Cerebral venous thrombosis: a rare complication of herpes simplex encephalitis

2019 ◽  
Vol 26 (1) ◽  
pp. 114-117
Author(s):  
M. Vedani ◽  
O. Toubas ◽  
M. Hentzien ◽  
A. Brunet ◽  
L. Andreoletti ◽  
...  
Keyword(s):  
Herpes Simplex ◽  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Herpes Simplex Encephalitis ◽  
Rare Complication

Cerebral venous thrombosis associated with tuberculous meningitis: a rare complication of a common disease

2015 ◽  
Vol 157 (10) ◽  
pp. 1679-1680 ◽  
Author(s):  
Raghvendra Ramdasi ◽  
Amit Mahore ◽  
Juhi Kawale ◽  
Smita Thorve
Keyword(s):  
Venous Thrombosis ◽  
Tuberculous Meningitis ◽  
Cerebral Venous Thrombosis ◽  
Rare Complication ◽  
Common Disease

scholarly journals Cerebral venous thrombosis and Covid 19: Literature review

2021 ◽  
Vol 11 (2) ◽  
pp. 57-68
Author(s):  
Carlos Alexandre Martins Zicarelli ◽  
Jonathan Vinicius Martins ◽  
Wesley Vieira Doni ◽  
Rafael Rodrigues Pinheiro dos Santos ◽  
Ana Carla Mondek Rampazzo ◽  
...  
Keyword(s):  
Literature Review ◽  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Sinus Thrombosis ◽  
Rare Complication ◽  
Clinical Manifestations ◽  
Risk Of Death ◽  
Cranial Sinus Thrombosis ◽  
Stent Retrievers ◽  
Low Incidence

Introduction: Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) was first detected in December 2019 in the city of Wuhan, China, and has since taken on worldwide proportions. It is known that individuals with Coronavirus disease-19 (COVID-19) have systemic clinical manifestations. Among the multisystemic effects, cerebral venous thrombosis (CVT) is responsible for high mortality rates. In this sense, understanding the association between CVT and SARS-CoV-2 infection directly impacts the disease's morbidity and mortality. Methodology: Literature review in the PubMed and Embase databases, with the following search terms: “COVID-19”, “SARS-CoV-2”, “Venous thromboembolism”, “Thrombosis”, “Cerebral Venous Thrombosis”, “Intracranial Sinus Thrombosis” and “Cranial Sinus Thrombosis”. The selected articles were written in English, which addressed the various aspects of COVID-19. Results and discussion: CVT are a rare complication of COVID-19, with an incidence between 0.02 to 1% of hospitalized patients. However, it can reach about 75% of mortality in affected individuals. Pathophysiology seems to be associated with the state of hypercoagulability and the systemic inflammatory process resulting from viral infection. Thus, recent studies show a consensus on the early anticoagulation of patients affected by the virus, to reduce mortality in these cases. However, the differences between the types of anticoagulation, Low Molecular Weight Heparin (LMWH), Unfractionated Heparin (UFH), Dabigatran have not yet been well established, although there is a predilection for the use of LMWH. Also, thrombectomy is a therapeutic intervention option that should be evaluated, due to the risk of additional endothelial injury from the use of stent retrievers. Conclusion: Although it has a relatively low incidence, CVT aggravates the condition and increases the risk of death for patients with COVID-19. Because of this, early diagnosis and evaluation of therapeutic options for CVT are essential for the development of clinical management.

scholarly journals A rare complication of cerebral venous thrombosis during simple percutaneous coronary intervention

Medicine ◽  
2021 ◽  
Vol 100 (4) ◽  
pp. e24008
Author(s):  
Ming Yuan Lo ◽  
Ming-Shiu Chen ◽  
Hsuan-Ming Jen ◽  
Chien-Cheng Chen ◽  
Thau-Yun Shen
Keyword(s):  
Percutaneous Coronary Intervention ◽  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Rare Complication ◽  
Coronary Intervention ◽  
Percutaneous Coronary

scholarly journals Cerebral Venous Thrombosis as Rare Presentation of Herpes Simplex Virus Encephalitis

2019 ◽  
Vol 2019 ◽  
pp. 1-5 ◽  
Author(s):  
José Leite ◽  
Ana Ribeiro ◽  
Diana Gonçalves ◽  
João Sargento-Freitas ◽  
Luís Trindade ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Early Recognition ◽  
Clinical Aspects ◽  
Herpes Simplex Virus Encephalitis ◽  
Prognostic Impact ◽  
Virus Encephalitis ◽  
Simplex Virus

Herpes simplex virus 1 is a prevalent neurotropic pathogen that infects and establishes latency in peripheral sensory neurons. It can migrate into the central nervous system and cause encephalitis. The association between herpes simplex virus encephalitis and cerebral venous thrombosis is rare, with a very limited number of case reports described in the literature, despite the recognized thrombogenic effects of the virus. A 44-year-old man was brought to the emergency department with generalized tonic-clonic seizures requiring sedation and ventilation to control it. Initial brain computed tomography revealed cortical and subcortical edema on the left frontal lobe, and a subsequent contrast-enhanced exam showed absence of venous flow over the anterior half of the superior sagittal sinus. Cerebrospinal fluid polymerase chain reaction was positive for herpes simplex virus type 1, and the patient was started on acyclovir and anticoagulation, with clinical improvement. Acyclovir administration was maintained for 14 days and oral anticoagulation for one year, with no recurrence of thrombotic events or other complications. A well-timed treatment has a validated prognostic impact on herpes simplex encephalitis, making early recognition of its clinical aspects of main importance.

scholarly journals Spontaneous occult intracranial hypotension precipitating life-threatening cerebral venous thrombosis: case report

2018 ◽  
Vol 28 (6) ◽  
pp. 669-678 ◽  
Author(s):  
Avital Perry ◽  
Christopher S. Graffeo ◽  
Waleed Brinjikji ◽  
William R. Copeland ◽  
Alejandro A. Rabinstein ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Intracranial Hypotension ◽  
Primary Repair ◽  
Rare Complication ◽  
External Ventricular Drain ◽  
Spontaneous Intracranial Hypotension ◽  
Mass Effect ◽  
Complete Recovery ◽  
Csf Leak

Spontaneous intracranial hypotension (SIH) is an uncommon headache etiology, typically attributable to an unprovoked occult spinal CSF leak. Although frequently benign, serious complications may occur, including cerebral venous thrombosis (CVT). The objective of this study was to examine a highly complicated case of CVT attributable to SIH as a lens for understanding the heterogeneous literature on this rare complication, and to provide useful, evidence-based, preliminary clinical recommendations. A 43-year-old man presented with 1 week of headache, dizziness, and nausea, which precipitously evolved to hemiplegia. CT venography confirmed CVT, and therapeutic heparin was initiated. He suffered a generalized seizure due to left parietal hemorrhage, which subsequently expanded. He developed signs of mass effect and herniation, heparin was discontinued, and he was taken to the operating room for clot evacuation and external ventricular drain placement. Intraoperatively, the dura was deflated, suggesting underlying SIH. Ventral T-1 CSF leak was identified, which failed multiple epidural blood patches and required primary repair. The patient ultimately made a complete recovery. Systematic review identified 29 publications describing 36 cases of SIH-associated CVT. Among 31 patients for whom long-term neurological outcome was reported, 25 (81%) recovered completely. Underlying coagulopathy/risk factors were identified in 11 patients (31%). CVT is a rare and potentially lethal sequela occurring in 2% of SIH cases. Awareness of the condition is poor, risking morbid complications. Evaluation and treatment should be directed toward identification and treatment of occult CSF leaks. Encouragingly, good neurological outcomes can be achieved through vigilant multidisciplinary neurosurgical and neurocritical care.

When herpes lingers on: A rare complication of acute herpes simplex encephalitis

2021 ◽  
Vol 429 ◽  
pp. 118957
Author(s):  
Lakshminarayanapuram Viswanathan ◽  
Madhu Nagappa ◽  
Doniparthi Seshagiri ◽  
Arimappan Arivazhagan ◽  
Anita Mahadevan ◽  
...  
Keyword(s):  
Herpes Simplex ◽  
Herpes Simplex Encephalitis ◽  
Rare Complication

scholarly journals Kluver-Bucy Syndrome: A Rare Complication of Herpes Simplex Encephalitis

2021 ◽  
Author(s):  
Raquel Costa ◽  
Tiago Mendes ◽  
Joana Fontes ◽  
Marta Pereira ◽  
Carlos Gonçalves
Keyword(s):  
Herpes Simplex ◽  
Herpes Virus ◽  
Herpes Simplex Encephalitis ◽  
Rare Complication ◽  
Memory Deficits ◽  
Cognitive Dysfunctions ◽  
Temporal Lobes ◽  
Rare Syndrome ◽  
Herpès Virus

Kluver-Bucy syndrome (KBS) is a characterized by a group of cognitive dysfunctions that include hypersexuality, placidity, hyperorality, memory deficits and hypermetamorphosis. This syndrome is often seen in pathological states that destroy the temporal lobes, normally bilaterally. Herpes simplex encephalitis (HSE) is one of the causes of KBS, as the herpes virus can cause dysfunction/destruction of the temporal lobes. KBS is a very rare syndrome, with just a few cases described in the literature. We present the case of a 21-year-old-man who was diagnosis with KBS after HSE.

scholarly journals Bacterial meningitis complicated by cerebral venous thrombosis

2020 ◽  
Vol 5 (4) ◽  
pp. 394-401
Author(s):  
Shahrzad S Deliran ◽  
Matthijs C Brouwer ◽  
Jonathan M Coutinho ◽  
Diederik van de Beek
Keyword(s):  
Bacterial Meningitis ◽  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Clinical Characteristics ◽  
Clinical Course ◽  
Rare Complication ◽  
Transverse Sinus ◽  
Causative Pathogen ◽  
Neurologic Deficits ◽  
Nose And Throat

Introduction Community-acquired bacterial meningitis may be complicated by cerebral venous thrombosis (CVT), but this has not systematically been studied. Methods We evaluated clinical characteristics and outcome of CVT in adults with community-acquired bacterial meningitis in a prospective nationwide cohort study of bacterial meningitis (2006–2018) in the Netherlands. Results CVT occurred in 26 of 2220 episodes with bacterial meningitis (1%). The diagnosis of CVT was made on the day of presentation in 15 patients (58%) and during hospital stay in 11 patients after a median of 6 days (IQR 2–7). Sinusitis or otitis was present in 16 of 24 patients (67%). Patients with CVT presented more often in a coma than those without CVT (53 vs. 18%; P = 0.001) and the clinical course was more often complicated by focal neurologic deficits (58 vs. 22%; P < 0.001). Twelve patients of 26 (46%) had parenchymal lesions on neuroimaging, of whom two (8%) were specific for CVT. The transverse sinus was most frequently thrombosed (18 of 26; 69%). Streptococcus pneumoniae was the most common causative pathogen, occurring in 17 of 26 patients (65%). Eleven patients (44%) received anticoagulant therapy with heparin and none of them developed intracerebral hemorrhage during admission. Unfavorable outcome, as defined as a score on the Glasgow Outcome Scale <5, occurred in 14 of 26 patients (54%) and 4 patients (15%) died. Discussion and conclusion CVT is a rare complication of bacterial meningitis and mainly occurs in patients with coma, ear, nose and throat infections, and focal neurologic deficits.

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