Unloading reflex as prognosis factor in scoliosis

Abstract Background The benefit of arterial revascularization in coronary surgery remains controversial. The incremental value of additional grafts to the left internal thoracic artery (ITA) has been mainly assessed according to the number of arterial grafts, possibly limiting the detection of its actual impact. We analyzed the influence of the number of distal arterial anastomoses (DAA) performed on late mortality in patients having received from one to three arterial grafts. Methods Retrospective review of 3685 primary isolated coronary artery bypass grafting (CABG) performed from 1989 to 2014 was conducted with a 13-year mean follow-up. One arterial graft (SITA) was used in 969 patients, two arterial grafts, ITA or gastroepiploic artery (GEA), in 1883 patients (BITA: 1644; SITA+GEA: 239), and three arterial grafts in 833 patients (BITA+GEA). Totally, 795 patients (22%) received one DAA, 1142 patients (31%) two, 1337 patients (36%) three, and 411 patients (11%) four or more. A sub-group analysis was done in the 2104 patients with 3-vessel disease who received at least 2 arterial grafts. Results In this series the early mortality was 1.6% and it was not influenced by the surgical technique. Late mortality was significantly influenced by age, gender, heart failure, LV ejection fraction, diabetes status, complete revascularization, number of arterial grafts, number of DAA, both ITA, sequential ITA graft, GEA graft. In multivariable analysis with Cox regression model, the number of DAA was the only technical significant independent prognosis factor of late survival (p < 0.0001), predominant over both ITA, complete revascularization and number of arterial grafts. The impact of the number of DAA on survival was found discriminant from 1 to 3; after 3 there was no more additional effect. In 3-vessel disease patients who received at least 2 arterial grafts, the number of DAA remained a significant independent prognosis factor of late survival (p < 0.0001). Conclusions The number of distal arterial anastomoses is an independent predictor of long-term survival, predominant over the number of arterial grafts and the completeness of the revascularization; higher the number, better the late survival. It is a strong support of the extensive use of arterial grafting in CABG.

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Reflex Responses Induced by Tooth Unloading

Journal of Neurophysiology ◽

10.1152/jn.2000.84.2.1088 ◽

2000 ◽

Vol 84 (2) ◽

pp. 1088-1092 ◽

Cited By ~ 29

Author(s):

Kemal S. Türker ◽

Melissa Jenkins

Keyword(s):

Local Anesthetic ◽

Muscle Activity ◽

Masseter Muscle ◽

Horizontal Direction ◽

Reflex Response ◽

Maxillary Incisor ◽

Static Force ◽

Incisor Tooth ◽

Long Latency ◽

Unloading Reflex

The reflex response of the masseter muscle to the rapid unloading of a single maxillary incisor tooth was studied. Unloading of a static force of 2 N in the horizontal direction resulted in a short-latency excitation, inhibition, and long-latency excitation of masseter muscle activity occurring at latencies of approximately 13, 20, and 40 ms, respectively, with a corresponding change in bite force occurring slightly later in each case. Following the blocking of periodontal input by the injection of local anesthetic around the stimulated tooth, inhibitory responses were abolished. Therefore, it is concluded that the observed masseteric inhibition was caused by the unloading of periodontal mechanoreceptors and thus that these receptors may contribute to the jaw unloading reflex.

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P-226 Analysis of Hispanic Latino American patients with colorectal cancer, clinical features and laterality as a prognosis factor of overall survival

Annals of Oncology ◽

10.1016/j.annonc.2020.04.308 ◽

2020 ◽

Vol 31 ◽

pp. S164

Author(s):

G. Calderillo-Ruiz ◽

C. Diaz ◽

D. Heredia ◽

B. Carbajal-López ◽

H. Lopez Basave ◽

...

Keyword(s):

Colorectal Cancer ◽

Overall Survival ◽

Clinical Features ◽

Prognosis Factor ◽

Latino American

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CASC2c as an unfavorable prognosis factor interacts with miR-101 to mediate astrocytoma tumorigenesis

Cell Death and Disease ◽

10.1038/cddis.2017.11 ◽

2017 ◽

Vol 8 (3) ◽

pp. e2639-e2639 ◽

Cited By ~ 17

Author(s):

Changhong Liu ◽

Yingnan Sun ◽

Xiaoling She ◽

Chaofeng Tu ◽

Xiping Cheng ◽

...

Keyword(s):

Prognosis Factor

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Angiolymphatic invasion as a prognostic fator in resected N0 pancreatic adenocarcinoma

ABCD Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) ◽

10.1590/0102-6720201700010012 ◽

2017 ◽

Vol 30 (1) ◽

pp. 42-46

Author(s):

Ricardo Vitor Silva de ALMEIDA ◽

Adhemar Monteiro PACHECO-JR ◽

Rodrigo Altenfelder SILVA ◽

André de MORICZ ◽

Tércio de CAMPOS

Keyword(s):

Pancreatic Cancer ◽

Pancreatic Adenocarcinoma ◽

Perineural Invasion ◽

Prognosis Factor ◽

Curative Intent ◽

Angiolymphatic Invasion ◽

Digestive Cancers ◽

Cancer Tumor ◽

Group Survival ◽

Hematoxylin Eosin

ABSTRACT Background: Pancreatic adenocarcinoma remains one of the worst digestive cancers. Surgical resection is the main target when treating a patient with curative intent. Aim: To assess angiolymphatic invasion as a prognostic factor in resected pN0 pancreatic cancer. Methods: Thirty-eight patients were submitted to pancreatoduodenectomy due to head pancreatic cancer. Tumor size, margins, lymph nodes, pTNM staging, angiolymphatic and perineural invasion were described in the pathologists' reports. Results: Most patients were female. Overall median survival was 13 months. Gemcitabine was the regimen of choice for chemotherapy in selected patients; however, it did not improve overall survival. pR0 resection had better survival compared with pR1. Within the pN0 group, survival was significantly better in patients without angiolymphatic invasion. Conclusion: Angiolymphatic invasion in N0 pancreatoduodenectomy can be demonstrated by the Hematoxylin-Eosin stain and may predict a poor prognosis factor for those patients.

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The Clinical Value of Red Blood Cell Distribution Width as a Prognosis Factor and Severity Marker in Sepsis and Septic Shock

Central European Journal of Clinical Research ◽

10.2478/cejcr-2019-0009 ◽

2019 ◽

Vol 2 (1) ◽

pp. 58-66

Author(s):

Emanuel Moisă ◽

Silvius Negoiţă ◽

Dan Corneci

Keyword(s):

Septic Shock ◽

Blood Cell ◽

Red Blood Cell ◽

Hematological Parameter ◽

Component Part ◽

Cell Distribution ◽

Prognosis Factor ◽

Distribution Width ◽

Severity Scores ◽

Red Blood Cell Distribution

AbstractRed blood cell distribution width (RDW) is a hematological parameter usually measured with every complete blood count. Its place in daily practice is mainly in the differential diagnosis of anemia, but nowadays, researchers are focused on different approaches for the erythrocyte’s changes in function and morphology.Sepsis and its most advanced form, septic shock, induces profound disturbances into organ system’s function and morphology. The red blood cells physiology and structure are directly and indirectly altered by these im balances produced in sepsis. RDW was studied in many diseases, like acute heart failure, acute stroke, inflammatory bowel diseases, chronic lung diseases and cancer, but also in sepsis. Its changes are seen to be mainly associated with prognosis. Higher values of RDW are correlated with mortality and severity of illnes in septic and all-cause critically ill patients. RDW was studied also as an independent variable in different predictive scores and some studies suggest it should be introduced in the scores use on a daily basis in critical care settings and emergency departments.In this review we will focus on how RDW was associated with mortality and severity of illness in the recent literature, as an independent prognosis factor and as a component part in different predictive and severity scores.

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