The relationship between estimated glomerular filtration rate and urine m/creatinine ratio and parathyroid hormone in elderly Koreans

HORMONES ◽  
2019 ◽  
Vol 18 (4) ◽  
pp. 485-494
Author(s):  
Jun Ho Lee ◽  
Sang Muk Park ◽  
Mi Young Gi ◽  
Ju Ae Cha ◽  
Ae Eun Moon ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Parathyroid Hormone ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Creatinine Ratio ◽  
Elderly Koreans ◽  
The Relationship

Abstract 6277: Predictive Value of Estimated Glomerular Filtration Rate for Cardiovascular Events: The Treating to New Targets Study

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
James Shepherd ◽  
Chuan-Chuan Wun ◽  
Daniel J Wilson ◽  
Andrea L Zuckerman
Keyword(s):  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Cardiovascular Events ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Lipid Lowering ◽  
Final Visit ◽  
The Relationship ◽  
Dose Dependent

We previously demonstrated a dose-dependent improvement in renal function and reduction in cardiovascular risk in TNT with intensive lipid lowering with atorvastatin (ATV) 80 mg vs 10 mg. This post hoc analysis examines the relationship between the observed improvement in estimated glomerular filtration rate (eGFR) and reduction of major cardiovascular events (MCVE). After 8 weeks open-label therapy with ATV 10 mg, 10,001 patients with CHD were randomized to double-blind therapy with either ATV 10 or 80 mg. Patients were followed for a median of 4.9 years for the occurrence of MCVEs (CHD death, nonfatal MI, and stroke). The relationship between change from baseline eGFR (using the MDRD equation) at the final visit prior to a MCVE and the risk of MCVE was assessed using a Cox proportional hazards model adjusting for baseline eGFR and other baseline characteristics. Of 9656 patients with complete renal data, 156 had a MCVE before follow-up eGFR assessment and were excluded. In the remaining 9500 patients, mean baseline eGFR was 65.3 mL/min/1.73 m 2 and mean change from baseline was 4.3 mL/min/1.73 m 2 . This represented a reduction in the risk of MCVE of 2.7% per mL increase in eGFR (HR 0.973, 95% CI 0.967– 0.980, P <0.0001). This association remained significant in patients with eGFR <60 and those with eGFR ≥60 mL/min/1.73 m 2 at baseline, with no significant interaction between eGFR change and baseline renal status ( P =0.98). A 5 mL/min on-treatment improvement in eGFR was associated with a 12.6% reduction in MCVE, while a 5 mL/min reduction was associated with a 14.4% increase in MCVE. Mean change from baseline eGFR was 3.5 mL/min/1.73 m 2 with ATV 10 mg and 5.2 mL/min/1.73 m 2 with ATV 80 mg, representing significant 9.3% and 12.4% reductions in risk, respectively. Analysis of interaction between treatment and eGFR change for prediction of MCVE demonstrated a stronger association between eGFR change and MCVE in the ATV 80 mg treatment group ( P =0.011). Improvement in eGFR was highly associated with a reduction in MCVE, irrespective of baseline renal function. This relationship was dose dependent. Improvement in eGFR may be a biomarker for the response to atorvastatin, and for the stabilization of atherosclerotic cardiovascular disease.

scholarly journals Relationship between Body Mass Index (BMI) and Glomerulus Filtration Rate Estimation in Overweight Students at the Health Analyst Department of Pontianak Health Polytechnic

2021 ◽  
Vol 2 (1) ◽  
pp. 27-33
Author(s):  
Slamet
Keyword(s):  
Body Mass Index ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Body Mass ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
The Body ◽  
P Value ◽  
Fat Deposits ◽  
The Relationship

Obesity occurs due to excessive fat deposits in the body, one of which is a poor diet. The relationship between overweight and chronic kidney disease (CKD) is mediated through several mechanisms of adiponectin, leptin, and resistin, the development of inflammation, oxidative stress, abnormal lipid metabolism, and activation of the renin-angiotensin-aldosterone system. The purpose of this study was to determine the relationship between body mass index and estimated glomerular filtration rate in overweight students at the Health Analyst Department of Pontianak Health Polytechnic. The research design used was cross-sectional. This research was conducted on May 14-18, 2018. The population is a student health analyst. With the criteria for students from the 2015 and 2016 batches who are still active, BMI 23-29.9 Kg/m² and aged 18 to 22 years, totaling 37 respondents. The sampling technique used is total sampling. Performed include measurements of BMI, serum creatinine Jaffe method, fixed time and ELFG Cokroft-Gault formula. The results obtained using the Kendall's tau test showed that the p value (0.906) was greater than (0.05) meaning that there was no relationship between body mass index and estimated glomerular filtration rate in overweight students at the Health Analyst Department of Pontianak Health Polytechnic.

Relationship between estimated glomerular filtration rate and biological half-life of 131I

2013 ◽  
Vol 52 (05) ◽  
pp. 164-169
Author(s):  
K. Vogel ◽  
T. Opfermann ◽  
S. Wiegand ◽  
J. Biermann ◽  
M. Busch ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Thyroid Carcinoma ◽  
Glomerular Filtration ◽  
Half Life ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Differentiated Thyroid Carcinoma ◽  
Disease Epidemiology ◽  
Biological Half Life ◽  
The Relationship

Summary Aim: This retrospective study sought to investigate the relationship between biological half-life (t 1/2 biol ) of 131I and estimated glomerular filtration rate (eGFR) in patients with thyroid carcinoma. Patients, methods: 96 patients with differentiated thyroid carcinoma (69 women, 27 men, mean age 64.0 ± 13.6 years) and diagnostic and therapeutic administration of 131I were considered. Patients with pronounced specific iodine storage were not included in the study. The eGFR was estimated according to the Chronic Kidney Disease Epidemiology Collaboration (CKDEPI) formula, the t 1/2 biol via dosimetry. Patients were subdivided in groups with normal clearance (NC) (n = 37, 38.5%), medium clearance (MC) (n = 48, 50.0%), and low clearance (LC) (n = 11, 11.5%) (eGFR _ 90; 60-89; 15-59 ml/min per 1.73 m2, respectively). The relationship between eGFR and t 1/2 biol of 131I was modeled using a power function. Results: The groups significantly differed in terms of age (NC 53.8, MC 68.6, and 78.0 years, respectively), serum creatinine levels (NC: 0.71; MC: 0.85; LC: 1.18 mg/dl), and t 1/2 biol (NC: 0.53; MC: 0.71; LC: 1.01 days). The t 1/2 biol was significantly influenced only by eGFR, and not by age, gender, or body weight. The relationship between t 1/2 biol of 131I and eGFR was described by the formula t 1/2 biol = 20.3 · eGFR−0.782. Conclusions: The calculated relationship between renal function and t 1/2 biol of 131I can be used in principle to estimate a dose reduction for patients with renal insufficiency. The model, however, gives erroneous results in individual cases and therefore a routine utilization cannot be recommended. Prospective studies are necessary, based on larger patient numbers and more accurate methods for dose rate measurement and GFR.

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