Jaw Metastasis from a Prostate Adenocarcinoma Associated with Numb Chin Syndrome: Case Report

2021 ◽  
Vol 3 (4) ◽  
pp. 1042-1046
Author(s):  
Nara Ielo ◽  
Mariel Biancardi ◽  
Felipe Trevisan ◽  
Cezar Coimbra ◽  
Carlos Zelandi-Filho ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Bone Metastasis ◽  
Immunohistochemical Analysis ◽  
Prostate Adenocarcinoma ◽  
Oral Exam ◽  
Body Region ◽  
Positive Staining ◽  
Numb Chin Syndrome ◽  
The Right ◽  
Jaw Osteonecrosis

AbstractNumb chin syndrome is an uncommon maxillofacial manifestation involving mental neuropathic complications of mandibular bone metastasis with prostate adenocarcinoma. We report a case of a male, 68 years, with a history of bone tibia and spinal metastatic prostate cancer, undergoing bilateral orchiectomy for hormonal blockade and chemotherapy; disease progression was confirmed by bone scintigraphy which noted no critical points but an increase in alkaline phosphatase; therapy with abiraterone and zoledronic acid quarterly was introduced 1 year after diagnosis. The patient attended a dental appointment after 10 months of bisphosphonate use, complaining of a “tingling” sensation in the right chin mental region, 6 months after tooth extraction, with diagnostic hypothesis of medication-related jaw osteonecrosis. Intra-oral exam showed edema in the right mandibular body region extending to the painless, hardened chin, with exudate drainage as compression. An incisional biopsy was performed and anatomopathological and immunohistochemical analysis showed positive staining for cytokines and NKX3, confirming the diagnosis of adenocarcinoma metastasis. The patient was referred to continue treatment with radiotherapy and, subsequently, Xofigo and zoledronic acid to improve symptomatology and control of the adenocarcinoma. Facial numbness should alert clinicians to the potential of metastatic disease in any patient who presents with chin or jaw numbness and has no other obvious cause for their complaint, and early differential diagnosis between jaw osteonecrosis and bone metastasis in the jaw is important for immediate management and improvement in treatment and quality of life.

Solitary extra-skeletal sinonasal metastasis from a primary skeletal Ewing's sarcoma

2011 ◽  
Vol 125 (8) ◽  
pp. 861-864 ◽  
Author(s):  
S M Hayes ◽  
T N Jani ◽  
S M Rahman ◽  
S Jogai ◽  
P G Harries ◽  
...  
Keyword(s):  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
In Situ Hybridisation ◽  
Immunohistochemical Analysis ◽  
Skeletal Metastasis ◽  
Malignant Tumour ◽  
Positive Staining ◽  
Transnasal Approach ◽  
Atypical Cells ◽  
The Right

AbstractIntroduction:Ewing's sarcoma is a rare, malignant tumour predominantly affecting young adolescent males. We describe a unique case of an isolated extra-skeletal metastasis from a skeletal Ewing's sarcoma primary, arising in the right sinonasal cavity of a young man who presented with severe epistaxis and periorbital cellulitis.Results:Histologically, the lesion comprised closely packed, slightly diffuse, atypical cells with round, hyperchromatic nuclei, scant cytoplasm and occasional mitotic figures, arranged in a sheet-like pattern. Immunohistochemical analysis showed positive staining only for cluster of differentiation 99 glycoprotein. Fluorescent in situ hybridisation identified the Ewing's sarcoma gene, confirming the diagnosis.Management:Complete surgical resection was achieved via a minimally invasive endoscopic transnasal approach; post-operative radiotherapy. Ten months post-operatively, there were no endoscopic or radiological signs of disease.Conclusion:Metastatic Ewing's sarcoma within the head and neck is incredibly rare and can pose significant diagnostic and therapeutic challenges. An awareness of different clinical presentations and distinct histopathological features is important to enable early diagnosis. This case illustrates one potential management strategy, and reinforces the evolving role of endoscopic transnasal approaches in managing sinonasal cavity and anterior skull base tumours.

Meningeal Solitary Fibrous Tumor as an Unusual Cause of Exophthalmos: Case Report and Review of the Literature

Neurosurgery ◽  
2001 ◽  
Vol 48 (6) ◽  
pp. 1362-1366 ◽  
Author(s):  
Jung Yong Ahn ◽  
Jeong Yun Shim ◽  
Woo Ick Yang ◽  
Tai Seung Kim
Keyword(s):  
Differential Diagnosis ◽  
Solitary Fibrous Tumor ◽  
Immunohistochemical Analysis ◽  
Positive Staining ◽  
Presumptive Diagnosis ◽  
Anterior Clinoid Process ◽  
Orbitozygomatic Approach ◽  
Spindle Cell Proliferation ◽  
Fibrous Tumor ◽  
The Right

Abstract OBJECTIVE AND IMPORTANCE We report an extremely rare case of a patient with meningeal solitary fibrous tumor with orbital involvement presenting as unilateral exophthalmos. This rare tumor should be considered in the differential diagnosis for aggressive dural-based lesions. CLINICAL PRESENTATION A 54-year-old man presented with a protruded eyeball on the right side and left hemiparesis. Computed tomography and magnetic resonance imaging demonstrated a huge mass, markedly enhanced in and around the right anterior clinoid process, which extended to the orbit and middle cranial fossa. Cerebral angiography revealed a richly vascular tumor fed by branches of both the right external and internal carotid arteries. A presumptive diagnosis of meningioma or hemangiopericytoma was considered. INTERVENTION The tumor was exposed through an orbitozygomatic approach. At surgery, the tumor was grossly firm to hard and had destroyed the dura, orbital roof, anterior clinoid process, temporal bone, and muscle. Histological analysis revealed that the tumor was composed of spindle-cell proliferation in a collagen-rich background, but it exhibited regional variations. The vascular network demonstrated irregular vascular lumina with a “hemangiopericytoma-like” pattern. Histological features included high cellularity and a high degree of pleomorphism. Immunohistochemical analysis of the tumor demonstrated diffuse positive staining for CD34 and vimentin. The tumor displayed no positive staining for cytokeratin, epithelial membrane antigen, glial fibrillary antigenic protein, S-100 protein, and factor XIII. CONCLUSION Meningeal solitary fibrous tumor is considered a unique pathological entity. Wider use of immunohistochemical screening should enable analysis of the real incidence of these tumors; larger series and longer follow-up duration will allow conclusions to be drawn regarding treatment and prognosis. Differential diagnosis is discussed and the literature is reviewed.

scholarly journals Phakomatous Choristoma of the Orbit with Inferior Oblique Muscle Involvement

2021 ◽  
Vol 62 (9) ◽  
pp. 1287-1291
Author(s):  
Seo Yoon Heo ◽  
Haeng-Jin Lee ◽  
Myoung Ja Chung ◽  
Min Ahn
Keyword(s):  
Bone Erosion ◽  
Immunohistochemical Analysis ◽  
Male Infant ◽  
Orbital Tumor ◽  
Oblique Muscle ◽  
Positive Staining ◽  
Inferior Oblique Muscle ◽  
Muscle Involvement ◽  
Orbital Mass ◽  
The Right

Purpose: We report a case of phakomatous choristoma presenting as an orbital tumor with involvement of the inferior oblique muscle. Case summary: A 2-month-old male infant presented to our clinic with a right orbital mass that had been present since birth. Magnetic resonance imaging demonstrated a homogenous enhanced well-defined mass located in the inferomedial portion of the right orbit without bone erosion. By transconjunctival orbitotomy, the orbital tumor invading the inferior oblique muscle was identified and resected. Histopathology showed a thick basement membrane surrounding pseudoglandular structures embedded in a collagenous stroma, psammomatous calcific foci in the stroma, and eosinophilic material in the lumen. Immunohistochemical analysis showed positive staining for S-100 and cytokeratin. On histopathological evaluation, the tumor was diagnosed as phakomatous choristoma. Conclusions: To our knowledge, this is the first report in South Korea of phakomatous choristoma of the orbit with involvement of the inferior oblique muscle. Although rare, phakomatous choristoma should be included in the differential diagnosis of tumors occurring on the inferomedial side of the orbit.

scholarly journals Immunohistochemical detection of procalcitonin in fibrolamellar hepatocellular carcinoma

2021 ◽  
Author(s):  
Kotaro Matsumoto ◽  
Kentaro Kikuchi ◽  
Ayako Hara ◽  
Hiromichi Tsunashima ◽  
Koichi Tsuneyama ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Histopathological Examination ◽  
Epigastric Pain ◽  
Positive Staining ◽  
C Reactive Protein ◽  
Fibrolamellar Hepatocellular Carcinoma ◽  
Tumor Biopsy ◽  
Reactive Protein ◽  
Right Lobe ◽  
The Right

AbstractA 25-year-old woman with fever and epigastric pain was referred to our hospital. Blood examination showed significant liver dysfunction, markedly high C-reactive protein (CRP 19.1 mg/dL) and procalcitonin (48.3 ng/mL) levels. Dynamic computed tomography showed a tumor approximately 120 mm in size in the right lobe of the liver, but with no abscess formation. The patient was hospitalized and started on antibiotics; her CRP level improved, but the procalcitonin level did not decrease. Histopathological examination of the liver tumor biopsy revealed fibrolamellar hepatocellular carcinoma (FLC). Positive staining of the FLC with an anti-procalcitonin antibody suggested the production of procalcitonin.

scholarly journals Effect of zoledronic acid on the doxycycline-induced decrease in tumour burden in a bone metastasis model of human breast cancer

2007 ◽  
Vol 96 (10) ◽  
pp. 1526-1531 ◽  
Author(s):  
W C M Duivenvoorden ◽  
S Vukmirović-Popović ◽  
M Kalina ◽  
E Seidlitz ◽  
G Singh
Keyword(s):  
Breast Cancer ◽  
Zoledronic Acid ◽  
Bone Metastasis ◽  
Human Breast Cancer ◽  
Tumour Burden ◽  
Human Breast ◽  
Metastasis Model

Peritricuspid annular prostate pellet

2021 ◽  
Vol 14 (2) ◽  
pp. e238076
Author(s):  
Bryan O'Sullivan ◽  
Richard Tanner ◽  
Peter Kelly ◽  
Gerard Fahy
Keyword(s):  
Right Ventricle ◽  
Left Ventricular Outflow Tract ◽  
Ventricular Outflow Tract ◽  
Prostate Adenocarcinoma ◽  
Left Ventricular ◽  
Premature Ventricular Contractions ◽  
Left Ventricular Outflow ◽  
Metallic Object ◽  
The Right

A 75-year-old was treated for prostate adenocarcinoma with brachytherapy in September 2018. A routine follow-up chest radiograph 3 months later revealed a metallic object of the same dimensions as a brachytherapy pellet located in the right ventricle. Further imaging showed the brachtherapy pellet was located in the anterobasal right ventricular endocardium close to the tricuspid valve. Frequent asymptomatic premature ventricular contractions were observed with likely origin from the left ventricular outflow tract, an area remote from the site of the pellet. The patient remains asymptomatic and subsequent imaging shows that the position of the pellet has not changed.

scholarly journals Effect of Trehalose Supplementation on Autophagy and Cystogenesis in a Mouse Model of Polycystic Kidney Disease

Nutrients ◽  
2018 ◽  
Vol 11 (1) ◽  
pp. 42 ◽  
Author(s):  
Li-Fang Chou ◽  
Ya-Lien Cheng ◽  
Chun-Yih Hsieh ◽  
Chan-Yu Lin ◽  
Huang-Yu Yang ◽  
...  
Keyword(s):  
Drinking Water ◽  
Kidney Disease ◽  
Mouse Model ◽  
Polycystic Kidney Disease ◽  
Renal Cyst ◽  
Pure Water ◽  
Immunohistochemical Analysis ◽  
Positive Staining ◽  
Wild Type ◽  
Polycystic Kidney

Autophagy impairment has been demonstrated in the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD) and could be a new target of treatment. Trehalose is a natural, nonreducing disaccharide that has been shown to enhance autophagy. Therefore, we investigated whether trehalose treatment reduces renal cyst formation in a Pkd1-hypomorphic mouse model. Pkd1 miRNA transgenic (Pkd1 miR Tg) mice and wild-type littermates were given drinking water supplemented with 2% trehalose from postnatal day 35 to postnatal day 91. The control groups received pure water or 2% sucrose for the control of hyperosmolarity. The effect on kidney weights, cystic indices, renal function, cell proliferation, and autophagic activities was determined. We found that Pkd1 miR Tg mice had a significantly lower renal mRNA expression of autophagy-related genes, including atg5, atg12, ulk1, beclin1, and p62, compared with wild-type control mice. Furthermore, immunohistochemical analysis showed that cystic lining cells had strong positive staining for the p62 protein, indicating impaired degradation of the protein by the autophagy-lysosome pathway. However, trehalose treatment did not improve reduced autophagy activities, nor did it reduce relative kidney weights, plasma blood urea nitrogen levels, or cystatin C levels in Pkd1 miR Tg mice. Histomorphological analysis revealed no significant differences in the renal cyst index, fibrosis score, or proliferative score among trehalose-, sucrose-, and water-treated groups. Our results demonstrate that adding trehalose to drinking water does not modulate autophagy activities and renal cystogenesis in Pkd1-deficient mice, suggesting that an oral supplement of trehalose may not affect the progression of ADPKD.

scholarly journals Correction to: Jaw Metastasis from a Prostate Adenocarcinoma Associated with Numb Chin Syndrome: Case Report

2021 ◽  
Author(s):  
Nara Ielo ◽  
Mariel Biancardi ◽  
Felipe Trevisan ◽  
Cezar Coimbra ◽  
Carlos Zelandi-Filho ◽  
...  
Keyword(s):  
Case Report ◽  
Prostate Adenocarcinoma ◽  
Numb Chin Syndrome

ROLE OF THE HYALURONAN-PRODUCING TENOSYNOVIUM IN PREVENTING ADHESION FORMATION DURING HEALING OF FLEXOR TENDON INJURIES

Hand Surgery ◽  
2012 ◽  
Vol 17 (01) ◽  
pp. 13-17 ◽  
Author(s):  
Masaharu Yagi ◽  
Yasuhiro Mitsui ◽  
Masafumi Gotoh ◽  
Naoto Sato ◽  
Kenji Yoshida ◽  
...  
Keyword(s):  
Flexor Tendon ◽  
Adhesion Formation ◽  
Immunohistochemical Analysis ◽  
Tendon Injuries ◽  
White Leghorn ◽  
Group I ◽  
Flexor Tendon Injuries ◽  
The Right ◽  
Hematoxylin Eosin

Flexor tendons of white Leghorn chickens (n = 25) were used for this study. One chicken was used as a normal control (no surgery), and the remaining 24 were used for experiments. After partial tendon-severing in both legs of 24 chickens, the right and the left leg were treated differently, thereby creating two groups: Group I, in which the tenosynovium was preserved, and Group II, in which the tenosynovium was removed. Hematoxylin-eosin staining was performed to observe adhesions; immunohistochemical analysis was used to localize HA. HA production was noted in granulation tissue invading between the tendon stumps in both groups; however, HA expression in the tenosynovium was observed only in Group I where adhesion formation was minimal. The HA-producing tenosynovium plays a crucial role in preventing adhesion formation in this model of flexor tendon injuries.

Syringoid Eccrine Carcinoma of the Foot: Report of a Rare Cutaneous Adnexal Neoplasm

2017 ◽  
Vol 25 (7) ◽  
pp. 659-664 ◽  
Author(s):  
Woo Cheal Cho ◽  
Brian Wagner ◽  
Melissa Gulosh ◽  
Zendee Elaba
Keyword(s):  
African American Woman ◽  
S100 Protein ◽  
American Woman ◽  
Neck Region ◽  
Immunohistochemical Analysis ◽  
Reticular Dermis ◽  
Plantar Surface ◽  
Adnexal Tumor ◽  
Eccrine Carcinoma ◽  
The Right

Syringoid eccrine carcinoma is a rare malignant adnexal tumor that typically presents in the head and neck region. Involvement of the extremities is uncommon, with only a few cases reported in the literature. Here, we report our experience with a rare case of syringoid eccrine carcinoma occurring on the plantar surface of the right foot in a 47-year-old African American woman. Histologically, incisional biopsy revealed a tumor consisting of tubulocystic structures lined by basaloid cells with an infiltrative growth pattern, extending from the reticular dermis to the deep biopsy margin. Some of the nests and cords of basaloid cells displayed syringoma-like, tadpole morphology. Immunohistochemical analysis showed diffuse immunoreactivity with monoclonal carcinoembryonic antigen, epithelial membrane antigen, cytokeratin 7, S100 protein, and CD117. These morphologic and immunophenotypic features were most consistent with syringoid eccrine carcinoma. Syringoid eccrine carcinoma has a broad differential diagnosis which must be carefully ruled out by morphology, immunohistochemistry, and thorough metastatic survey with imaging studies. Our case highlights the importance of recognizing this rare entity, which is locally destructive and has a propensity for recurrence. To the best of our knowledge, this is the first reported case of syringoid eccrine carcinoma presenting on the sole of the foot.

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