsy surgery of posterior quadrant dysplasia in the first year of life: Experience of a single Centre with long term follow-up

Seizure ◽

10.1016/j.seizure.2010.09.015 ◽

2011 ◽

Vol 20 (1) ◽

pp. 27-33 ◽

Cited By ~ 5

Author(s):

F. Novegno ◽

L. Massimi ◽

D. Chieffo ◽

D. Battaglia ◽

P. Frassanito ◽

...

Keyword(s):

Epilepsy Surgery ◽

Life Experience ◽

First Year ◽

Single Centre ◽

Posterior Quadrant ◽

Long Term Follow Up ◽

First Year Of Life

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Muenke syndrome: long-term outcome of a syndrome-specific treatment protocol

Journal of Neurosurgery Pediatrics ◽

10.3171/2019.5.peds1969 ◽

2019 ◽

Vol 24 (4) ◽

pp. 415-422 ◽

Cited By ~ 2

Author(s):

Bianca K. den Ottelander ◽

Robbin de Goederen ◽

Marie-Lise C. van Veelen ◽

Stephanie D. C. van de Beeten ◽

Maarten H. Lequin ◽

...

Keyword(s):

Treatment Protocol ◽

First Year ◽

Ventricular Size ◽

Term Outcome ◽

Long Term Outcome ◽

Skull Growth ◽

Muenke Syndrome ◽

First Year Of Life

OBJECTIVEThe authors evaluated the long-term outcome of their treatment protocol for Muenke syndrome, which includes a single craniofacial procedure.METHODSThis was a prospective observational cohort study of Muenke syndrome patients who underwent surgery for craniosynostosis within the first year of life. Symptoms and determinants of intracranial hypertension were evaluated by longitudinal monitoring of the presence of papilledema (fundoscopy), obstructive sleep apnea (OSA; with polysomnography), cerebellar tonsillar herniation (MRI studies), ventricular size (MRI and CT studies), and skull growth (occipital frontal head circumference [OFC]). Other evaluated factors included hearing, speech, and ophthalmological outcomes.RESULTSThe study included 38 patients; 36 patients underwent fronto-supraorbital advancement. The median age at last follow-up was 13.2 years (range 1.3–24.4 years). Three patients had papilledema, which was related to ophthalmological disorders in 2 patients. Three patients had mild OSA. Three patients had a Chiari I malformation, and tonsillar descent < 5 mm was present in 6 patients. Tonsillar position was unrelated to papilledema, ventricular size, or restricted skull growth. Ten patients had ventriculomegaly, and the OFC growth curve deflected in 3 patients. Twenty-two patients had hearing loss. Refraction anomalies were diagnosed in 14/15 patients measured at ≥ 8 years of age.CONCLUSIONSPatients with Muenke syndrome treated with a single fronto-supraorbital advancement in their first year of life rarely develop signs of intracranial hypertension, in accordance with the very low prevalence of its causative factors (OSA, hydrocephalus, and restricted skull growth). This illustrates that there is no need for a routine second craniofacial procedure. Patient follow-up should focus on visual assessment and speech and hearing outcomes.

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P096 Long-term follow-up of adolescent and adult patients with cystic fibrosis: a single centre's experience

Journal of Cystic Fibrosis ◽

10.1016/s1569-1993(21)01122-x ◽

2021 ◽

Vol 20 ◽

pp. S68

Author(s):

A.I. Yilmaz ◽

G. Ünal ◽

B.S. Kibar ◽

P. Sevgi ◽

O. Eĝil ◽

...

Keyword(s):

Cystic Fibrosis ◽

Adult Patients ◽

Long Term Follow Up

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Long-term Follow-up in Adult Patients with Cystic Fibrosis and Deep Intronic Splicing Variants

Archivos de Bronconeumología (English Edition) ◽

10.1016/j.arbr.2020.11.017 ◽

2021 ◽

Vol 57 (7) ◽

pp. 501-503

Author(s):

Antonio Álvarez ◽

Karina Loor ◽

Paula Fernández-Alvarez ◽

Silvia Gartner ◽

Eva Polverino ◽

...

Keyword(s):

Cystic Fibrosis ◽

Adult Patients ◽

Splicing Variants ◽

Long Term Follow Up

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Three-Year Clinical Follow-Up of Children Intrauterine Exposed to Zika Virus

Viruses ◽

10.3390/v13030523 ◽

2021 ◽

Vol 13 (3) ◽

pp. 523

Author(s):

Rosa Estela Gazeta ◽

Ana Paula Antunes Pascalicchio Bertozzi ◽

Rita de Cássia de Aguirre Bernardes Dezena ◽

Andrea Cristina Botelho Silva ◽

Thamirys Cosmo Gillo Fajardo ◽

...

Keyword(s):

Zika Virus ◽

Clinical Manifestations ◽

Laboratory Diagnosis ◽

Autism Spectrum ◽

First Year ◽

Cognitive Delay ◽

Long Term Follow Up ◽

Simplex Virus ◽

First Year Of Life

Congenital Zika virus (ZIKV) infection may present with a broad spectrum of clinical manifestations. Some sequelae, particularly neurodevelopmental problems, may have a later onset. We conducted a prospective cohort study of 799 high-risk pregnant women who were followed up until delivery. Eighty-three women and/or newborns were considered ZIKV exposed and/or infected. Laboratory diagnosis was made by polymerase chain reaction in the pregnant mothers and their respective newborns, as well as Dengue virus, Chikungunya virus, and ZIKV serology. Serology for toxoplasmosis, rubella, cytomegalovirus, herpes simplex virus, and syphilis infections were also performed in microcephalic newborns. The newborns included in the study were followed up until their third birthday. Developmental delay was observed in nine patients (13.2%): mild cognitive delay in three patients, speech delay in three patients, autism spectrum disorder in two patients, and severe neurological abnormalities in one microcephalic patient; sensorineural hearing loss, three patients and dysphagia, six patients. Microcephaly due to ZIKV occurred in three patients (3.6%). Clinical manifestations can appear after the first year of life in children infected/exposed to ZIKV, emphasizing the need for long-term follow-up.

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Long-term prognosis

10.1093/med/9780198722366.003.0016 ◽

2018 ◽

Author(s):

Halvor Naess

Keyword(s):

Risk Factors ◽

Cerebral Infarction ◽

First Year ◽

Modified Rankin Scale ◽

Annual Average ◽

Long Term Follow Up ◽

Traditional Risk Factors ◽

Long Term Prognosis

Knowledge of prognosis is important for patients in the prime of life in order to make informed decisions about treatment, choice of education, and profession. Median first-year mortality after first-ever cerebral infarction among young adults is about 4% while median annual average mortality after the first year is about 1.7%. Likewise, median first-year recurrence rate of cerebral infarction is 2% and thereafter 1.5% per year. Risk factors for recurrent cerebral infarction include hypertension, diabetes mellitus, symptomatic atherosclerosis, and smoking. Recurrent cerebral infarction and mortality are associated with increasing number of traditional risk factors. About 10% of patients develop post-stroke seizures within 6 years of the acute stroke. Almost 90% of patients report good functional outcome (modified Rankin Scale score ≤2) on long-term follow-up, but up to 30–50% of patients do not resume employment. Many patients have cognitive impairment. Fatigue and depression are also common on long-term follow-up.

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