Glycerol-based liquid formulation of the epiphytic yeast Hanseniaspora guilliermondii isolate YBB3 with multiple modes of action controls postharvest Aspergillus rot in grapes

Author(s):  
Murugan Nandhini ◽  
Sankarasubramanian Harish ◽  
K. Eraivan Arutkani Aiyanathan ◽  
Dhakshinamoorthy Durgadevi ◽  
Andithevar Beaulah
Author(s):  
Ulf Ziemann

This article discusses various aspects of the pharmacology of transcranial magnetic stimulator (TMS) measures. TMS measures reflect axonal, or excitatory or inhibitory synaptic excitability in distinct interneuron circuits. TMS measures can be employed to study the effects of a drug with unknown or multiple modes of action, and hence to determine its main mode of action at the systems level of the motor cortex. TMS experiments can also study acute drug effects that may be different from chronic drug effects. TMS or repetitive TMS may induce changes in endogenous neurotransmitter or neuromodulator systems. This allows for the study of neurotransmission along defined neuronal projections in health and disease. This article describes pharmacological experiments that have characterized the physiology of TMS measures of motor cortical excitability. Pharmacological challenging of TMS measures has opened a broad window into human cortical physiology.


2015 ◽  
Vol 113 (8) ◽  
pp. 1158-1167 ◽  
Author(s):  
Yu-chi Shen ◽  
Ravi Upadhyayula ◽  
Stephanie Cevallos ◽  
Ryan J Messick ◽  
Tammy Hsia ◽  
...  

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0128376 ◽  
Author(s):  
George G. Waldbusser ◽  
Burke Hales ◽  
Chris J. Langdon ◽  
Brian A. Haley ◽  
Paul Schrader ◽  
...  

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Gero Steinberg ◽  
Martin Schuster ◽  
Sarah J. Gurr ◽  
Tina A. Schrader ◽  
Michael Schrader ◽  
...  

Cancers ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 475 ◽  
Author(s):  
Yoichi Imai ◽  
Mitsuhito Hirano ◽  
Masayuki Kobayashi ◽  
Muneyoshi Futami ◽  
Arinobu Tojo

HDACs are critical regulators of gene expression that function through histone modification. Non-histone proteins and histones are targeted by these proteins and the inhibition of HDACs results in various biological effects. Moreover, the aberrant expression and function of these proteins is thought to be related to the pathogenesis of multiple myeloma (MM) and several inhibitors have been introduced or clinically tested. Panobinostat, a pan-HDAC inhibitor, in combination with a proteasome inhibitor and dexamethasone has improved survival in relapsing/refractory MM patients. We revealed that panobinostat inhibits MM cell growth by degrading the protein PPP3CA, a catalytic subunit of calcineurin. This degradation was suggested to be mediated by suppression of the chaperone function of HSP90 due to HDAC6 inhibition. Cytotoxicity due to the epigenetic regulation of tumor-associated genes by HDAC inhibitors has also been reported. In addition, HDAC6 inhibition enhances tumor immunity and has been suggested to strengthen the cytotoxic effects of therapeutic antibodies against myeloma. Furthermore, therapeutic strategies to enhance the anti-myeloma effects of HDAC inhibitors through the addition of other agents has been intensely evaluated. Thus, the treatment of patients with MM using HDAC inhibitors is promising as these drugs exert their effects through multiple modes of action.


HortScience ◽  
2017 ◽  
Vol 52 (5) ◽  
pp. 732-735 ◽  
Author(s):  
Jawwad A. Qureshi ◽  
Barry C. Kostyk ◽  
Philip A. Stansly

Control of Asian citrus psyllid Diaphorina citri Kuwayama and citrus leafminer Phyllocnistis citrella Stainton is important to reduce the spread and severity of huanglongbing (HLB) (citrus greening) and citrus canker diseases, respectively. Insecticides are critical for the management of these pests. We therefore conducted two replicated experiments using spray treatments containing single or multiple modes of action (MoA) insecticides to reduce the incidence of these two pests in bearing citrus. Tank mixing in 47 L·ha−1 (5 gal/acre) of water with synthetic plant terpenes (Requiem 25 EC, Unknown MoA) or adjuvant petroleum oil (PureSpray Green, Unknown MoA) did not improve the effectiveness of the pyrethroid zeta-cypermethrin (Mustang Max 0.15 EC, MoA 3A) against D. citri. Its control with flupyradifurone (Sivanto 200 SL MoA 4D) and PureSpray Green in 935 L·ha−1 (100 gal/acre) water was similar to Mustang Max 0.15 EC and Requiem 25 EC, but mixtures did not provide better control than Mustang Max 0.15 EC alone. Phyllocnistis citrella was controlled only with Sivanto 200 SL and PureSpray Green and Requiem 25 EC alone. The addition of cyantraniliprole (group 28 MoA in A16971 premixed with thiamethoxam MoA 4A), pymetrozine (Fulfill 50 WDG, MoA 9B), or abamectin (Agri-Mek SC, MoA 6) did not improve and in many cases reduced the performance of thiamethoxam (Actara 25 WG, MoA 4A) against D. citri and P. citrella. These results demonstrated no advantage to single applications of multiple MoAs over the most effective active ingredients when applied alone for control of D. citri or P. citrella. Therefore, rotations of these active ingredients would be preferable to mixtures to avoid selection for resistance against multiple MoAs by any one application.


2005 ◽  
Vol 86 (2) ◽  
pp. 300-308 ◽  
Author(s):  
Gerald T. Ankley ◽  
Kathleen M. Jensen ◽  
Elizabeth J. Durhan ◽  
Elizabeth A. Makynen ◽  
Brian C. Butterworth ◽  
...  

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