Neonatal sterilization of rodents with steroid hormones: 5. A note on the influence of neonatal treatment with estradiol benzoate or testosterone propionate on steroid metabolism in the brain and testes of adult male rats

1974 ◽  
Vol 5 (3) ◽  
pp. 227-231 ◽  
Author(s):  
A.A. Joseph ◽  
Fred A. Kincl
Keyword(s):  
Steroid Hormones ◽  
Adult Male ◽  
Testosterone Propionate ◽  
Estradiol Benzoate ◽  
Male Rats ◽  
Steroid Metabolism ◽  
Neonatal Treatment ◽  
The Brain

EFFECTS OF 17β-HYDROXY-4-ANDROSTEN-19-OL-3-ONE (19-HYDROXYTESTOSTERONE) AND 5α-ANDROSTAN-17β-OL-3-ONE (DIHYDROTESTOSTERONE) ON ASPECTS OF SEXUAL BEHAVIOUR IN CASTRATED MALE RATS

1974 ◽  
Vol 61 (1) ◽  
pp. 105-115 ◽  
Author(s):  
R. F. PARROTT
Keyword(s):  
Adult Male ◽  
Sexual Behaviour ◽  
Testosterone Propionate ◽  
Male Rats ◽  
Organ Weights ◽  
Refractory Periods ◽  
Peripheral Effect ◽  
Rate Of Decline ◽  
The Brain ◽  
Experienced Adult

SUMMARY The ability of 19-hydroxytestosterone propionate (150 μg/day) to maintain sexual behaviour, accessory organ weights and the number of penile spines in experienced adult male rats in the 5 weeks after castration was compared with intact males and castrated animals receiving testosterone propionate (75 μg/day) or oil treatment. In a second experiment a group of male rats receiving dihydrotestosterone propionate (150 μg/day) was also included. 19-Hydroxytestosterone did not maintain ejaculatory performance but animals that ejaculated had refractory periods similar to those in intact and testosterone-treated groups. Dihydrotestosterone, however, slowed the rate of decline of ejaculatory performance but the refractory periods were comparable to those in castrated controls. The former action of dihydrotestosterone was attributed to its stimulatory effect on peripheral structures, especially the penile spines. 19-Hydroxytestosterone was shown to have no peripheral effect at doses up to 1800 μg every other day. The results are discussed in terms of a theory of testosterone action involving aromatization in the brain and 5α-reduction peripherally.

scholarly journals Altered sexual differentiation of hepatic uridine diphosphate glucuronyltransferase by neonatal hormone treatment in rats

1979 ◽  
Vol 180 (2) ◽  
pp. 313-318 ◽  
Author(s):  
Coral A. Lamartiniere ◽  
Cindy S. Dieringer ◽  
Etsuko Kita ◽  
George W. Lucier
Keyword(s):  
Enzyme Activity ◽  
Adult Male ◽  
Sexual Differentiation ◽  
Reproductive Tract ◽  
Testosterone Propionate ◽  
Hormone Treatment ◽  
Male Rats ◽  
Ventral Prostate ◽  
Uridine Diphosphate ◽  
Neonatal Administration

The hepatic microsomal enzyme UDP-glucuronyltransferase undergoes a complex developmental pattern in which enzyme activity is first detectable on the 18th day of gestation in rats. Prepubertal activities are similar for males and females. However, postpubertal sexual differentiation of enzyme activity occurs in which male activities are twice those of females. Neonatal administration of testosterone propionate or diethylstilboestrol to intact animals resulted in lowered UDP-glucuronyltransferase activity in liver microsomal fractions of adult male rats, whereas no changes were observed in the adult females and prepubertal male and female animals. Neonatal administration of testosterone propionate and diethylstilboestrol adversely affected male reproductive-tract development as evidenced by decreased weights of testes, seminal vesicles and ventral prostate. Diethylstilboestrol also markedly decreased spermatogenesis. Hypophysectomy of adult male rats resulted in negative modulation of microsomal UDP-glucuronyltransferase and prevented the sexual differentiation of enzyme activity. In contrast hypophysectomy had no effect on female UDP-glucuronyltransferase activity. A pituitary transplant under the kidney capsule was not capable of reversing the enzyme effects of hypophysectomy, therefore suggesting that the male pituitary factor(s) responsible for positive modulation of UDP-glucuronyltransferase might be under hypothalamic control in the form of a releasing factor. Neonatal testosterone propionate and diethylstilboestrol administration apparently interfered with the normal sequence of postpubertal UDP-glucuronyltransferase sexual differentiation.

The effect of a single injection of estradiol benzoate on thyroid function in intact male rats

1968 ◽  
Vol 46 (4) ◽  
pp. 697-700 ◽  
Author(s):  
K. Brown-Grant
Keyword(s):  
Body Weight ◽  
Thyroid Gland ◽  
Thyroid Function ◽  
Dose Level ◽  
Adult Male ◽  
Single Injection ◽  
Estradiol Benzoate ◽  
Male Rats ◽  
Intact Male ◽  
Federation Proc

The changes observed in the metabolism of radioiodide and radiophosphorus by the thyroid gland of intact adult male rats following a single injection of estradiol benzoate (4 μg/100 g body weight) are consistent with the suggestion (F. Labrie, G. Pelletier, and C. Fortier. Federation Proc. 26, 484 (1967). Abstr.) that at this dose level estrogen causes a hypersecretion of TSH in such animals.

Perinatal estradiol benzoate administration affects control of ventilation in adult male rats

1992 ◽  
Vol 52 (6) ◽  
pp. 1113-1116 ◽  
Author(s):  
Evelyn H. Schlenker ◽  
Max Goldman ◽  
Susan Walsh
Keyword(s):  
Adult Male ◽  
Estradiol Benzoate ◽  
Male Rats ◽  
Control Of Ventilation

Impaired spatial navigation in adult female but not adult male rats exposed to alcohol during the brain growth spurt

1988 ◽  
Vol 27 (3) ◽  
pp. 247-257 ◽  
Author(s):  
Sandra J. Kelly ◽  
Charles R. Goodlett ◽  
Sara A. Hulsether ◽  
James R. West
Keyword(s):  
Adult Female ◽  
Adult Male ◽  
Spatial Navigation ◽  
Male Rats ◽  
Growth Spurt ◽  
Brain Growth ◽  
Brain Growth Spurt ◽  
The Brain

Dynamics of estradiol and testosterone uptake in the brain of adult male rats

1979 ◽  
Vol 11 (5-6) ◽  
pp. 1601-1607 ◽  
Author(s):  
Steven B. Henderson ◽  
Leonard A. Ciaccio ◽  
Fred A. Kincl
Keyword(s):  
Adult Male ◽  
Male Rats ◽  
The Brain

Inductive influence of testosterone upon central sexual maturation in the rat

Development ◽  
1967 ◽  
Vol 17 (1) ◽  
pp. 171-175
Author(s):  
W. N. Adams Smith ◽  
M. T. Peng
Keyword(s):  
Corpus Luteum ◽  
Sex Hormones ◽  
Adult Male ◽  
Sexual Maturation ◽  
Male Genitalia ◽  
Testosterone Propionate ◽  
Single Injection ◽  
Male Rats ◽  
Corpora Lutea

The influence of the testis and of testosterone upon the development of the male genitalia has been extensively investigated and a number of reviews of this work have been published (Jost, 1960; Burns, 1961). However, Witschi (1957) has stressed the need to distinguish between adult sex hormones, such as testosterone, and the secretions of the immature gonad. The formation of corpora lutea in the ovaries transplanted to adult male rats which had been castrated at birth, and the absence of corpus luteum formation in ovaries transplanted to male hosts bearing transplanted testes in the neck from birth, was reported by Pfeiffer in 1936. Similar observations have been reported by Yazaki (1960) and Harris (1964). A single injection of testosterone propionate has been found to lead to permanent sterility and a loss of corpus luteum formation in the ovaries of mice (Barraclough & Leathern, 1954) and rats (Barraclough, 1961).

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