Occupied and unoccupied type II estrogen binding sites in human breast cancer

1987 ◽  
Vol 26 (2) ◽  
pp. 219-226 ◽  
Author(s):  
M.T.P. Lopes ◽  
M.H. Liberato ◽  
A. Widman ◽  
M.M. Brentani
Keyword(s):  
Breast Cancer ◽  
Binding Sites ◽  
Human Breast Cancer ◽  
Type Ii ◽  
Human Breast ◽  
Estrogen Binding

Estrogen Receptor in Human Breast Cancer in Relation to Tumor Morphology and Endocrine Therapy

1978 ◽  
Vol 64 (5) ◽  
pp. 495-506 ◽  
Author(s):  
Zygmunt Paszko ◽  
Halina Padzik ◽  
Maria Dabska ◽  
Feliksa Pienkowska
Keyword(s):  
Breast Cancer ◽  
Endocrine Therapy ◽  
Human Breast Cancer ◽  
Tumor Tissue ◽  
Human Breast ◽  
Histological Grading ◽  
Er Positive ◽  
Estrogen Binding ◽  
Selection Of Patients ◽  
Selection Of

The presence of estrogen receptors (ER) was determined in 111 human breast cancer specimens. In 61 % of the tumors, specific estrogen binding was found and in 39 % of the tumors ER was absent. In 69 tumors no correlation was found between the histological grading of the tumor and the level of ER. The values of ER in tumors from patients over 50 years of age were usually much higher than those for patients under 50 years of age. Different methods of endocrine therapy were applied in 20 patients. In 10 of 15 patients with ER positive tumors, endocrine therapy resulted in remission. Only 1 of 5 patients with ER negative tumors responded with remission. It is concluded that estimation of ER in tumor tissue is helpful in the selection of patients for endocrine therapy.

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