Background:
Objective: Various natural gums can be synergistically used in
nanoparticulate drug delivery systems to treat cardiovascular diseases. Nanotechnology has
been integrated into healthcare in terms of theranostics. In this review, we consider various
natural gums that can be used for the preparation of nanoparticles and their role to treat cardiovascular
disease.
Methods:
Nanoparticles can carry drugs at nanoscales and deliver them to the targeted sites
with the desired pattern of drug release. They have specialized uptake mechanisms (e.g. - absorptive
endocytosis) which improve the bioavailability of drugs.
Results:
By considering cardiovascular diseases at the molecular level, it is possible to modify
the materials with nanotechnology and apply nano-formulations efficiently as compared
with conventional preparations, due to the fact that the extracellular matrix (ECM) comprises
components at the nanoscale range. The interactions of ECM components with cellular components
occur at the nanoscale, therefore the nanomaterials have the potential to maintain the
nanoscale properties of cells. The synthetic materials used to develop the nanoparticulate
drug delivery system may cause toxicity.
Conclusion:
This problem can be overcome by using natural polymers. Natural gums can be
used in nanoparticulate drug delivery systems as reducing and stabilizing agents and in some
cases; they may directly or indirectly influence the rate of drug release and absorption from
the preparation.
Novel Drug Delivery Systems in Management of Cardiovascular Diseases
