New natural products and their potent synthetic analogues: potentiators and antagonists of receptor operated ion channels

Toxicon ◽  
1994 ◽  
Vol 32 (3) ◽  
pp. 244-245
Keyword(s):  
Natural Products ◽  
Ion Channels ◽  
Synthetic Analogues

A Synthetic Route to N-methylpyrrole Containing Polyamide/Peptide Conjugate

2005 ◽  
Vol 2005 (4) ◽  
pp. 254-256 ◽  
Author(s):  
Yong Ye ◽  
Ming-Yu Niu ◽  
Qiang Yin ◽  
Li-feng Cao ◽  
Yu-Fen Zhao
Keyword(s):  
Natural Products ◽  
Plasmid Dna ◽  
Synthetic Route ◽  
Synthetic Analogues ◽  
Peptide Conjugates ◽  
H Nmr

A N-methylpyrrole containing polyamide/peptide conjugates which are synthetic analogues of natural products with DNA affinity was synthesised. It can efficiently hydrolyse PUC19 plasmid DNA. The structure of these compound was confirmed by 1H NMR, MS and IR.

scholarly journals Drug Discovery on Natural Products: From Ion Channels to nAChRs, from Nature to Libraries, from Analytics to Assays

2019 ◽  
Vol 24 (3) ◽  
pp. 362-385 ◽  
Author(s):  
Reka A. Otvos ◽  
Kristina B. M. Still ◽  
Govert W. Somsen ◽  
August B. Smit ◽  
Jeroen Kool
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Ion Channels ◽  
Ion Channel ◽  
Bioactive Compounds ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Drug Targets ◽  
Α7 Nachr ◽  
Analytical Approaches

Natural extracts are complex mixtures that may be rich in useful bioactive compounds and therefore are attractive sources for new leads in drug discovery. This review describes drug discovery from natural products and in explaining this process puts the focus on ion-channel drug discovery. In particular, the identification of bioactives from natural products targeting nicotinic acetylcholine receptors (nAChRs) and serotonin type 3 receptors (5-HT3Rs) is discussed. The review is divided into three parts: “Targets,” “Sources,” and “Approaches.” The “Targets” part will discuss the importance of ion-channel drug targets in general, and the α7-nAChR and 5-HT3Rs in particular. The “Sources” part will discuss the relevance for drug discovery of finding bioactive compounds from various natural sources such as venoms and plant extracts. The “Approaches” part will give an overview of classical and new analytical approaches that are used for the identification of new bioactive compounds with the focus on targeting ion channels. In addition, a selected overview is given of traditional venom-based drug discovery approaches and of diverse hyphenated analytical systems used for screening complex bioactive mixtures including venoms.

Beyond Natural Products: Synthetic Analogues of Bryostatin 1

2007 ◽  
pp. 125-162 ◽  
Author(s):  
Paul A. Wender ◽  
Jeremy L. Baryza ◽  
Michael K. Hilinski ◽  
Joshua C. Horan ◽  
Cindy Kan ◽  
...  
Keyword(s):  
Natural Products ◽  
Bryostatin 1 ◽  
Synthetic Analogues

Contributions of natural products to ion channel pharmacology

2020 ◽  
Vol 37 (5) ◽  
pp. 703-716
Author(s):  
Saumya Bajaj ◽  
Seow Theng Ong ◽  
K. George Chandy
Keyword(s):  
Natural Products ◽  
Ion Channels ◽  
Membrane Proteins ◽  
Ion Channel ◽  
Excitable Cells

Natural products harnessed from the diverse universe of compounds within the bioenvironment are being used to modulate ion channels, a vast super-family of membrane proteins that play critical physiological roles in excitable and non-excitable cells.

Natural Products and some semi-synthetic analogues as potential TRPV1 Ligands for attenuating Neuropathic pain

2021 ◽  
Vol 22 ◽  
Author(s):  
Gaurav Naik ◽  
Ankit Uniyal ◽  
Deepak Chouhan ◽  
Vinod Tiwari ◽  
Alakh Sahu
Keyword(s):  
Quality Of Life ◽  
Natural Products ◽  
Neuropathic Pain ◽  
Drug Discovery ◽  
Emotional Experience ◽  
Synthetic Analogues ◽  
Trpv1 Channels ◽  
Trp Receptors ◽  
Central Level

: Natural products and leads inspired by them have acted as a probe for successful drug discovery for many decades. Pain is an obnoxious sensory and emotional experience associated with potential tissue damage. It affects the quality of life of patients to a great extent. Despite the availability of several agents targeting TRP receptors, none of them can proficiently alleviate neuropathic pain. TRPV1 is a prospective target for treating neuropathic pain as it is recognized to modulate the pain circuitry at the periphery and central level. In this review, we have discussed several natural molecules (such as Capsaicinoids, capsinoids, Piperine, Eugenol, Scutigeral, Ginsenosides, Cinnamaldehyde, Camphor, Shogaol, Gingerols, Zingerone, Allicin, Evodiamine, Allylisothiocyanate, Cannabidiol, Ricinoleic acid, Isovelleral, Capsazepine, Thapsigargin, Pellitorine, Yohimbine, Curcumin) and some semi-synthetic analogues that activate TRPV1 channels, and can be further harnessed consequently for the treatment of neuropathic pain.

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