Description of Gas-Phase Ion/Neutral Interactions in Differential Ion Mobility Spectrometry: CV Prediction Using Calibration Runs

2014 ◽  
Vol 25 (9) ◽  
pp. 1610-1621 ◽  
Author(s):  
David Auerbach ◽  
Julia Aspenleiter ◽  
Dietrich A. Volmer
Keyword(s):  
Gas Phase ◽  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Differential Ion Mobility Spectrometry ◽  
Gas Phase Ion

Analysis of hazardous chemicals by “stand alone” drift tube ion mobility spectrometry: a review

2020 ◽  
Vol 12 (9) ◽  
pp. 1163-1181 ◽  
Author(s):  
S. Armenta ◽  
F. A. Esteve-Turrillas ◽  
M. Alcalà
Keyword(s):  
Electric Field ◽  
Gas Phase ◽  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Drift Tube ◽  
Hazardous Chemicals ◽  
Ion Separation ◽  
Gas Phase Ion

Drift tube-ion mobility spectrometry (DT-IMS) is a widely used technique for the determination of semi-volatile hazardous chemicals based on gas phase ion separation under an electric field by differences in ion mobilities.

scholarly journals Direct Measurement of Light and Heavy Antibody Chains Using Differential Ion Mobility Spectrometry and Middle-Down Mass Spectrometry

2019 ◽  
Author(s):  
Rafael D Melani ◽  
Kristina Srzentić ◽  
Vincent R Gerbasi ◽  
John P McGee ◽  
Romain Huguet ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gas Phase ◽  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Asymmetric Waveform ◽  
Fast Fashion ◽  
Differential Ion Mobility Spectrometry ◽  
Ms Analysis ◽  
Polypeptide Sequence ◽  
Liquid Fractionation

AbstractThe analysis of monoclonal antibodies (mAbs) by a middle-down approach is a growing field that attracts the attention of many researchers and biopharma companies. Usually, liquid fractionation techniques are used to separate mAbs polypeptides chains before mass spectrometry (MS) analysis. Gas-phase fractionation techniques such as high-field asymmetric waveform ion mobility spectrometry (FAIMS) can replace liquid-based separations and reduce both analysis time and cost. Here, we present a rapid FAIMS tandem MS method capable of characterizing the polypeptide sequence of mAbs light (Lc) and heavy (Hc) chains in an unprecedented, easy, and fast fashion. This new method uses commercially available instruments and takes ∼ 24 minutes —40-60% faster than regular LC-MS/MS analysis — to acquire fragmentation data using different dissociation methods.

scholarly journals High-Definition Differential Ion Mobility Spectrometry with Resolving Power up to 500

2012 ◽  
Vol 24 (1) ◽  
pp. 109-114 ◽  
Author(s):  
Alexandre A. Shvartsburg ◽  
Tom A. Seim ◽  
William F. Danielson ◽  
Randy Norheim ◽  
Ronald J. Moore ◽  
...  
Keyword(s):  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Resolving Power ◽  
High Definition ◽  
Differential Ion Mobility Spectrometry

scholarly journals Gas Phase Stability of Protein Ions in a Cyclic Ion Mobility Spectrometry Traveling Wave Device

2019 ◽  
Vol 91 (12) ◽  
pp. 7554-7561 ◽  
Author(s):  
Charles Eldrid ◽  
Jakub Ujma ◽  
Symeon Kalfas ◽  
Nick Tomczyk ◽  
Kevin Giles ◽  
...  
Keyword(s):  
Gas Phase ◽  
Ion Mobility Spectrometry ◽  
Phase Stability ◽  
Ion Mobility ◽  
Traveling Wave ◽  
Protein Ions ◽  
Wave Device
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