Evaluation of clinical activity of acromegaly by observation of the diurnal variation of serum inorganic phosphate

Metabolism ◽  
1968 ◽  
Vol 17 (11) ◽  
pp. 966-976 ◽  
Author(s):  
Donald E. McMillan ◽  
John J. Deller ◽  
Gerold M. Grodsky ◽  
Peter H. Forsham
Keyword(s):  
Diurnal Variation ◽  
Inorganic Phosphate ◽  
Clinical Activity ◽  
Serum Inorganic Phosphate

Diabetes, Diabetic Complications, and Phosphate Toxicity: A Scoping Review

2020 ◽  
Vol 16 (7) ◽  
pp. 674-689 ◽  
Author(s):  
Ronald B. Brown
Keyword(s):  
Scoping Review ◽  
Diabetic Complications ◽  
Inorganic Phosphate ◽  
Dietary Intervention ◽  
Neuronal Degeneration ◽  
Ectopic Calcification ◽  
Treatment And Prevention ◽  
Research Findings ◽  
Serum Inorganic Phosphate ◽  
Prevention Of Diabetes

This article presents a scoping review and synthesis of research findings investigating the toxic cellular accumulation of dysregulated inorganic phosphate—phosphate toxicity—as a pathophysiological determinant of diabetes and diabetic complications. Phosphorus, an essential micronutrient, is closely linked to the cellular metabolism of glucose for energy production, and serum inorganic phosphate is often transported into cells along with glucose during insulin therapy. Mitochondrial dysfunction and apoptosis, endoplasmic reticulum stress, neuronal degeneration, and pancreatic cancer are associated with dysregulated levels of phosphate in diabetes. Ectopic calcification involving deposition of calcium-phosphate crystals is prevalent throughout diabetic complications, including vascular calcification, nephropathy, retinopathy, and bone disorders. A low-glycemic, low-phosphate dietary intervention is proposed for further investigations in the treatment and prevention of diabetes and related diabetic pathologies.

scholarly journals Biochemical Bone Markers for Early Detection of Osteopaenia of Prematurity

2017 ◽  
Vol 42 (3) ◽  
pp. 104-110
Author(s):  
Ismat Jahan ◽  
MA Mannan ◽  
Sanjoy Kumer Dey ◽  
Sadeka Choudhury Moni ◽  
Mohammod Shahidullah
Keyword(s):  
Early Detection ◽  
Premature Infants ◽  
Biochemical Markers ◽  
Inorganic Phosphate ◽  
Neonatal Intensive Care ◽  
Serum Alkaline Phosphatase ◽  
Growth Failure ◽  
Area Under Roc Curve ◽  
Serum Inorganic Phosphate ◽  
Medical University

Osteopaenia of prematurity (OOP) imposes the risk of fractures and growth failure to premature infants. Studies have investigated the validity of biochemical markers of osteopaenia but till date it is not established. So, this study was intended to examine the diagnostic performance of biochemical markers in early detection of osteopaenia of prematurity. This prospective study was conducted in the Neonatal Intensive Care Unit (NICU), Department of Neonatology, Bangabandhu Sheikh Mujib Medical University during June 2013 to February 2014. A total of 100 premature infants with gestational age ? 34 weeks were consecutively included over 9 months period. Serum alkaline phosphatase, serum calcium and serum inorganic phosphates were measured from 1 week of chronological age until corrected term age. At corrected term age, radiologic examination was done for the assessment of osteopaenia. Of the enrolled infants, 36/78 (46%) developed radiological evidence of osteopaenia. Serum inorganic phosphate level was significantly less in osteopaenic infants than non-osteopaenic infants throughout first two months of life (p <0.001). The area under ROC curve for serum inorganic phosphate was 85% (p = 0.001). If the cut off value of serum inorganic phosphate was set at 3.6 mg/dl, then a sensitivity of 86% and a specificity of 49% were obtained. Low serum inorganic phosphate at 3 weeks of life can be used as a marker for early detection of osteopaenia of prematurity. 

scholarly journals Association of serum inorganic phosphate with sex steroid hormones and vitamin D in a nationally representative sample of men

Andrology ◽  
2014 ◽  
Vol 2 (6) ◽  
pp. 967-976 ◽  
Author(s):  
W. Wulaningsih ◽  
M. Van Hemelrijck ◽  
K. Michaelsson ◽  
N. Kanarek ◽  
W. G. Nelson ◽  
...  
Keyword(s):  
Vitamin D ◽  
Steroid Hormones ◽  
Representative Sample ◽  
Inorganic Phosphate ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Nationally Representative ◽  
Serum Inorganic Phosphate

NATURE OF THE ACTION OF INSULIN ON THE LEVEL OF SERUM INORGANIC PHOSPHATE

1949 ◽  
Vol 159 (1) ◽  
pp. 107-110 ◽  
Author(s):  
Rachmiel Levine ◽  
S. D. Loube ◽  
Harry F. Weisberg
Keyword(s):  
Inorganic Phosphate ◽  
Serum Inorganic Phosphate

Characteristics of Monoclonal Immunoglobulins That Interfere with Serum Inorganic Phosphate Measurement

1994 ◽  
Vol 31 (3) ◽  
pp. 249-254 ◽  
Author(s):  
Shirley A Bowles ◽  
R Campbell Tait ◽  
Stephen G Jefferson ◽  
Maria H Gilleece ◽  
Mansel R Haeney
Keyword(s):  
Light Chain ◽  
Inorganic Phosphate ◽  
Immunoglobulin M ◽  
Clinical Implications ◽  
Igg Subclass ◽  
Light Chain Type ◽  
Monoclonal Immunoglobulins ◽  
Serum Inorganic Phosphate ◽  
Chain Type ◽  
Effect Of Light

The measurement of inorganic phosphate using an unmodified acid/molybdate assay is known to be subject to interference when paraproteinaemia exists. This phenomenon, due to precipitation in the reaction mixture, is not common to all paraproteins. We studied sera from 35 patients to determine whether interference in the assay was related to particular electrophysical characteristics of the paraproteins. There were spuriously elevated phosphate concentrations in 48·6% of the sera assayed. This could not be related to a direct effect of light chain type, electrical charge or IgG subclass. No IgA paraproteins were found to cause interference but there were immunoglobulin G (IgG) and immunoglobulin M (IgM) paraproteins in both the ‘interfering’ and ‘non-interfering’ groups. The median paraprotein concentration was similar in both groups but, where interference occurred, the degree increased in line with the paraprotein concentration. Although it does not seem possible to predict which samples will cause interference, it is important that the clinical implications of this problem are appreciated.

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