scholarly journals Genetic and Infectious Profiles Influence Cerebrospinal Fluid IgG Abnormality in Japanese Multiple Sclerosis Patients

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e95367 ◽  
Author(s):  
Satoshi Yoshimura ◽  
Noriko Isobe ◽  
Takuya Matsushita ◽  
Katsuhisa Masaki ◽  
Shinya Sato ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Multiple Sclerosis Patients

scholarly journals Complement Receptor 2 is increased in cerebrospinal fluid of multiple sclerosis patients and regulates C3 function

2016 ◽  
Vol 166-167 ◽  
pp. 89-95 ◽  
Author(s):  
Rickard P.F. Lindblom ◽  
Shahin Aeinehband ◽  
Mikael Ström ◽  
Faiez Al Nimer ◽  
Kerstin Sandholm ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Complement Receptor ◽  
Complement Receptor 2 ◽  
Multiple Sclerosis Patients

scholarly journals Cerebrospinal-fluid-derived Immunoglobulin G of Different Multiple Sclerosis Patients Shares Mutated Sequences in Complementarity Determining Regions

2013 ◽  
Vol 12 (12) ◽  
pp. 3924-3934 ◽  
Author(s):  
Vaibhav Singh ◽  
Marcel P. Stoop ◽  
Christoph Stingl ◽  
Ronald L. Luitwieler ◽  
Lennard J. Dekker ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Immunoglobulin G ◽  
Complementarity Determining Regions ◽  
Multiple Sclerosis Patients

scholarly journals Epitope Analysis of Cerebrospinal Fluid IgG in Japanese Multiple Sclerosis Patients Using Phage Display Method

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Juichi Fujimori ◽  
Ichiro Nakashima ◽  
Kazuo Fujihara ◽  
Tatsuro Misu ◽  
Shigeru Sato ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Phage Display ◽  
Amino Acid Sequences ◽  
Barr Virus ◽  
Common Motif ◽  
Bystander Response ◽  
Epstein Barr ◽  
Simplex Virus ◽  
Multiple Sclerosis Patients

To investigate the antigen recognized by cerebrospinal fluid (CSF) high affinity IgG in patients with multiple sclerosis (MS), the phage display method was applied to the CSF from 15 MS and 10 control patients. Peptide sequences recognized by MS and control CSF IgG were individual specific, and no common motif was found. Peptide sequences frequently showed homology to various kinds of amino acid sequences of ubiquitous viruses such as epstein barr virus (EBV) and herpes simplex virus (HSV), although the frequency was not specific to MS patients. MS CSF IgG may recognize various types of ubiquitous viral antigen and may be increased by a bystander response.

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