Glycerol-based NaDES as green solvents for ultrasound-assisted extraction of phycocyanin from Arthrospira platensis—RSM optimization and ANN modelling

Abstract Byproducts such as orange peel have potential uses because of their bioactive compounds, which are important for their potential to reduce the risk factors of diseases caused by aging. The lack of effective techniques and the high levels of pollution produced by the conventional extraction of bioactive compounds using organic solvents have highlighted the need to enhance the ‘green chemistry’ trend. This study evaluates the use of ultrasound to extract bioactive compounds from orange peel. The antioxidant capacity, phenolic content, ascorbic acid, total carotenoids, and HPLC profile of phenolic compounds from orange peel extracts were obtained by a physicochemical evaluation. The results demonstrate that the optimal conditions for the ultrasound-assisted extraction of bioactive orange peel compounds were a power of 400 W, a time of 30 min, and 50% ethanol in water. These conditions were used to obtain a total carotenoid concentration of 0.63 mg ß-carotene/100 g, vitamin C concentration of 53.78 mg AA/100 g, phenolic concentration of 105.96 mg GAE/100 g, and antioxidant capacity of ORAC = 27.08 mM TE and TEAC = 3.97 mM TE. The major phenolic compound identified in all orange peel extracts was hesperidin, with a maximum concentration of 113.03 ± 0.08 mg/100 g.

Download Full-text

Natural deep eutectic solvents as new green solvents to extract anthraquinones from Rheum palmatum L.

RSC Advances ◽

10.1039/c7ra13581e ◽

2018 ◽

Vol 8 (27) ◽

pp. 15069-15077 ◽

Cited By ~ 15

Author(s):

Y. C. Wu ◽

P. Wu ◽

Y. B. Li ◽

T. C. Liu ◽

L. Zhang ◽

...

Keyword(s):

Deep Eutectic Solvents ◽

Green Solvents ◽

Ultrasound Assisted Extraction ◽

Rheum Palmatum ◽

Assisted Extraction ◽

Natural Deep Eutectic Solvents ◽

Ultrasound Assisted

Natural deep eutectic solvents ultrasound-assisted extraction (NADES-UAE) was applied to extract total anthraquinones from Rheum palmatum L.

Download Full-text

Ultrasound-assisted extraction of phycobiliproteins from Spirulina (Arthrospira) platensis using protic ionic liquids as solvent

Algal Research ◽

10.1016/j.algal.2018.02.021 ◽

2018 ◽

Vol 31 ◽

pp. 454-462 ◽

Cited By ~ 24

Author(s):

Renata Débora Pinto Rodrigues ◽

Felipe Carolino de Castro ◽

Rílvia Saraiva de Santiago-Aguiar ◽

Maria Valderez Ponte Rocha

Keyword(s):

Ionic Liquids ◽

Arthrospira Platensis ◽

Protic Ionic Liquids ◽

Ultrasound Assisted Extraction ◽

Assisted Extraction ◽

Ultrasound Assisted

Download Full-text

Ultrasound-assisted extraction kinetics, fatty acid profile, total phenolic content and antioxidant activity of green solvents' extracted passion fruit oil

International Journal of Food Science & Technology ◽

10.1111/ijfs.12844 ◽

2015 ◽

Vol 50 (8) ◽

pp. 1831-1838 ◽

Cited By ~ 3

Author(s):

Sin Yee Lee ◽

Sin Yin Fu ◽

Gun Hean Chong

Keyword(s):

Antioxidant Activity ◽

Phenolic Content ◽

Total Phenolic ◽

Green Solvents ◽

Extraction Kinetics ◽

Ultrasound Assisted Extraction ◽

Assisted Extraction ◽

Ultrasound Assisted ◽

Fruit Oil ◽

Passion Fruit Oil

Download Full-text

Optimization of Extraction of Bioactive Compounds from Baphicacanthus cusia Leaves by Hydrophobic Deep Eutectic Solvents

Molecules ◽

10.3390/molecules26061729 ◽

2021 ◽

Vol 26 (6) ◽

pp. 1729

Author(s):

Zhiqin Xu ◽

Yini Cai ◽

Qing Ma ◽

Zhimin Zhao ◽

Depo Yang ◽

...

Keyword(s):

Lactic Acid ◽

Medicinal Plants ◽

Bioactive Compounds ◽

Radical Scavenging Activity ◽

Radical Scavenging ◽

Deep Eutectic Solvents ◽

Green Solvents ◽

Ultrasound Assisted Extraction ◽

Assisted Extraction ◽

Ultrasound Assisted

Deep eutectic solvents (DESs) are considered as efficient and green solvents for the extraction of bioactive compounds from medicinal plants. In this work, a novel method of DES-based ultrasound-assisted extraction of bioactive compounds from Baphicacanthus cusia leaves (BCL) was established. Systematic screening and the morphology of the original and treated BCL were observed with scanning electron microscopy to determine the extraction efficiency of different solvents. The extraction conditions were optimized by Box–Behnken design (BBD) tests and the optimal extraction conditions were as follows: lactic acid/L-menthol ratio of 5: 2 (mol/mol), solid–liquid ratio of 80.0 mL/g and temperature of 60.5 °C. The extraction yields of tryptanthrin, indigo and indirubin reached 0.356, 1.744 and 0.562 mg/g, respectively. The results of a 2,2-diphenyl-1-picrylhydrazy (DPPH) radical scavenging activity test indicated the feasibility of DESs in the extraction of bioactive compounds. This study indicated that L-menthol/lactic acid was a green and efficient solvent for the extraction of bioactive compounds from BCL, and DES-based ultrasound-assisted extraction could be used as an effective application strategy for the extraction of bioactive compounds from medicinal plants.

Download Full-text

Lycopene green ultrasound-assisted extraction using edible oil accompany with response surface methodology (RSM) optimization performance: Application in tomato processing wastes

Microchemical Journal ◽

10.1016/j.microc.2019.02.039 ◽

2019 ◽

Vol 146 ◽

pp. 1033-1042 ◽

Cited By ~ 7

Author(s):

Somayeh Rahimi ◽

Mohaddeseh Mikani

Keyword(s):

Response Surface Methodology ◽

Response Surface ◽

Edible Oil ◽

Ultrasound Assisted Extraction ◽

Assisted Extraction ◽

Rsm Optimization ◽

Processing Wastes ◽

Tomato Processing ◽

Ultrasound Assisted

Download Full-text

Ultrasound-assisted extraction of bioactive alkaloids from Phellodendri amurensis cortex using deep eutectic solvent aqueous solutions

New Journal of Chemistry ◽

10.1039/d0nj00877j ◽

2020 ◽

Vol 44 (22) ◽

pp. 9172-9178

Author(s):

Yuanbin Li ◽

Zuchen Pan ◽

Binshen Wang ◽

Wen Yu ◽

Siwei Song ◽

...

Keyword(s):

Citric Acid ◽

Aqueous Solutions ◽

Deep Eutectic Solvent ◽

Green Solvents ◽

Ultrasound Assisted Extraction ◽

Assisted Extraction ◽

Ultrasound Assisted

ChCl/citric acid-based DESs are demonstrated to be effective green solvents for the ultrasound-assisted extraction of bioactive alkaloids from herbs.

Download Full-text

Innovative Extraction Techniques for the Optimum Extraction of Phenolic Compounds from Peanut Meal and Evaluation of Their Biological Activities

Advances in Nutrition & Food Science ◽

10.33140/anfs.04.02.2 ◽

2019 ◽

Vol 4 (2) ◽

Keyword(s):

Phenolic Compounds ◽

Carcinoma Cell ◽

Biological Activities ◽

Peanut Meal ◽

Ultrasound Assisted Extraction ◽

Carcinoma Cell Lines ◽

Assisted Extraction ◽

Phenolic Extract ◽

Ultrasound Assisted ◽

Water Ratio

There is a worldwide demand for phenolic compounds (PC) because they exhibit several biological activities. This work aimed at extracting phenolic compounds from peanut meal. The methods of extraction were mainly: conventional solvent extraction (traditional methods) and ultrasound assisted extraction (recent methods) and comparing their results. Peanut meal (PM) was prepared by defatting with n-hexane, and then extracted by the two previous methods. First, the conventional solvents used were 80% methanol, ethanol, acetone, isopropanol, and distilled water. Then studied Different parameters such as meal: water ratio, also the effect of temperature and the pH on the extraction process. Second, ultrasonic assisted extractions (USAE), the parameters investigated were temperature, time and speed of sonication. Finally, all the extracts were analyzed by HPLC for their phenolic contents. Results indicated that the highest extracted PC achieved by solvents was in distilled water where 1:100, Meal: Water ratio which extracted 40 mg PC / g PM at 30& 35°C. Highest extracted PC was achieved by alkaline medium at pH 12 more than acidic and neutral medium. While (USAE) at speed 8 ultrasonication and temperature 30ᵒC, extracted 49.2mg PC /g PM. Sothe ultrasound assisted extraction exhibited great influence on the extraction of phenolic compounds from peanut meal. The ultrasonic peanut extract was examined for its antioxidant, antimicrobial and anticarcinogenic activities. The antioxidant activity of PM phenolic extract prepared by ultrasonic technique, was measured by, β-carotene, and DPPH methods, and reducing antioxidant power. Results revealed values: 84.57, 57.72 and 5960 respectively. The PM extract showed different levels of antimicrobial activity against the pathogenic bacteria used. As for the anticarcinogenic effect PM phenolic extract most effective on inhibiting colon carcinoma and lung carcinoma cell lines with IC50 = 20.7 and 20.8 µ/ml., respectively. This was followed by intestinal carcinoma and liver carcinoma cell lines with IC50= 39.6 and 40.2µ/ml.

Download Full-text