The Causal Association Between Occupational, Environmental, and Lifestyle Factors and Reproductive Cancer Risk

2020 ◽  
Vol 6 (4) ◽  
pp. 149-160
Author(s):  
Hari Shankar ◽  
Shukla Saluja ◽  
Monica Rawat ◽  
Gyanendra Singh ◽  
Mohammad Tarique ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Lifestyle Factors ◽  
Causal Association

scholarly journals Women’s intentions to engage in risk-reducing behaviours after receiving personal ovarian cancer risk information: an experimental survey study

2019 ◽  
Author(s):  
Ailish Gallagher ◽  
Jo Waller ◽  
Ranjit Manchanda ◽  
Ian Jacobs ◽  
Saskia Sanderson
Keyword(s):  
Ovarian Cancer ◽  
Cancer Risk ◽  
Risk Stratification ◽  
Perceived Risk ◽  
Lifestyle Factors ◽  
Cancer Risk Assessment ◽  
Survey Study ◽  
Ovarian Cancer Risk ◽  
Risk Reducing ◽  
Experimental Survey

Risk stratification using genetic and/or other types of information could identify women at increased ovarian cancer risk. The aim of this study was to examine women’s potential reactions to ovarian cancer risk stratification. 1,017 women aged 45-75 years took part in an online experimental survey. Women were randomly assigned to one of three experimental conditions describing hypothetical personal results from ovarian cancer risk stratification, and asked to imagine they had received one of three results: (a) 5% risk due to SNPs and lifestyle factors; (b) 10% risk due to SNPs and lifestyle factors; (c) 10% risk due to a rare mutation in BRCA2. 83% of women indicated interest in having ovarian cancer risk assessment. After receiving their hypothetical risk estimates, 29% of women stated they would have risk-reducing surgery. Choosing risk-reducing surgery over other behavioural responses was associated with having higher surgery self-efficacy and perceived response-efficacy, but not with perceptions of disease threat, i.e. perceived risk or severity, or with experimental condition. A substantial proportion of women age 45-75 years may be open to the idea of surgery to reduce risk of ovarian cancer, even if their absolute lifetime risk is only increased to as little as 5 or 10%.

scholarly journals Modifiable Lifestyle Factors: Opportunities for (Hereditary) Breast Cancer Prevention - a Narrative Review

Breast Care ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. 108-113 ◽  
Author(s):  
Jacqueline Lammert ◽  
Sabine Grill ◽  
Marion Kiechle
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Cancer Prevention ◽  
Healthy Lifestyle ◽  
Absolute Risk ◽  
Lifestyle Factors ◽  
Breast Cancer Prevention ◽  
The Impact

Increasing rates of obesity, lack of physical activity, sedentary behavior, and frequent alcohol consumption are major lifestyle-related risk factors for breast cancer. In fact, it has been estimated that about one-third of breast cancer cases are attributable to factors women can change. Most research has focused on examining the impact of one single exposure on breast cancer risk while adjusting for other risk modifiers. Capitalizing on big data, major efforts have been made to evaluate the combined impact of well-established lifestyle factors on overall breast cancer risk. At the individual level, data indicate that even simple behavior modifications could have a considerable impact on breast cancer prevention. Moreover, there is emerging new evidence that adopting a healthy lifestyle may be particularly relevant for women with hereditary susceptibility to breast cancer. On the absolute risk scale, studies suggest that the presence of certain risk factors, such as excessive body weight, had a substantially higher impact on breast cancer risk if women had a hereditary predisposition to cancer. The existing body of knowledge gives the medical professionals guidance as to which factors to focus on when counseling patients. However, well-designed randomized controlled trials utilizing objective methods are crucial to providing concrete recommendations.

Abstract 5269: Body mass index may not have causal association with thyroid cancer risk: A Mendelian randomization study

2018 ◽  
Author(s):  
Jeongseon Kim ◽  
Soo Ji Lee ◽  
Quy N. Nguyen ◽  
Jeonghee Lee ◽  
Eun Kyung Lee ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Thyroid Cancer ◽  
Cancer Risk ◽  
Body Mass ◽  
Mendelian Randomization ◽  
Causal Association ◽  
Thyroid Cancer Risk

Abstract B72: Does prostate cancer risk vary by race after accounting for lifestyle factors in the Health Professionals Follow-up Study

2017 ◽  
Author(s):  
Nadine M. Hamieh ◽  
Sarah Markt ◽  
Sam Peisch ◽  
Edward Giovannucci ◽  
Kathryn Wilson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Health Professionals ◽  
Prostate Cancer Risk ◽  
Lifestyle Factors ◽  
Follow Up Study

scholarly journals IGF1 CA repeat polymorphisms, lifestyle factors and breast cancer risk in the Long Island Breast Cancer Study Project

2005 ◽  
Vol 27 (4) ◽  
pp. 758-765 ◽  
Author(s):  
Rebecca J. Cleveland ◽  
Marilie D. Gammon ◽  
Sharon N. Edmiston ◽  
Susan L. Teitelbaum ◽  
Julie A. Britton ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Long Island ◽  
Lifestyle Factors ◽  
Ca Repeat ◽  
Cancer Study ◽  
Breast Cancer Study

scholarly journals Body Mass Index and Cancer Risk: The Evidence for Causal Association~!2009-04-22~!2009-06-16~!2010-07-13~!

2010 ◽  
Vol 2 (2) ◽  
pp. 12-22 ◽  
Author(s):  
Andrew G. Renehan ◽  
Matthias Egger ◽  
Marcel Zwahlen
Keyword(s):  
Body Mass Index ◽  
Cancer Risk ◽  
Body Mass ◽  
Causal Association
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