scholarly journals Cerebrospinal-fluid-derived Immunoglobulin G of Different Multiple Sclerosis Patients Shares Mutated Sequences in Complementarity Determining Regions

2013 ◽  
Vol 12 (12) ◽  
pp. 3924-3934 ◽  
Author(s):  
Vaibhav Singh ◽  
Marcel P. Stoop ◽  
Christoph Stingl ◽  
Ronald L. Luitwieler ◽  
Lennard J. Dekker ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Immunoglobulin G ◽  
Complementarity Determining Regions ◽  
Multiple Sclerosis Patients

Abnormal galactosylation of immunoglobulin G in cerebrospinal fluid of multiple sclerosis patients

2016 ◽  
Vol 22 (14) ◽  
pp. 1794-1803 ◽  
Author(s):  
Yann Decker ◽  
Robert Schomburg ◽  
Eszter Németh ◽  
Artem Vitkin ◽  
Mathias Fousse ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Immunoglobulin G ◽  
Viral Meningitis ◽  
Brain Inflammation ◽  
Age And Gender ◽  
History Of ◽  
And Gender ◽  
Multiple Sclerosis Patients ◽  
And Control

Background: Glycosylation alterations have been associated with the development of several human diseases and their animal models, including multiple sclerosis. Objectives: We aimed to determine whether immunoglobulin G galactosylation might be changed in multiple sclerosis. Methods: Immunoglobulin G was isolated from serum and cerebrospinal fluid of patients with multiple sclerosis or viral meningitis and control patients without history of inflammatory or autoimmune disease. A lectin-based assay was used to investigate potential galactosylation modifications of immunoglobulin G. Results and conclusion: Galactosylation of immunoglobulin G isolated from cerebrospinal fluid of control patients was found to be age- and gender-dependent. In addition, immunoglobulin G galactosylation was significantly altered in cerebrospinal fluid but not in serum of multiple sclerosis patients. Furthermore, this modification was correlated with an active progression of multiple sclerosis. Finally, the loss of galactosyl moieties was not simply associated with inflammation as no such change was detected in viral meningitis patients characterized by brain inflammation.

scholarly journals Complement Receptor 2 is increased in cerebrospinal fluid of multiple sclerosis patients and regulates C3 function

2016 ◽  
Vol 166-167 ◽  
pp. 89-95 ◽  
Author(s):  
Rickard P.F. Lindblom ◽  
Shahin Aeinehband ◽  
Mikael Ström ◽  
Faiez Al Nimer ◽  
Kerstin Sandholm ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Complement Receptor ◽  
Complement Receptor 2 ◽  
Multiple Sclerosis Patients

scholarly journals Genetic and Infectious Profiles Influence Cerebrospinal Fluid IgG Abnormality in Japanese Multiple Sclerosis Patients

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e95367 ◽  
Author(s):  
Satoshi Yoshimura ◽  
Noriko Isobe ◽  
Takuya Matsushita ◽  
Katsuhisa Masaki ◽  
Shinya Sato ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Multiple Sclerosis Patients
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