Morphological and in vitro investigation of core–shell nanostructures of carvedilol using quality by design

2015 ◽  
Vol 45 (6) ◽  
pp. 561-578 ◽  
Author(s):  
Jerome K. George ◽  
Sandeep Kumar Singh ◽  
Priya Ranjan Prasad Verma
Keyword(s):  
Quality By Design ◽  
Core Shell ◽  
Shell Nanostructures ◽  
In Vitro Investigation

In vitro hyperthermia with improved colloidal stability and enhanced SAR of magnetic core/shell nanostructures

2016 ◽  
Vol 59 ◽  
pp. 702-709 ◽  
Author(s):  
R.M. Patil ◽  
N.D. Thorat ◽  
P.B. Shete ◽  
S.V. Otari ◽  
B.M. Tiwale ◽  
...  
Keyword(s):  
Colloidal Stability ◽  
Magnetic Core ◽  
Core Shell ◽  
Shell Nanostructures

scholarly journals Efficacy of Amphiphilic Core-Shell Nanostructures Encapsulating Gentamicin in an In Vitro Salmonella and Listeria Intracellular Infection Model

2010 ◽  
Vol 54 (8) ◽  
pp. 3524-3526 ◽  
Author(s):  
A. Ranjan ◽  
N. Pothayee ◽  
T. P. Vadala ◽  
M. N. Seleem ◽  
E. Restis ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Confocal Microscopy ◽  
Fluid Phase ◽  
Infection Model ◽  
Core Shell ◽  
Intracellular Pathogens ◽  
Shell Nanostructures ◽  
Fluid Phase Endocytosis ◽  
Effective Transport

ABSTRACT Core-shell nanostructures with nonionic amphiphilic shells and ionic cores encapsulating gentamicin were designed for therapy against intracellular pathogens, including Salmonella and Listeria. Flow cytometry and confocal microscopy showed that their uptake into J774A.1 macrophages proceeded mainly by fluid-phase endocytosis and clathrin-mediated pathways. The nanostructures were nontoxic in vitro at doses of 50 to 250 μg/ml, and they significantly reduced the amounts of intracellular Salmonella (0.53 log) and Listeria (3.16 log), thereby suggesting effective transport into the cells.

scholarly journals In Vitro Trafficking and Efficacy of Core-Shell Nanostructures for Treating Intracellular Salmonella Infections

2009 ◽  
Vol 53 (9) ◽  
pp. 3985-3988 ◽  
Author(s):  
A. Ranjan ◽  
N. Pothayee ◽  
M. N. Seleem ◽  
N. Sriranganathan ◽  
R. Kasimanickam ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Confocal Microscopy ◽  
Surface Property ◽  
Core Shell ◽  
Bacterial Clearance ◽  
Bacterial Counts ◽  
Shell Nanostructures ◽  
Salmonella Infections

ABSTRACT Nanostructures encapsulating gentamicin and having either amphiphilic (N1) or hydrophilic (N2) surfaces were designed. Flow cytometry and confocal microscopy studies demonstrated a higher rate of uptake for amphiphilic surfaces. A majority of N1 were localized in the cytoplasm, whereas N2 colocalized with the endosomes/lysosomes. Colocalization was not observed between nanostructures and intracellular Salmonella bacteria. However, significant in vitro reductions in bacterial counts (0.44 log10) were observed after incubation with N1, suggesting that the surface property of the nanostructure influences intracellular bacterial clearance.

Core–shell hydroxyapatite/Mg nanostructures: surfactant free facile synthesis, characterization and their in vitro cell viability studies against leukaemia cancer cells (K562)

RSC Advances ◽  
2015 ◽  
Vol 5 (60) ◽  
pp. 48705-48711 ◽  
Author(s):  
M. Manoj ◽  
D. Mangalaraj ◽  
N. Ponpandian ◽  
C. Viswanathan
Keyword(s):  
Cell Viability ◽  
Cancer Cells ◽  
Chelating Agent ◽  
Cost Effective ◽  
Precipitation Method ◽  
Core Shell ◽  
Facile Synthesis ◽  
Effective Precipitation ◽  
Shell Nanostructures

Hydroxyapatite/magnesium core–shell nanostructures were synthesized by a simple and cost effective precipitation method without a surfactant or ligand/chelating agent.

In vitro investigation of Varizella zoster virus as an oncolytic virus in glioblastoma therapy

2008 ◽  
Vol 35 (S 01) ◽  
Author(s):  
H Leske ◽  
A Baiker ◽  
C Schichor ◽  
J.C Tonn ◽  
R Goldbrunner ◽  
...  
Keyword(s):  
Oncolytic Virus ◽  
In Vitro Investigation ◽  
Varizella Zoster Virus

An In Vitro Investigation of Synergy or Antagonism between Antimicrobial Combinations against Isolates from Bacterial Keratitis

2010 ◽  
Vol 51 (8) ◽  
pp. 4151 ◽  
Author(s):  
Henri Sueke ◽  
Stephen B. Kaye ◽  
Timothy Neal ◽  
Amanda Hall ◽  
Stephen Tuft ◽  
...  
Keyword(s):  
Bacterial Keratitis ◽  
In Vitro Investigation ◽  
Antimicrobial Combinations
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