EFFECTS OF 17β-HYDROXY-4-ANDROSTEN-19-OL-3-ONE (19-HYDROXYTESTOSTERONE) AND 5α-ANDROSTAN-17β-OL-3-ONE (DIHYDROTESTOSTERONE) ON ASPECTS OF SEXUAL BEHAVIOUR IN CASTRATED MALE RATS

1974 ◽  
Vol 61 (1) ◽  
pp. 105-115 ◽  
Author(s):  
R. F. PARROTT
Keyword(s):  
Adult Male ◽  
Sexual Behaviour ◽  
Testosterone Propionate ◽  
Male Rats ◽  
Organ Weights ◽  
Refractory Periods ◽  
Peripheral Effect ◽  
Rate Of Decline ◽  
The Brain ◽  
Experienced Adult

SUMMARY The ability of 19-hydroxytestosterone propionate (150 μg/day) to maintain sexual behaviour, accessory organ weights and the number of penile spines in experienced adult male rats in the 5 weeks after castration was compared with intact males and castrated animals receiving testosterone propionate (75 μg/day) or oil treatment. In a second experiment a group of male rats receiving dihydrotestosterone propionate (150 μg/day) was also included. 19-Hydroxytestosterone did not maintain ejaculatory performance but animals that ejaculated had refractory periods similar to those in intact and testosterone-treated groups. Dihydrotestosterone, however, slowed the rate of decline of ejaculatory performance but the refractory periods were comparable to those in castrated controls. The former action of dihydrotestosterone was attributed to its stimulatory effect on peripheral structures, especially the penile spines. 19-Hydroxytestosterone was shown to have no peripheral effect at doses up to 1800 μg every other day. The results are discussed in terms of a theory of testosterone action involving aromatization in the brain and 5α-reduction peripherally.

THE COMPARATIVE ACTIONS OF TESTOSTERONE PROPIONATE AND 5α-ANDROSTAN17β-OL-3-ONE PROPIONATE ON THE REPRODUCTIVE BEHAVIOUR, PHYSIOLOGY AND MORPHOLOGY OF MALE RATS

1971 ◽  
Vol 51 (2) ◽  
pp. 241-NP ◽  
Author(s):  
H. H. FEDER
Keyword(s):  
Body Weight ◽  
Seminal Vesicle ◽  
Sexual Behaviour ◽  
Testosterone Propionate ◽  
Reproductive Behaviour ◽  
Male Rats ◽  
Male Sexual Behaviour ◽  
Testicular Weight ◽  
Seminal Vesicle Weight ◽  
Experienced Adult

SUMMARY 5α-Androstan-17β-ol-3-one in its free or in its propionate form was injected systemically (125 μg/day/rat) into sexually experienced, adult, castrated, male rats. These compounds were ineffective in activating masculine behaviour patterns, despite having measurable effects on body weight, seminal vesicle weight and penile morphology. The propionate form also had strong anti-gonadotrophic properties, since when it was injected for 6 days into intact, immature, male rats it significantly reduced testicular weight. In contrast, testosterone propionate (125 μg/day/rat) restored male sexual behaviour to the levels found before castration when injected systemically. Testosterone propionate also affected body weight, seminal vesicle weight, penile morphology and the testicular weight of immature males. These effects may have been due in part to conversion of testosterone to 5α-androstan-17β-ol-3-one, but this metabolic step does not seem to be obligatory for activation of male sexual behaviour in rats.

PERIPHERAL AND CENTRAL ANDROGENIC STIMULATION OF SEXUAL BEHAVIOUR OF CASTRATED MALE RATS

1977 ◽  
Vol 84 (4) ◽  
pp. 813-828 ◽  
Author(s):  
Rachel Hamburger-Bar ◽  
Henk Rigter
Keyword(s):  
Sexual Behaviour ◽  
Testosterone Propionate ◽  
Male Rats ◽  
Peripheral Target ◽  
Peripheral Tissues ◽  
Target Organs ◽  
The Brain ◽  
Stimulation Of ◽  
Maintenance Study

ABSTRACT The effects of androgens on the maintenance and restoration of sexual behaviour (mounts, intromissions and ejaculations) of castrated male rats were studied. In the maintenance study the rats were treated during 5 weeks, starting one day following castration. Testosterone propionate maintained sexual behaviour at an almost normal level. The androgenoestrogen intermediate 19-hydroxytestosterone propionate was unable to prevent the decline in the number of ejaculations over the weeks although this hormone maintained the post-ejaculatory refractory period in those rats that ejaculated and also maintained normal sexual latencies. In the restoration study administration of testosterone propionate during 7 weeks to long-term castrated rats restored sexual behaviour to normal. 19-Hydroxytestosterone propionate treated rats displayed mounts but no other signs of sexual behaviour. The 5α-reduced androgen dihydrotestosterone propionate did not restore sexual behaviour. Testosterone propionate and dihydrotestosterone propionate stimulated peripheral target organs; 19-hydroxytestosterone propionate was ineffective in this respect. It has been suggested that testosterone might stimulate sexual behaviour in rats in two ways, i. e., via its aromatization to oestradiol in the brain, and by stimulating growth of peripheral tissues via its 5α-reduction to dihydrotestosterone. In support for this view we have found that the combination of 19-hydroxytestosterone propionate and dihydrotestosterone propionate was effective in restoring the full pattern of sexual behaviour in castrated male rats.

scholarly journals Altered sexual differentiation of hepatic uridine diphosphate glucuronyltransferase by neonatal hormone treatment in rats

1979 ◽  
Vol 180 (2) ◽  
pp. 313-318 ◽  
Author(s):  
Coral A. Lamartiniere ◽  
Cindy S. Dieringer ◽  
Etsuko Kita ◽  
George W. Lucier
Keyword(s):  
Enzyme Activity ◽  
Adult Male ◽  
Sexual Differentiation ◽  
Reproductive Tract ◽  
Testosterone Propionate ◽  
Hormone Treatment ◽  
Male Rats ◽  
Ventral Prostate ◽  
Uridine Diphosphate ◽  
Neonatal Administration

The hepatic microsomal enzyme UDP-glucuronyltransferase undergoes a complex developmental pattern in which enzyme activity is first detectable on the 18th day of gestation in rats. Prepubertal activities are similar for males and females. However, postpubertal sexual differentiation of enzyme activity occurs in which male activities are twice those of females. Neonatal administration of testosterone propionate or diethylstilboestrol to intact animals resulted in lowered UDP-glucuronyltransferase activity in liver microsomal fractions of adult male rats, whereas no changes were observed in the adult females and prepubertal male and female animals. Neonatal administration of testosterone propionate and diethylstilboestrol adversely affected male reproductive-tract development as evidenced by decreased weights of testes, seminal vesicles and ventral prostate. Diethylstilboestrol also markedly decreased spermatogenesis. Hypophysectomy of adult male rats resulted in negative modulation of microsomal UDP-glucuronyltransferase and prevented the sexual differentiation of enzyme activity. In contrast hypophysectomy had no effect on female UDP-glucuronyltransferase activity. A pituitary transplant under the kidney capsule was not capable of reversing the enzyme effects of hypophysectomy, therefore suggesting that the male pituitary factor(s) responsible for positive modulation of UDP-glucuronyltransferase might be under hypothalamic control in the form of a releasing factor. Neonatal testosterone propionate and diethylstilboestrol administration apparently interfered with the normal sequence of postpubertal UDP-glucuronyltransferase sexual differentiation.

scholarly journals Constant lighting conditions affect sexual behaviour and hormone levels in adult male rats

Reproduction ◽  
1984 ◽  
Vol 72 (2) ◽  
pp. 435-441 ◽  
Author(s):  
B. D. Fantie ◽  
R. E. Brown ◽  
W. H. Moger
Keyword(s):  
Adult Male ◽  
Sexual Behaviour ◽  
Male Rats ◽  
Hormone Levels ◽  
Lighting Conditions

EFFECTS OF TESTOSTERONE MEDIATED OR MODULATED BY PITUITARY FACTORS

1975 ◽  
Vol 67 (1) ◽  
pp. 71-79 ◽  
Author(s):  
P. DE MOOR ◽  
M. ADAM-HEYLEN ◽  
H. VAN BAELEN ◽  
G. VERHOEVEN
Keyword(s):  
Body Weight ◽  
Testosterone Propionate ◽  
Total Body Weight ◽  
Seminal Vesicles ◽  
Female Rats ◽  
Male Rats ◽  
Intact Male ◽  
Adult Rats ◽  
Organ Weights ◽  
Total Body

SUMMARY Adult rats of both sexes were either gonadectomized or hypophysectomized and gonadectomized. Three to eight weeks later they were treated for 14 consecutive days with oil or with 75 or 200 μg testosterone propionate (TP) per 100 g body weight. The animals were killed and for each sex the gonadectomized animals were compared with the hypophysectomized-gonadectomized animals as far as their NADPH- and NADH-dependent 3α-hydroxysteroid dehydrogenases (3α-HSD) in renal microsomes, transcortin levels in serum and five organ weights relative to total body weight were concerned. For two of the latter, i.e. the relative kidney and prostatic weights, no significant differences were found. Transcortin levels, relative adrenal weights and renal NADPH-dependent 3α-HSD activities were higher in oil-treated gonadectomized animals than in oil-treated hypophysectomized-gonadectomized animals. The opposite was found for the relative weights of uterus and seminal vesicles and renal NADH-dependent 3α-HSD activities. These differences between gonadectomized and hypophysectomized-gonadectomized animals disappeared after TP treatment as far as transcortin levels were concerned but remained for the five other parameters. After gonadectomy sexual differences subsisted for all parameters studied. But whereas intact male rats had higher NADH-dependent 3α-HSD activities than female rats the opposite was found after gonadectomy. After gonadectomy plus hypophysectomy the between sex differences disappeared as far as transcortin levels were concerned but remained in the other parameters studied.

ÜBER DIE WIRKUNG INTRATESTIKULÄRER TESTOSTERONIMPLANTATIONEN AUF SEXUALVERHALTEN UND FERTILITÄT ÖSTROGENBEHANDELTER RATTENMÄNNCHEN

1961 ◽  
Vol 36 (2) ◽  
pp. 299-309 ◽  
Author(s):  
W. Hohlweg ◽  
G. Dörner ◽  
P. Kopp
Keyword(s):  
Adult Male ◽  
Sexual Behaviour ◽  
Male Rats ◽  
Testicular Function ◽  
Direct Influence ◽  
Subcutaneous Injections

ABSTRACT In adult male rats subcutaneous injections of 50 μg dienoestrol [3,4-bis (p-hydroxyphenyl)-hexa-2,4-diene] diacetate, given twice weekly, produced an inhibition of spermiogenesis and sexual behaviour resulting in total sterility. By one intratesticular implantation of 3 mg testosterone these alterations could be prevented and even rechanged in spite of continued oestrogen administration. These results prove an important direct influence of testosterone on the generative testicular function.

EFFECT OF CYPROTERONE ACETATE ON SEXUAL DIMORPHISM OF THE EXORBITAL LACRIMAL GLAND IN RATS

1969 ◽  
Vol 45 (3) ◽  
pp. 421-NP ◽  
Author(s):  
J. D. HAHN
Keyword(s):  
Sexual Dimorphism ◽  
Histological Examination ◽  
Lacrimal Gland ◽  
Sexual Behaviour ◽  
Cyproterone Acetate ◽  
Testosterone Propionate ◽  
Considerable Extent ◽  
Male Rats ◽  
Substitution Treatment ◽  
End Of Treatment

SUMMARY Adult male rats were treated with daily s.c. doses of 10 mg. cyproterone acetate for 3 weeks. Histological examination of the exorbital lacrimal glands at the end of treatment showed distinct differences compared with male controls: the histological picture showing greater resemblance to the glands of female controls. In orchidectomized rats receiving substitution treatment with testosterone propionate, cyproterone acetate 'neutralized' the effect of testosterone propionate on the exorbital lacrimal gland to a considerable extent. The possibility that this gland may play a part in the sexual behaviour of the rat is discussed.

EFFECT OF TESTOSTERONE ON NEURONAL REFRACTORY PERIODS, SEXUAL BEHAVIOUR AND LUTEINIZING HORMONE: A COMPARISON OF TIME-COURSES

1981 ◽  
Vol 89 (1) ◽  
pp. 147-155 ◽  
Author(s):  
K. M. KENDRICK ◽  
R. F. DREWETT ◽  
C. A. WILSON
Keyword(s):  
Luteinizing Hormone ◽  
Sexual Behaviour ◽  
Plasma Levels ◽  
Refractory Period ◽  
Testosterone Propionate ◽  
Stria Terminalis ◽  
Refractory Periods ◽  
Sexual Responses ◽  
Time Courses

Measurements of the refractory period of stria terminalis neurones that are sensitive to testosterone propionate, of sexual behaviour and of plasma levels of LH were taken in castrated rats at various times after initiation of treatment with testosterone propionate. Levels of LH dropped within 24 h, before there was any change in neuronal refractory periods. The period of latency to mounting, however, was reduced to its shortest only after 7–8 days and ejaculations first occurred at the same time; these sexual responses correlated in time with the reduction of the neuronal refractory period to its lowest level.

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