Effects of antilipolytic agents on peroxisomal β-oxidation of fatty acids in rat liver

1983 ◽  
Vol 32 (11) ◽  
pp. 1807-1809 ◽  
Author(s):  
T. Locci-Cubeddu ◽  
E. Bergamini
Keyword(s):  
1999 ◽  
Vol 40 (4) ◽  
pp. 601-609 ◽  
Author(s):  
Kathleen Croes ◽  
Minne Casteels ◽  
Martine Dieuaide-Noubhani ◽  
Guy P. Mannaerts ◽  
Paul P. Van Veldhoven

1965 ◽  
Vol 209 (4) ◽  
pp. 773-780 ◽  
Author(s):  
Helen M. Tepperman ◽  
Jay Tepperman

The aggregate hexosemonophosphate dehydrogenase (HMPD) activity was found to be higher in livers of rats fed a diet containing saturated fat (hydrogenated coconut oil = H) for 7 days and fasted for 48 hr than it was in similarly prepared animals fed a corn oil (CO) diet. Later, a liver HMPD-increasing effect of feeding H was found in nonfasted animals. Lipogenesis (i.e., the incorporation of acetate-1-C14 into fatty acids by liver slices) was shown to be as low or lower in the H group as in the CO. Liver slices prepared from H and CO diet adapted rats were incubated with either acetate-1-C14 or palmitate-1-C14 and the extent of incorporation of C14 into individual fatty acids was measured. With both substrates more radioactivity was found in 16:1, 18:0, and 18:1 in the case of H-fed animals. It is proposed that a component of the signal for eliciting increased NADP-linked enzyme activity in the H rats was an increased rate of oxidation of NADPH attendant on monoene formation and chain lengthening.


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