The Impact of Nontuberculous Myobacteria on Management of Presumed Pulmonary Tuberculosis

Infection ◽  
2001 ◽  
Vol 29 (2) ◽  
pp. 59-63 ◽  
Author(s):  
R. van Crevel ◽  
W.C.M. de Lange ◽  
N.A. Vanderpuye ◽  
D. van Soolingen ◽  
J.A.A. Hoogkamp-Korstanje ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
The Impact

scholarly journals Evaluation of the effect of the capitation compensation mechanism among pulmonary tuberculosis patients with a full period of treatment

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Xing-Yu Hu ◽  
Guang-Ying Gao
Keyword(s):  
Pulmonary Tuberculosis ◽  
Patient Compliance ◽  
Quantitative Data ◽  
Financial Burden ◽  
Descriptive Analysis ◽  
Compensation Mechanism ◽  
Medication Costs ◽  
Implementation Time ◽  
Full Period ◽  
The Impact

Abstract Background PTB is an infectious disease, which not only seriously affects people’s health, but also causes a heavier disease economic burden on patients. At present, reform of the medical insurance payment can be an effective method to control medical expenses. Therefore, our study is to explore the compensation mechanism for pulmonary tuberculosis (PTB) patients with a full period of treatment, to alleviate the financial burden of PTB patients and provide a reference and basis for the reform of PTB payment methods in other regions and countries. Methods The quantitative data of PTB patients was collected from the first half of 2015 to the first half of 2018 in Dehui Tuberculosis Hospital in Jilin Province, and medical records of PTB patients registered in the first half of 2018 (n = 100) from the hospital was randomly selected. Descriptive analysis of these quantitative data summarized the number, cost, medication and compliance. Semi-structured in depth interviews with policymakers and physicians were conducted to understand the impact of interventions and its causes. Results After implementation of the compensation mechanism, the number of PTB patient visits in 2018 was increased by 14.2%, average medical costs for outpatients and inpatients were significantly reduced by 31.8% and 47.0%, respectively, and the auxiliary medication costs was reduced by 36.5%. Moreover, the hospital carried out standardized management of tuberculosis, and the patient compliance was very high, reaching almost 90%. Conclusions The capitation compensation mechanism with a full period of treatment was a suitable payment method for PTB, and it is worthy of promotion and experimentation. In addition, the model improved patient compliance and reduced the possibility of drug-resistant PTB. However, due to the short implementation time of the model in the pilot areas, the effect remains to be further observed and demonstrated.

Impact of diabetes on clinical presentation and treatment outcome of pulmonary tuberculosis in Beijing

2014 ◽  
Vol 143 (1) ◽  
pp. 150-156 ◽  
Author(s):  
C. HONGGUANG ◽  
L. MIN ◽  
J. SHIWEN ◽  
G. FANGHUI ◽  
H. SHAOPING ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Treatment Outcome ◽  
Pulmonary Tuberculosis ◽  
Odds Ratio ◽  
Clinical Presentation ◽  
Underlying Mechanism ◽  
Urban Setting ◽  
Sputum Smear ◽  
Positive Sputum Smear ◽  
The Impact

SUMMARYDiabetes mellitus (DM) is currently known to be one of the risk factors for pulmonary tuberculosis (PTB) and the proportion of DM in PTB is rising along with the increased prevalence of DM in countries with high PTB burden. This study was designed to explore the impact of DM on clinical presentation and treatment outcome of PTB in China. In an urban setting in Beijing, 1126 PTB patients, 30·6% with positive sputum smear, registered in two PTB dispensaries from January 2010 to December 2011 were screened for DM and were followed up prospectively during PTB treatment. DM was observed in 16·2% of patients with PTB. PTB with DM appeared to be associated with older age and a higher proportion of re-treatment. On presentation, DM was associated with more severe PTB signs with higher proportions of smear positivity [odds ratio (OR) 2·533, 95% confidence interval (CI) 1·779–3·606], cavity (OR 2·253, 95% CI 1·549–3·276) and more symptoms (OR 1·779, 95% CI 1·176–2·690). DM was also associated with non-TB deaths (OR 5·580, 95% CI 2·182–14·270, P < 0·001) and treatment failure (OR 6·696, 95% CI 2·019–22·200, P = 0·002). In Beijing, the findings of this study underlined the need to perform early bi-directional screening programmes and explore the underlying mechanism for different treatment outcomes for PTB with DM.

The Impact of Age on the Demographic, Clinical, Radiographic Characteristics and Treatment Outcomes of Pulmonary Tuberculosis Patients in Taiwan

Infection ◽  
2008 ◽  
Vol 36 (4) ◽  
pp. 335-340 ◽  
Author(s):  
C.-S. Wang ◽  
H.-C. Chen ◽  
C.-J. Yang ◽  
W.-Y. Wang ◽  
I.-W. Chong ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Treatment Outcomes ◽  
Tuberculosis Patients ◽  
The Impact

scholarly journals Evaluation of the impact that the changes in tuberculosis treatment implemented in Brazil in 2009 have had on disease control in the country

2017 ◽  
Vol 43 (6) ◽  
pp. 437-444 ◽  
Author(s):  
Marcelo Fouad Rabahi ◽  
José Laerte Rodrigues da Silva Júnior ◽  
Marcus Barreto Conde
Keyword(s):  
Time Series ◽  
Pulmonary Tuberculosis ◽  
Time Series Analysis ◽  
Interrupted Time Series ◽  
Tuberculosis Treatment ◽  
Interrupted Time Series Analysis ◽  
Mdr Tb ◽  
Treatment Abandonment ◽  
Cure Rates ◽  
The Impact

ABSTRACT Objective: To analyze the impact that the 2009 changes in tuberculosis treatment in Brazil had on the rates of cure, tuberculosis recurrence, mortality, treatment abandonment, and multidrug-resistant tuberculosis (MDR-TB). Methods: An ordinary least squares regression model was used in order to perform an interrupted time series analysis of secondary data collected from the Brazilian Tuberculosis Case Registry Database for the period between January of 2003 and December of 2014. Results: The 2009 changes in tuberculosis treatment in Brazil were found to have no association with reductions in the total number of cases (β = 2.17; 95% CI: −3.80 to 8.14; p = 0.47) and in the number of new cases (β = −0.97; 95% CI: −5.89 to 3.94; p = 0.70), as well as having no association with treatment abandonment rates (β = 0.40; 95% CI: −1.12 to 1.93; p = 0.60). The changes in tuberculosis treatment also showed a trend toward an association with decreased cure rates (β = −4.14; 95% CI: −8.63 to 0.34; p = 0.07), as well as an association with increased mortality from pulmonary tuberculosis (β = 0.77; 95% CI: 0.16 to 1.38; p = 0.01). Although there was a significant increase in MDR-TB before and after the changes (p < 0.0001), there was no association between the intervention (i.e., the changes in tuberculosis treatment) and the increase in MDR-TB cases. Conclusions: The changes in tuberculosis treatment were unable to contain the decrease in cure rates, the increase in treatment abandonment rates, and the increase in MDR-TB rates, being associated with increased mortality from pulmonary tuberculosis during the study period. Keywords: Tuberculosis, pulmonary/epidemiology; Tuberculosis, pulmonary/drug therapy; Tuberculosis, pulmonary/mortality; Interrupted time series analysis; Drug resistance, multiple; Drug compounding.

scholarly journals Validation of the St George’s respiratory questionnaire Vietnamese Version in new pulmonary tuberculosis patients

2020 ◽  
Author(s):  
Han Nguyen ◽  
Khan Mai Xuan ◽  
Tuan Nguyen Chi ◽  
Tung Nguyen Thanh ◽  
Quyet Do
Keyword(s):  
Pulmonary Tuberculosis ◽  
Military Hospital ◽  
Ethical Review ◽  
Cronbach’S Alpha ◽  
Tuberculosis Patients ◽  
Cronbach's Alpha ◽  
Case Series Study ◽  
St George's Respiratory Questionnaire ◽  
The Impact

Abstract Background: According to the Global Tuberculosis Report 2019, Vietnam is one of the 20 countries with the highest TB prevalence in the world. Pulmonary tuberculosis has a significant effect on lung functions, causing many obstacles in daily activities and affects the quality of patient’s lives.Methods: The case-series study conducted on 43 newly-diagnosed pulmonary tuberculosis patients at the Department of Tuberculosis - Military Hospital 103 within 4 months. The aims of the current study were to evaluate the validity of the Vietnamese version of the St. George's Respiratory Questionnaire and to investigate the relationship between SGRQ scores and the clinical and subclinical symptoms in new pulmonary tuberculosis patients.Results: The results indicate that Vietnamese version of the SGRQ has high reliability with Cronbach's alpha of Total score was 0.9451, Cronbach's alpha of all domains was above 0.6, of which the Symptom domain was 0.6635, the Impact domain was 0.9069, the Activity domain was 0.9121. The study also showed that SGRQ score was proportional to the aggregate size of all cavities on chest X-ray (r = 0.3772) and inversely proportional to BMI (r = -0.2843), MGIT days to positivity (r = -0.1635).Conclusions: The Vietnamese version of the SGRQ is a highly reliable and valuable questionnaire in assessing symptoms and life effects in new PTB patients. We recommend it as symptom measurement and quality of life evaluation in patients with new PTB in future studies.Trial registration: The study protocol was approved by the Ethical Review Board Committee of Vietnam Military Medical University (IRB No. 250/2020/QĐ-HVQY) and by the local ethics committee of Military hospital 103. All participants had provided written informed consents for this study.

scholarly journals Effect of reserved line’s anti-tuberculosis medicines to antiinflammatory cytokine production for patients with pulmonary tuberculosis

2010 ◽  
Vol 9 (5) ◽  
pp. 64-71 ◽  
Author(s):  
T. Ye. Kononova ◽  
O. I. Urazova ◽  
V. A. Serebryakova ◽  
V. V. Novitsky ◽  
O. A. Vasiliyeva ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Cytokine Production ◽  
Transforming Growth Factor ◽  
Specific Treatment ◽  
Pathological Process ◽  
Aminosalicylic Acid ◽  
Blood Leukocytes ◽  
Antituberculosis Therapy ◽  
Negative Effect ◽  
The Impact

The results of research show the impact of ofloxacin, para-aminosalicylic acid (PASA) and capreomycin in conjunction with the BCG vaccine strain to the cytokine-production ability of mononuclear peripheral blood leukocytes for patients with infiltrative pulmonary tuberculosis prior to specific antituberculosis therapy. The results show that ofloxacin has inducing effect on the secretion of interleukin (IL) 4 and transforming growth factor (TGF) β; PASA and capreomycin have such effect for the products of IL10 and TGFβ. This influence has a negative effect during the active development of the pathological process and during specific treatment.

scholarly journals Pulmonary tuberculosis incidence, trends and predictions in Monastir, Tunisia (2000-2030)

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
C Ben Nasrallah ◽  
I Zemni ◽  
M Kacem ◽  
W Dhouib ◽  
R Bannour ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Incidence Rate ◽  
Program Effectiveness ◽  
Control Strategies ◽  
Control Program ◽  
Crude Incidence ◽  
Age Cohorts ◽  
Tb Control ◽  
Incidence Trends ◽  
The Impact

Abstract Background Tuberculosis (TB) continues to be one of the infectious diseases with the highest morbidity worldwide. The lung is the most commonly involved organ, but lesions can occur in other body systems. This study aimed to describe incidence and trends of pulmonary tuberculosis (PTB) over a period of 18 years in Monastir and to estimate predictions for 2030. Methods We carried out an observational study from 2000 to 2017. Data were collected by the regional direction of primary health care. Incidence was estimated by the crude incidence rate (CIR) and the age standardized rate (ASR). Poisson regression model was used to calculate the slope 'b' in order to describe trends and was performed to estimate incidence projection for 2030. Data were verified and analyzed using IBM SPSS Statistics version 22.0 software. Results A total of 997 patients were recorded with 486 cases of PTB (48.95%). Sex ratio was 2.85. The median age was 40.5 [IQR 28-56] years old. PTB ASR was 5.71/100,000 inhabitants (inh). CIR was the highest among the eldest cohort aged more than 60 years (12.65/100,000 inh) and the lowest among youth aged less than 19 years (1.01/100,000 inh). We established a negative trend of PTB over 18 years (b= -0.032; p &lt; 10-4) in all age cohorts. PTB would be decreasing by 2030 with an estimate incidence rate of 1.83/100,000 inh. Conclusions The decline of PTB may be a sign of TB control program effectiveness in Monastir. Thus, the challenges for the future are to maintain PTB towards decreasing. Key messages Our study highlighted the impact of TB control strategies in Tunisia. Our findings play a key role in estimating whether the WHO’s End TB strategy targets can be achieved by 2030.

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