Effects of nadolol treatment on renal and hepatic hemodynamics and function in cirrhotic patients with portal hypertension

1984 ◽  
Vol 108 (4) ◽  
pp. 1167-1172 ◽  
Author(s):  
Angelo Gatta ◽  
David Sacerdoti ◽  
Carlo Merkel ◽  
Loredano Milani ◽  
Giorgio Battaglia ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Hepatic Hemodynamics ◽  
Cirrhotic Patients ◽  
And Function

scholarly journals The study of hepatic hemodynamics: research activity or clinical tool?

2013 ◽  
pp. 201-206
Author(s):  
Claudio Puoti ◽  
Lia Bellis
Keyword(s):  
Portal Hypertension ◽  
Venous Pressure ◽  
Preoperative Assessment ◽  
Clinical Tool ◽  
Research Activity ◽  
Acute Variceal Bleeding ◽  
Routine Work ◽  
Hepatic Hemodynamics ◽  
Pros And Cons ◽  
Cirrhotic Patients

Portal hypertension is a progressive complication of cirrhosis. Therefore, the management of a patient with cirrhosis and gastrointestinal bleeding depends largely on the stage of the portal hypertension. The patient may be in the pre-variceal stage or present with acute variceal bleeding, in which case the objectives are to control the current hemorrhage and prevent recurrence. In clinical practice, the severity of portal hypertension can be estimated, reliably and safely, by transjugular measurement of the hepatic venous pressure gradient (HVPG). After a brief review of the pathophysiology of portal hypertension in cirrhosis, the authors describe the technique used to measure transjugular HVPG, its prognostic value in patients with cirrhosis, the pros and cons of including this procedure in routine work-ups of these patients, and its potential roles in monitoring responses to treatment and in the preoperative assessment of cirrhotic patients undergoing hepatic resection.

PROGNOSTIC VALUE OF COMBINATION AIMS65 AND MELD SCORES IN CIRRHOTIC PATIENTS WITH ACUTE VARICEAL BLEEDING

2019 ◽  
pp. 35-40
Author(s):  
Thi Nhung Nguyen ◽  
Trung Nam Phan ◽  
Van Huy Tran
Keyword(s):  
Clinical Practice ◽  
Portal Hypertension ◽  
Key Words ◽  
Variceal Bleeding ◽  
Prognostic Value ◽  
High Rate ◽  
Central Hospital ◽  
Acute Variceal Bleeding ◽  
Cirrhotic Patients ◽  
Sensitivity Specificity

Bacground: Variceal bleeding is a severe complication of portal hypertension due to cirrhosis with high rate of motality, hence, predicting early rebleeding and mortality in cirrhotic patients with acute variceal bleeding is vital in clinical practice. Objectives: To evaluate the prognostic value of the combination of AIMS65 and MELD scores in predicting first 5 days in-hospital rebleeding and mortality in cirrhotic patients with acute variceal bleeding. Materials and Methods: 44 cirrhotic patients with acute variceal bleeding hospitalized at Hue Central Hospital. MELD and AIMS65 scores were calculated within the first 24 hours and monitoring rebleeding and mortality in the first 5 days in these patients. Results: AIMS65, MELD scores can predict first 5 days rebleeding and mortality with AUROC are 0.81, 0.69 and 0.92, 0.95, respectively. Combination of AIMS65 and MELD scores can predict first 5 days in hospital rebleeding with AUROC is 0.84, sensitivity 83.3%, specificity 81.6% (p<0.001) and mortality with AUROC is 0.96, sensitivity 100%, specificity 92.7% (p<0.001). Conclusions: The combination of AIMS65 and MELD scores increased the sensitivity, specificity and prognostic value in predicting first 5 days in-hospital rebleeding and mortality in cirrhotic patients with acute variceal bleeding in compare to each single scores. Key words: AiMS65 score, MELd, acute variceal bleeding

Non invasive diagnosis of portal hypertension in cirrhotic patients

2008 ◽  
Vol 32 (6) ◽  
pp. 80-87 ◽  
Author(s):  
F. Vizzutti ◽  
U. Arena ◽  
L. Rega ◽  
M. Pinzani
Keyword(s):  
Portal Hypertension ◽  
Non Invasive ◽  
Cirrhotic Patients

scholarly journals Child-Na Score: A Predictive Model for Survival in Cirrhotic Patients with Symptomatic Portal Hypertension Treated with TIPS

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e79637 ◽  
Author(s):  
Hui Chen ◽  
Ming Bai ◽  
Xingshun Qi ◽  
Lei Liu ◽  
Chuangye He ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Predictive Model ◽  
Cirrhotic Patients

Hepatic resection for hepatocellular carcinoma in cirrhotic patients with portal hypertension

2016 ◽  
Vol 20 (4) ◽  
pp. 149-156 ◽  
Author(s):  
Hazem M. Zakaria ◽  
Emad H. Gad ◽  
Ali Nada ◽  
Anwar A. Abdelaleem ◽  
Doha Maher ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Portal Hypertension ◽  
Hepatic Resection ◽  
Cirrhotic Patients

scholarly journals Hematological Indices in Portal Hypertension: Cirrhosis versus Noncirrhotic Portal Hypertension

2018 ◽  
Vol 7 (8) ◽  
pp. 196 ◽  
Author(s):  
Abdurrahman Sahin ◽  
Hakan Artas ◽  
Nurettin Tunc ◽  
Mehmet Yalniz ◽  
Ibrahim Bahcecioglu
Keyword(s):  
Portal Hypertension ◽  
Retrospective Study ◽  
Radiological Findings ◽  
Hematological Indices ◽  
Noncirrhotic Portal Hypertension ◽  
End Stage Liver Disease ◽  
Cirrhotic Patients ◽  
Hematological Abnormalities ◽  
End Stage ◽  
Cirrhotic Group

Portal hypertension (PHT) leads to several alterations on hematological indices (HI). The aim of the study is to investigate the differences in HI between cirrhotic subjects and subjects who have noncirrhotic PHT (NCPHT). This retrospective study included 328 patients with PHT (239 cirrhosis and 89 NCPHT). Demographic and clinical features, endoscopic and radiological findings, and HI including neutrophil to lymphocyte ratio (NLR) at the time of PHT diagnosis were recorded. Severity of cirrhosis was assessed according to the Child–Turcotte–Pugh (CTP) classification and Model for End-Stage Liver Disease (MELD) scores. Hematological abnormalities were found in 92.5% of cirrhotic patients and in 55.1% of patients with NCPHT (p < 0.001). While thrombocytopenia was the most common HI in patients with cirrhosis, anemia was the most prevalent HI in NCPHT group. In the cirrhotic group, the NLR was the only parameter to differentiate each CTP group from two others. The NLR value increased with the severity of cirrhosis (2.28 ± 0.14 in CTP-A, 2.85 ± 0.19 in CTP-B and 3.26 ± 0.37 in CTP-C). The AUROC of NLR was 0.692 for differentiating compensated cirrhotic patients from decompensated. Hematological abnormalities are more prevalent and more severe in cirrhotic patients compared to patients with NCPHT. NLR may be used to assess the severity of cirrhosis.

Sign in / Sign up

Export Citation Format

Share Document