Fate of bioresorbable poly(lactic acid) microbeads implanted in artificial bone defects for cortical bone augmentation in dog mandible

Biomaterials ◽  
1993 ◽  
Vol 14 (1) ◽  
pp. 44-50 ◽  
Author(s):  
K. Anselme ◽  
B. Flautre ◽  
P. Hardouin ◽  
M. Chanavaz ◽  
C. Ustariz ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Cortical Bone ◽  
Bone Defects ◽  
Poly Lactic Acid ◽  
Bone Augmentation ◽  
Artificial Bone

scholarly journals Evaluation of a poly(lactic-acid) scaffold filled with poly(lactide-co-glycolide)/hydroxyapatite nanofibres for reconstruction of a segmental bone defect in a canine model

2019 ◽  
Vol 64 (No. 12) ◽  
pp. 531-538
Author(s):  
JW Yun ◽  
SY Heo ◽  
MH Lee ◽  
HB Lee
Keyword(s):  
Lactic Acid ◽  
Bone Defect ◽  
Bone Defects ◽  
Bone Morphogenetic Protein 2 ◽  
Poly Lactic Acid ◽  
Micro Computed Tomography ◽  
Bone Parameters ◽  
3D Printed ◽  
Group 3 ◽  
Group 2

Critical-sized bone defects are a difficult problem in both human and veterinary medicine. To address this issue, synthetic graft materials have been garnering attention. Abundant in vitro studies have proven the possibilities of poly(lactic-acid) (PLA) scaffolds and poly(lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) nanofibres for treating bone defects. The present study aimed at conducting an in vivo assessment of the biological performance of a three dimensional (3D)-printed PLA scaffold filled with a PLGA/HAp nanofibrous scaffold to estimate its potential applications in bone defect reconstruction surgery. Defects were created in a 20 mm-long region of the radius bone. The defects created on the right side in six Beagle dogs (n = 6) were left untreated (Group 1). The defects on the left side (n = 6) were filled with 3D-printed PLA scaffolds incorporated with PLGA/Hap nanofibres with gelatine (Group 2). The other six Beagle dog defects were made bilaterally (n = 12) and filled with the same material as that used in Group 2 along with recombinant bone morphogenetic protein 2 (rhBMP-2) (Group 3). Both the radiological and histological examinations were performed for observing the reaction of the scaffold and the bone. Micro-computed tomography (CT) was utilised for the evaluation of the bone parameters 20 weeks after the experiment. The radiological and histological results revealed that the scaffold was biodegradable and was replaced by new bone tissue. The micro-CT revealed that the bone parameters were significantly (P < 0.05) increased in Group 3. Based on these results, our study serves as a foundation for future studies on bone defect treatment using synthetic polymeric scaffolds.

scholarly journals Bone augmentation by octacalcium phosphate and collagen composite coated with poly‐lactic acid cage

2020 ◽  
Vol 6 (4) ◽  
pp. 391-399
Author(s):  
Toshiki Yanagisawa ◽  
Ayato Yasuda ◽  
Ria I. Makkonen ◽  
Shinji Kamakura
Keyword(s):  
Lactic Acid ◽  
Octacalcium Phosphate ◽  
Poly Lactic Acid ◽  
Bone Augmentation

Electrical Properties of Heat-Treated Poly-Lactic Acid

2011 ◽  
Vol 131 (5) ◽  
pp. 395-400 ◽  
Author(s):  
Toru Oi ◽  
Katsuyoshi Shinyama ◽  
Shigetaka Fujita
Keyword(s):  
Lactic Acid ◽  
Electrical Properties ◽  
Poly Lactic Acid ◽  
Heat Treated

Dielectric Breakdown Properties of Poly-Lactic Acid with Spherulites Growth

2014 ◽  
Vol 134 (4) ◽  
pp. 237-242
Author(s):  
Naru Matsugasaki ◽  
Katsuyoshi Shinyama ◽  
Shigetaka Fujita
Keyword(s):  
Lactic Acid ◽  
Dielectric Breakdown ◽  
Poly Lactic Acid

Characterizing Attapulgite-Reinforced Nanocomposites of Poly(lactic acid)

2020 ◽  
Vol 62 (6) ◽  
pp. 732-743
Author(s):  
Chi-Hui Tsou ◽  
Jipeng Guo ◽  
Ji-Ang Lei ◽  
Manuel Reyes De Guzman ◽  
Maw-Cherng Suen
Keyword(s):  
Lactic Acid ◽  
Poly Lactic Acid

Effect of Polyethylene Glycol in Nanocellulose/PLA Composites

2019 ◽  
Vol 821 ◽  
pp. 89-95
Author(s):  
Wanasorn Somphol ◽  
Thipjak Na Lampang ◽  
Paweena Prapainainar ◽  
Pongdhorn Sae-Oui ◽  
Surapich Loykulnant ◽  
...  
Keyword(s):  
Tensile Strength ◽  
Lactic Acid ◽  
Polyethylene Glycol ◽  
Aspect Ratio ◽  
Mechanical Performance ◽  
Tensile Modulus ◽  
Poly Lactic Acid ◽  
Solvent Casting ◽  
Casting Method ◽  
Mediated Oxidation

Poly (lactic acid) or PLA was reinforced by nanocellulose and polyethylene glycol (PEG), which were introduced into PLA matrix from 0 to 3 wt.% to enhance compatibility and strength of the PLA. The nanocellulose was prepared by TEMPO-mediated oxidation from microcrystalline cellulose (MCC) powder and characterized by TEM, AFM, and XRD to reveal rod-like shaped nanocellulose with nanosized dimensions, high aspect ratio and high crystallinity. Films of nanocellulose/PEG/PLA nanocomposites were prepared by solvent casting method to evaluate the mechanical performance. It was found that the addition of PEG in nanocellulose-containing PLA films resulted in an increase in tensile modulus with only 1 wt% of PEG, where higher PEG concentrations negatively impacted the tensile strength. Furthermore, the tensile strength and modulus of nanocellulose/PEG/PLA nanocomposites were higher than the PLA/PEG composites due to the existence of nanocellulose chains. Visual traces of crazing were detailed to describe the deformation mechanism.

scholarly journals Poly(lactic acid)—Mass production, processing, industrial applications, and end of life

2016 ◽  
Vol 107 ◽  
pp. 333-366 ◽  
Author(s):  
E. Castro-Aguirre ◽  
F. Iñiguez-Franco ◽  
H. Samsudin ◽  
X. Fang ◽  
R. Auras
Keyword(s):  
Lactic Acid ◽  
End Of Life ◽  
Mass Production ◽  
Industrial Applications ◽  
Poly Lactic Acid
Sign in / Sign up

Export Citation Format

Share Document