This chapter assesses transdisciplinarity as an epistemological and methodological approach to research and teaching in the emerging field of global studies. It posits that the world’s most pressing problems in the areas of migration, health, and intersectional identities, to name a few, are unlikely to be addressed convincingly by inquiries rooted exclusively in singular social science disciplines. At the same time, transdisciplinarity is understood as a means to complement disciplinary research, not to dispense with it. By foregrounding global–local dynamics and their effects across scales, global studies can draw from a wealth of approaches and experiences in interdisciplinary scholarship without becoming entangled in protracted epistemological battles over scholarly turf. This chapter then provides examples of transdisciplinary research in global studies and closes by stressing the importance of disciplinary methodological innovations as building blocks for multimodal designs and arguing for methodological rigor in global studies, whether transdisciplinary or not.