Hyperuricemia and Cardiovascular Diseases in Very Elderly Patients with Coronary Artery Disease

2019 ◽  
Vol 2 (2) ◽  
pp. 173-180
Author(s):  
S. V. Topolyanskaya ◽  
O. N. Vakulenko ◽  
A. E. Semashkova ◽  
L. M. Kupina ◽  
L. I. Dvoretskiy
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cardiovascular Diseases ◽  
Elderly Patients ◽  
Very Elderly ◽  
Artery Disease

Features of diabetes mellitus in very elderly patients

2019 ◽  
Vol 1 (9) ◽  
pp. 13-19
Author(s):  
S. V. Topolyanskaya ◽  
T. M. Kolontai ◽  
O. N. Vaculenko ◽  
L. I. Dvoretski
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Elderly Patients ◽  
Very Elderly ◽  
Younger Patients ◽  
Patients With Diabetes ◽  
Artery Disease

Modern concepts about features of diabetes mellitus in very elderly patients are described in the article. Special attention to the therapeutic methods of management of very elderly patients with diabetes mellitus has been devoted. The results of diabetes mellitus study in patients with coronary artery disease older than 75 years in comparison with younger patients are presented.

Interleukin-6 in Very Elderly Patients with Coronary Artery Disease

2020 ◽  
Vol 2 (10) ◽  
pp. 1818-1824
Author(s):  
S. V. Topolyanskaya ◽  
T. A. Eliseeva ◽  
O. N. Vakulenko ◽  
L. I. Dvoretski
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Elderly Patients ◽  
Interleukin 6 ◽  
Very Elderly ◽  
Artery Disease

scholarly journals Tumor Necrosis Factor-Alpha in Very Elderly Patients with Coronary Artery Disease

2021 ◽  
Vol 12 (4) ◽  
pp. 137-144
Author(s):  
Svetlana V. Topolyanskaya ◽  
Tatyana A. Eliseeva ◽  
Irina E. Godovkina ◽  
Irina S. Vasilieva ◽  
Olga N. Vakulenko ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Tumor Necrosis Factor ◽  
Elderly Patients ◽  
Tumor Necrosis ◽  
Very Elderly ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Artery Disease ◽  
Necrosis Factor

scholarly journals Study on the correlation between Left Ventricular Hypertrophy and Coronary Artery disease in the very elderly patients with hypertension

2021 ◽  
Vol 37 (5) ◽  
Author(s):  
Jian-hua Sun ◽  
Xiao-kun Liu ◽  
Qi Zhang ◽  
Qing-hua Zhang
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Left Ventricular Hypertrophy ◽  
Elderly Patients ◽  
Coronary Stenosis ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Very Elderly ◽  
Artery Disease

Objective: To investigate the relationship between left ventricular hypertrophy (LVH) and coronary artery disease in the very elderly (over 80 years old) patients with hypertension. Methods: One hundred twenty cases of very elderly patients with hypertension admitted to our hospital from March 2018 to December 2020 were selected and divided into two groups: the LVH group and the non-LVH group, all of whom were older aged over 80 years, including 62 patients in the LVH group and 58 patients in the non-LVH group. All patients underwent cardiac color Doppler ultrasound examination, 24-hour dynamic ECG examination, and coronary angiography or coronary CTA examination. The clinical data of the two groups were analyzed statistically. Results: There were significant differences in the number of diseased vessels, degree of coronary stenosis and vascular calcification between the two groups (P<0.05). Moreover, the results of risk factors for the degree of coronary artery disease in the two groups showed that the history of diabetes, 2hPG and LVH were independent risk factors for the three-vessel disease, while the history of LVH, FPG and alcohol intake were independent risk factors for diffuse lesions, but there was no statistical difference in the correlation between them and the degree of coronary stenosis. Conclusion: LVH is an independent risk factor for coronary artery stenosis and calcification in the very elderly patients with hypertension, but there is no statistical difference in the correlation between LVH and the degree of coronary stenosis. doi: https://doi.org/10.12669/pjms.37.5.4135 How to cite this:Sun JH, Liu XK, Zhang Q, Zhang QH. Study on the correlation between Left Ventricular Hypertrophy and Coronary Artery disease in the very elderly patients with hypertension. Pak J Med Sci. 2021;37(5):---------. doi: https://doi.org/10.12669/pjms.37.5.4135 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

TUMOR NECROSIS FACTOR ALFA IN VERY ELDERLY PATIENTS WITH CORONARY ARTERY DISEASE

2021 ◽  
pp. 64-70
Author(s):  
С.В. Тополянская ◽  
Т.А. Елисеева ◽  
О.Н. Вакуленко ◽  
Л.И. Дворецкий
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Elderly Patients ◽  
Type I Collagen ◽  
Cholesterol Concentration ◽  
Control Group ◽  
Type I ◽  
Very Elderly ◽  
Tnf Α ◽  
Artery Disease

Представлены результаты исследования концентрации TNF-α, а также взаимосвязи этого цитокина с рядом патологических состояний у больных старческого возраста c ИБС по сравнению с контрольной группой больных без ИБС. Средняя концентрация TNF-α достигала 9,2±4,7 пг/мл (3,9-31,9 пг/мл) при нормальных значениях TNF-α <8,1 пг/мл. Повышение уровня TNF-α обнаружено у 54,6 % больных. У больных ИБС средняя концентрация TNF-α достигала 10±4,9 пг/мл, тогда как в группе пациентов без ИБС - 6,1±1,8 пг/мл (р=0,000001). Содержание TNF-α было выше у пациентов с ХСН (р=0,002) и гиперурикемией (р=0,000006). Была выявлена достоверная позитивная корреляция уровня TNF-α и мочевой кислоты (р<0,000001), мочевины (р=0,00004), креатинина (р=0,002) и β-Cross Laps (продуктов деградации коллагена), р=0,0001, в сыворотке крови. Обнаружена отрицательная корреляция TNF-α и холестерина ЛПВП (р=0,00005), а также лептина (р=0,01). Отмечено снижение концентрации TNF-α с возрастом (р=0,006). The results of a study of the concentration of TNF-α as well as the relationship of this cytokine with a number of pathological conditions in very elderly patients with coronary artery disease compared with the control group of patients without CAD are presented in the article. The average group concentration of TNF-α reached 9,2±4,7 pg/ml (from 3,9 to 31,9 pg/ml) with normal TNF-α values of less than 8,1 pg/ml. An increase in the level of TNF-α was detected in 54,6 % of patients. In patients with coronary artery disease the average concentration of TNF-α reached 10±4,9 pg/ml, while in the group of patients without CAD - 6,1±1,8 pg/ ml (р=0,000001). TNF-α content was higher in patients with chronic heart failure (р=0,002) and with hyperuricemia (р=0,000006). The correlation analysis revealed a significant positive correlation between the level of TNF-α and uric acid (р<0,000001), between the concentration of TNF-α and the content of β-Cross Laps (degradation products of type I collagen) (р=0,0001), as well as serum creatinine (р=0,002) and urea (p=0,00004) levels. In addition, a negative correlation was found between the values of TNF-α and high-density lipoprotein cholesterol concentration (р=0,00005), as well as leptin level (h=0,01). A decrease in the concentration of TNF-а was observed with increasing age of the patients (р=0,006).

scholarly journals Statin use associated with lower mortality in very elderly patients with peripheral arterial disease

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
A Tseng ◽  
M Girardo ◽  
D Liedl ◽  
S Bhatt ◽  
P Wennberg ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Elderly Patients ◽  
Arterial Disease ◽  
Mortality Benefit ◽  
Very Elderly ◽  
All Cause Mortality ◽  
Artery Disease ◽  
Peripheral Arterial ◽  
Statin Use

Abstract Introduction Given the potential side effects and the lack of data on its efficacy, the role of statins in the very elderly (age 75+) with peripheral arterial disease (PAD) is uncertain. Previous studies have shown significant mortality benefit in very elderly patients with coronary artery disease, but the effect in PAD has not been evaluated. Methods Very elderly patients aged 75 to 80 with at least five years of follow-up who underwent ankle-brachial index (ABI) measurement were included. PAD was defined as either low ABI &lt;0.90 or high ABI &gt;1.40. Demographic, medication use, comorbidity and mortality data was obtained using the electronic medical record. Univariate and multivariate Cox proportional hazard analyses were performed. Results In total, 4,560 very elderly subjects with PAD were included in the analysis. The median age was 77 (interquartile range 76–79) and 39% were female. 3,462 (76%) had low ABI while 1098 (24%) had high ABI. Univariate analysis showed that patients on statins were more likely to be male, have diabetes, have coronary artery disease, and have hyperlipidemia. Overall, 1,355 (30%) patients died in the five-year period. Unadjusted all-cause mortality hazard ratios for patients with low or high ABI with statin use was 0.66 (95% confidence interval [CI]: 0.57–0.75) and 0.80 (95% CI: 0.66–0.97), respectively. After adjusting for age, sex, coronary artery disease and diabetes, statin use in low and high ABI was still associated with significant reductions in risk of all-cause mortality of 0.59 (95% CI: 0.51–0.67) and 0.66 (95% CI: 0.54–0.80), respectively. The survival curve for very elderly patients with PAD by statin use is shown in Figure 1. Conclusion Statin use in the very elderly was associated with lower risk of all-cause mortality in the five-year period after diagnosis of PAD. There appears to be a mortality benefit with statin use in the very elderly with PAD, though careful consideration of benefits and side effects should be individualized in this age group. Figure 1 Funding Acknowledgement Type of funding source: None

scholarly journals Leptin in Very Elderly Patients with Coronary Artery Disease

2021 ◽  
Vol 12 (4) ◽  
pp. 145-151
Author(s):  
Svetlana V. Topolyanskaya ◽  
Tatyana A. Eliseeva ◽  
Olga N. Vakulenko ◽  
Leonid I. Dvoretski
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Elderly Patients ◽  
Very Elderly ◽  
Artery Disease

Prognosis of very elderly patients with coronary artery disease treated with percutaneous revascularization

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Marcello Marino ◽  
Andrea Demarchi ◽  
Michele Cacucci ◽  
Antonio Catanoso ◽  
Paolo Valentini ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Elderly Patients ◽  
Very Elderly ◽  
Artery Disease ◽  
Percutaneous Revascularization
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