Cerebrospinal fluid white cell count: discriminatory or otherwise for enteroviral meningitis in infants and young children?

2015 ◽  
Vol 22 (2) ◽  
pp. 213-217 ◽  
Author(s):  
Natalie Woon Hui Tan ◽  
Elis Yuexian Lee ◽  
Gloria Mei Chin Khoo ◽  
Nancy Wen Sim Tee ◽  
Subramania Krishnamoorthy ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Young Children ◽  
Cell Count ◽  
White Cell Count ◽  
White Cell ◽  
Enteroviral Meningitis ◽  
Infants And Young Children

Pragmatic and evidence-based approach to paediatric cerebrospinal fluid reference limits for white cell count and concentrations of total protein and glucose

2018 ◽  
Vol 71 (10) ◽  
pp. 932-935 ◽  
Author(s):  
Nicky Josman ◽  
Nancy W S Tee ◽  
Matthias Maiwald ◽  
Liat Hui Loo ◽  
Clement K M Ho
Keyword(s):  
Cerebrospinal Fluid ◽  
Cell Count ◽  
Total Protein ◽  
Clinical Laboratory ◽  
White Cell Count ◽  
Reference Intervals ◽  
White Cell ◽  
Invasive Procedures ◽  
Paediatric Hospital ◽  
Reference Limits

BackgroundIt is often impractical for each laboratory to establish its own paediatric reference intervals. This is particularly true for specimen types collected using invasive procedures, for example, cerebrospinal fluid (CSF).MethodsPublished CSF reference intervals for white cell count, and concentrations of total protein and glucose were reviewed by stakeholders in a paediatric hospital. Consensus reference intervals for the three CSF parameters were then subjected to verification using guidelines from the Clinical Laboratory Standards Institute and residual CSF specimens.ResultsConsensus paediatric reference intervals adapted from published studies with minor modifications were locally verified as follows. White cell count (x106 cells/L): 0–20 (<1 month); 0–10 (1–2 months); 0–5 (>2 months). Total protein (g/L): 0.3–1.2 (<1 month); 0.2–0.6 (1–3 months); 0.1–0.4 (>3 months). Glucose (mmol/L): 2.0–5.6 (<6 months); 2.4–4.3 (6 months or older).

scholarly journals STUDIES ON ACUTE DISSEMINATED ENCEPHALOMYELITIS PRODUCED EXPERIMENTALLY IN RHESUS MONKEYS

1951 ◽  
Vol 93 (6) ◽  
pp. 615-633 ◽  
Author(s):  
Elvin A. Kabat ◽  
Abner Wolf ◽  
Ada E. Bezer ◽  
Jean P. Murray
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Rhesus Monkey ◽  
Cell Count ◽  
Total Protein ◽  
Rhesus Monkeys ◽  
Gamma Globulin ◽  
White Cell Count ◽  
Acute Disseminated Encephalomyelitis ◽  
White Cell

The white cell count, total protein, gamma globulin, and percentage of gamma globulin in the cerebrospinal fluid of monkeys with acute disseminated encephalomyelitis produced by the injection of brain emulsions with adjuvants have been studied. The acute phase of the disease is characterized by a rise in the white cell count, total protein, and gamma globulin in the cerebrospinal fluid. In some instances the percentage of gamma globulin, to the total protein may be normal while in others it is elevated. As the acute process subsides, the total protein declines and animals frequently show an increase in the percentage of gamma globulin to total protein. The relation of the cerebrospinal fluid findings in acute disseminated encephalomyelitis in the rhesus monkey to those in human multiple sclerosis is discussed.

Fever and Petechiae in Children

PEDIATRICS ◽  
1990 ◽  
Vol 86 (5) ◽  
pp. 807-807
Author(s):  
JAMES D. KELLNER
Keyword(s):  
Cerebrospinal Fluid ◽  
Cell Count ◽  
Clinical Features ◽  
White Cell Count ◽  
White Cell ◽  
Clinical Impression ◽  
Bacterial Disease

To the Editor.— I read the article on "Fever and Petechiae in Children" by Baker et al1 with great interest. The results of Baker et al support the teaching I have received and my clinical impression that children having fever and petechiae most often do not have meningococcemia. Further, it appears that consideration of initial clinical features, peripheral white cell count, and examination of cerebrospinal fluid should allow a definitive assessment of whether invasive bacterial disease is present.

Leucocytes and Thrombosis

1973 ◽  
Vol 30 (01) ◽  
pp. 036-046 ◽  
Author(s):  
D.C Banks ◽  
J.R.A Mitchell
Keyword(s):  
Cell Count ◽  
White Cell Count ◽  
Cell Loss ◽  
White Cell ◽  
Structural Resemblance ◽  
The Masses

SummaryWhen heparinised blood is rotated in a glass flask at 37°C. the white cell count falls and it has been shown that this is due to the adherence and aggregation of polymorphonuclear white cells on the wall of the flask. The masses formed bear a close structural resemblance to thrombi and the mechanisms involved in white cell loss during rotation may therefore increase our knowledge of the thrombotic process.

An Assessment of Red Cell Deformability Using a Simple Filtration Method

1979 ◽  
Author(s):  
M Drummond ◽  
G Lowe ◽  
J Belch ◽  
C Forbes ◽  
J Barbenel
Keyword(s):  
Cell Count ◽  
Shear Viscosity ◽  
White Cell Count ◽  
White Cell ◽  
Red Cell ◽  
Cell Deformability ◽  
Red Cell Deformability ◽  
Simple Method ◽  
Filtration Method ◽  
Significant Difference

We investigated the reproducibility and validity of a simple method of measuring red cell deformability (filtration of whole blood through 5 µ sieves) and its relationship to haematocrit, blood viscosity, fibrinogen, white cell count, sex and smoking. The mean coefficient of variation in normals was 3. 7%. Tanned red cells showed marked loss of deformability. Blood filtration rate correlated with haematocrit (r = 0. 99 on dilution of samples, r = 0. 7 in 120 normals and patients). After correction for haematocrit, deformability correlated with high shear viscosity, but not low shear viscosity, fibrinogen or white cell count. In 60 normals there was no significant difference between males and females, or smokers and non-smokers, but in 11 smokers there was an acute fall in deformability after smoking 3 cigarettes (p<0. 05). Reduced deformability was found in acute myocardial infarction (n = 15, p<0. 01) and chronic peripheral arterial disease (n = 15, p<0. 01). The technique is reproducible, detects rigid cells and appears useful in the study of vascular disease.

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