The role of vitamin D status in reduced risk of hip fracture

1992 ◽  
Vol 17 ◽  
pp. 179
Author(s):  
S. Birge ◽  
S. Price ◽  
C. Arfken ◽  
J.P. Miller ◽  
W. Peck ◽  
...  
2021 ◽  
pp. bmjmilitary-2020-001686
Author(s):  
Iain T Parsons ◽  
R M Gifford ◽  
M J Stacey ◽  
L E Lamb ◽  
M K O'Shea ◽  
...  

For most individuals residing in Northwestern Europe, maintaining replete vitamin D status throughout the year is unlikely without vitamin D supplementation and deficiency remains common. Military studies have investigated the association with vitamin D status, and subsequent supplementation, with the risk of stress fractures particularly during recruit training. The expression of nuclear vitamin D receptors and vitamin D metabolic enzymes in immune cells additionally provides a rationale for the potential role of vitamin D in maintaining immune homeostasis. One particular area of interest has been in the prevention of acute respiratory tract infections (ARTIs). The aims of this review were to consider the evidence of vitamin D supplementation in military populations in the prevention of ARTIs, including SARS-CoV-2 infection and consequent COVID-19 illness. The occupational/organisational importance of reducing transmission of SARS-CoV-2, especially where infected young adults may be asymptomatic, presymptomatic or paucisymptomatic, is also discussed.


Nutrients ◽  
2011 ◽  
Vol 3 (12) ◽  
pp. 1023-1041 ◽  
Author(s):  
Louise O’Mahony ◽  
Magdalena Stepien ◽  
Michael J. Gibney ◽  
Anne P. Nugent ◽  
Lorraine Brennan

2017 ◽  
Vol 3 (1i) ◽  
pp. 564-567
Author(s):  
Efstathios Drampalos ◽  
Lazaros Oikonomidis ◽  
Jeremy Oakley ◽  
Ioannis Michos ◽  
fstathios Chronopoulos

2020 ◽  
Author(s):  
Zhenzhen Wan ◽  
Jingyu Guo ◽  
An Pan ◽  
Chen Chen ◽  
Liegang Liu ◽  
...  

<b>Objective: </b>The evidence regarding vitamin D status and mortality among diabetes is scarce. This study aimed to examine the association of serum 25-hydroxyvitamin D [25(OH)D] concentrations with all-cause and cause-specific mortality among adults with <a>diabetes mellitus</a>. <p><b>Research Design and Methods: </b>This study included 6329 adults with diabetes from the Third National Health and Nutrition Examination Survey (NHANES III) and NHANES 2001-2014. Death outcomes were ascertained by linkage to National Death Index records through 31 December 2015. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence (CIs) for mortality from all causes, cardiovascular disease (CVD), and cancer.</p> <p><b>Results:</b> The weighted mean (95% CI) level of serum 25(OH)D was 57.7 (56.6, 58.8) nmol/L, and 46.6% had deficient vitamin D (<50 nmol/L [20 ng/mL]). <a>Higher </a>serum 25(OH)D levels were significantly associated with lower levels of glucose, insulin, HOMA-IR, HbA1c, blood lipids, and C-reactive protein at baseline (all <i>P</i><sub>trend</sub><0.05). During 55126 person-years of follow-up, 2056 deaths were documented, including 605 CVD deaths and 309 cancer deaths. <a>After multivariate adjustment, higher </a>serum 25(OH)D levels were significantly and linearly associated with lower all-cause and CVD mortality: there was a 31% reduced risk of all-cause mortality and a 38% reduced risk of CVD mortality per one unit increment in natural log-transformed 25(OH)D (both <i>P</i><0.001). Compared with participants with 25(OH)D <25 nmol/L, the multivariate-adjusted HRs and 95% CI for participants with 25(OH)D >75 nmol/L were 0.59 (0.43, 0.83) for all-cause mortality (<i>P</i><sub>trend</sub>=0.003), 0.50 (0.29, 0.86) for CVD mortality (<i>P</i><sub>trend</sub>=0.02), and 0.49 (0.23, 1.04) for cancer mortality (<i>P</i><sub>trend</sub>=0.12). </p> <p><b>Conclusions: </b>In a nationally representative sample of US adults with diabetes, higher serum 25(OH)D levels were significantly associated with lower all-cause and CVD mortality. These findings suggest that maintaining adequate vitamin D status may lower mortality risk in individuals with diabetes.</p>


Author(s):  
Brice Kouakou Bla ◽  
Alexis Gnogbo Bahi ◽  
Juliana Mensah-Akaki ◽  
Souleymane Méité ◽  
Françis Adou Yapo ◽  
...  

Aims: The pathophysiology of Plasmodium falciparum infection is most often associated with anemia and immune deficiency. Given the important role of vitamin D in the synthesis of hemoglobin and in the stimulation of the immune system, it would be essential to assess the vitamin D status of patients with malaria in order to improve the quality of treatment management. Methodology: A thick drop and a blood smear were used to determine parasite density and parasite species respectively. The complete blood count was performed using an automated analyzer labelled Sysmex XN 1000i. Biochemical parameters such as calcium and phosphorus were determined using the Cobas C311 Hitachi. The Vidas was used to determine the concentrations of 25 (OH) -vitamin D. Results: The results showed a decrease in 25 (OH) -vitamin D concentrations in relation to the parasite density and anemia observed in patients with uncomplicated malaria. Conclusion: Vitamin D status in patients with uncomplicated malaria could represent an essential biomarker in the monitoring of antimalarial treatment.


2012 ◽  
Vol 142 (3) ◽  
pp. 482-489 ◽  
Author(s):  
Ashwin N. Ananthakrishnan ◽  
Hamed Khalili ◽  
Leslie M. Higuchi ◽  
Ying Bao ◽  
Joshua R. Korzenik ◽  
...  

2014 ◽  
Vol 15 (4) ◽  
pp. S27
Author(s):  
M. Petrov ◽  
T. Glover ◽  
B. Goodin ◽  
L. Bradley ◽  
R. Fillingim

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3176
Author(s):  
Sharon M. Anderson ◽  
Andrea R. Thurman ◽  
Neelima Chandra ◽  
Suzanne S. Jackson ◽  
Susana Asin ◽  
...  

While vitamin D insufficiency is known to impact a multitude of health outcomes, including HIV-1, little is known about the role of vitamin D-mediated immune regulation in the female reproductive tract (FRT). We performed a pilot clinical study of 20 women with circulating 25(OH)D levels <62.5 nmol/L. Participants were randomized into either weekly or daily high-dose oral vitamin D supplementation groups. In addition to serum vitamin D levels, genital mucosal endpoints, including soluble mediators, immune cell populations, gene expression, and ex vivo HIV-1 infection, were assessed. While systemic vitamin D levels showed a significant increase following supplementation, these changes translated into modest effects on the cervicovaginal factors studied. Paradoxically, post-supplementation vitamin D levels were decreased in cervicovaginal fluids. Given the strong correlation between vitamin D status and HIV-1 infection and the widespread nature of vitamin D deficiency, further understanding of the role of vitamin D immunoregulation in the female reproductive tract is important.


Author(s):  
F. Ingstad ◽  
L. B. Solberg ◽  
L. Nordsletten ◽  
P. M. Thorsby ◽  
I. Hestnes ◽  
...  

2018 ◽  
Vol 4 (4) ◽  
pp. S15
Author(s):  
Hyun Uk Moon ◽  
Yong Jun Choi ◽  
Jung-Taek Kim ◽  
Ye-Yeon Won ◽  
Yoon-Sok Chung

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