The presence of the past: Male violence in the family

Background: Morus alba Linn. commonly known as white mulberry, belongs to the family Moraceae, is a promising traditional medicine. In Asia, besides its use in the preparation of delicacies, every part of this plant is utilized in traditional medicine. Over the past decade, studies related to identification and isolation of biologically active compounds, with flavonoids as the major class of phytoconstituents, from this plant has been reported. These phytoconstituents are not only found to be beneficial for the maintenance of general health but also are associated with a range of potential pharmacological activities such as antioxidant, anti-inflammatory, anti-diabetic, anticancer, hepatoprotective, cardioprotective, neuroprotective to name a few. Objective: This review aims to provide upgraded and comprehensive information regarding the phytochemical, ethnomedicinal use and pharmacological profile of the plant Morus alba Linn. Method: The significant information has been collected through various database viz. PubMed, Scopus, Web of Science, Science Direct based on the recent findings, using different terms of Morus alba. Results: The outcome of the study suggests that Morus alba is a multifunctional plant numerous phytochemicals, and possess a range of pharmacological activities. Conclusion: The data assembled on Morus alba will be beneficial to trigger research in various fields of pharmaceutical and allied science to explore the medicinal importance of this unique plant.

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Factor X Deficiency Due to a Compound Heterozygosis Between a New Mutation (Gla72Asp) in Exon 2 and an Already Known one (Gly154Arg) in Exon 5: Factor X Mar Del Plata1)

Cardiovascular & Haematological Disorders - Drug Targets ◽

10.2174/1871529x19666181212103944 ◽

2019 ◽

Vol 19 (2) ◽

pp. 169-173

Author(s):

Antonio Girolami ◽

Diana Noemi Garcia de Paoletti ◽

Marcelo Leonardo Nenkies ◽

Silvia Ferrari ◽

Hugo Guglielmone

Keyword(s):

Bleeding Tendency ◽

Bleeding Disorders ◽

Factor X ◽

Substitution Therapy ◽

New Mutation ◽

Exon 2 ◽

The Third ◽

The Past ◽

Factor X Deficiency ◽

The Family

Background: Investigation of rare bleeding disorders in Latin-America. Objective: The report of a new case of FX deficiency due to a compound heterozygosis. Methods: Accepted clotting procedures were used. Sequencing of DNA was carried out by means of Applied Biosystems Instruments. Results: A compound heterozygote due to the association of a new mutation (Gla72Asp) with an already known mutation (Gly154Arg) of the FX gene is reported. The proposita is a 38 year old female who had a moderate bleeding tendency (menorrhagia, epistaxis, easy bruising). The proposita has never received substitution therapy but in the occasion of a uterine biopsy. The mother was asymptomatic but was a heterozygote for the new mutation. The father was asymptomatic but had deserted the family and could not be investigated. After this abandonment the mother of the proposita re-married with an asymptomatic man and she gave birth to a son who was asymptomatic but was also heterozygous for the new mutation (Gla72Asp). As a consequence it has to be assumed that the first husband of the mother of the proposita was heterozygous for the known mutation (Gly154Arg). Conclusion: This is the third case of a new mutation in the FX gene reported, during the past few years, in Argentina.

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Adhesion GPCRs in Glioblastoma

Neuro-Oncology Advances ◽

10.1093/noajnl/vdab046 ◽

2021 ◽

Author(s):

Gabriele Stephan ◽

Niklas Ravn-Boess ◽

Dimitris G Placantonakis

Keyword(s):

G Protein ◽

G Protein Coupled Receptors ◽

The Past ◽

Novel Treatment ◽

The Family ◽

Health And Disease ◽

Basic Biology ◽

G Protein Coupled ◽

Potential Use ◽

Receptor Family

Abstract Members of the adhesion family of G protein-coupled receptors (GPCRs) have received attention for their roles in health and disease, including cancer. Over the past decade, several members of the family have been implicated in the pathogenesis of glioblastoma. Here, we discuss the basic biology of adhesion GPCRs and review in detail specific members of the receptor family with known functions in glioblastoma. Finally, we discuss the potential use of adhesion GPCRs as novel treatment targets in neuro-oncology.

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Police, Social Work and Medical Responses to Battered Women

The Sociological Review ◽

10.1111/j.1467-954x.1983.tb00099.x ◽

1983 ◽

Vol 31 (1_suppl) ◽

pp. 109-123

Author(s):

Norman Johnson

Keyword(s):

Child Care ◽

Social Work ◽

Social Workers ◽

Battered Women ◽

Marital Violence ◽

Male Violence ◽

Paramedical Personnel ◽

The Family ◽

Seeking Help

Battered women frequently experience difficulties in seeking help from formal sources. They do not always know what services are available and they may be deterred by feelings of embarrassment, shame and even guilt. They may also fear reprisals. A further problem is that services are poorly co-ordinated. This paper examines the response of the three agencies most frequently approached by battered women seeking help. The police, social workers and medical and paramedical personnel reveal the same or similar attitudes towards marital violence and the problem is either ignored or redefined (usually in terms of child care). There is a marked reluctance on the part of all practitioners to become involved in cases of marital violence which they see as peripheral to their main concerns. The privacy of the family and of marriage is constantly stressed and women are viewed primarily as wives and mothers. When practitioners do become involved, therefore, the emphasis is on reconciliation rather than firm action. This response has the effect of trivializing the problems, and the legitimacy of male violence as a means of controlling women remains largely unchallenged. It is small wonder that battered women frequently express dissatisfaction with the services concerned.

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Sixty Years with the Chrysobalanaceae

The Botanical Review ◽

10.1007/s12229-020-09234-y ◽

2020 ◽

Author(s):

Ghillean T. Prance

Keyword(s):

Economic Botany ◽

Field Studies ◽

Molecular Evidence ◽

New Techniques ◽

Conservation Ecology ◽

The Past ◽

New Findings ◽

The Family ◽

Molecular Studies ◽

Economic Use

AbstractA review is given of the studies of Ghillean Prance and associates on the Chrysobalanaceae over the past sixty years. This has focussed on defining the generic boundaries in the family and on monographic work with a worldwide approach to this pantropical family. The importance of field studies for work on monographs and Floras is emphasized. Monographs are still the basis for much work on conservation, ecology and economic botany and are needed as a foundation for molecular studies. The importance of being open to experimenting with new techniques and as a result being willing to change the taxonomy in accordance with new findings is demonstrated and emphasized. The twelve genera of the Chrysobalanaceae at the beginning of this career-long study have now increased to twenty-eight in order to present a much better monophyletic and evolutionary arrangement based on recent molecular evidence. In particular it was necessary to divide and rearrange the originally large genera Parinari and Licania into a number of smaller segregate genera. All known species were included in a worldwide monograph published in 2003. A brief review of the economic use for the family is given.

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Enduring Cell Lines: Parents’ Experiences of Postmortem Tumor Banking in Childhood Cancer

Journal of Family Nursing ◽

10.1177/10748407211001431 ◽

2021 ◽

pp. 107484072110014

Author(s):

Nancy J. Moules ◽

Catherine M. Laing ◽

Wendy Pelletier ◽

Gregory M. T. Guilcher ◽

Jennifer A. Chan

Keyword(s):

Childhood Cancer ◽

Pediatric Oncology ◽

Common Factors ◽

Living Cells ◽

The Past ◽

The Family ◽

Deceased Donors ◽

Cure Rates ◽

The Impact ◽

Parents Experiences

While cure rates in pediatric oncology have improved over the past 30 years, childhood cancer remains the second leading cause of death in children aged 1 to 14. Developing therapies often require using cancerous tissues, which may come from deceased donors. Tumor banks collect, store, and distribute these donated samples. While tumor banking is more common, factors that contribute to parents’ decision and the impact of it on the family are not well understood. The purpose of this hermeneutic study was to understand the meaning and impact of tumor banking for parents of children who have died from cancer. Findings suggest that parents donating their child’s tumors unexpectedly found a sense of meaning in their loss. They also found a legacy of their child’s life; the living cells in some ways assisted the parents with grief. Aspects of this sensitive conversation and decision are discussed from the perspective of the parents’ experiences.

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