Dramatic alterations in levels of polyunsaturated fatty acids of plasma and red blood cell phospholipids in cancer malnourished patients

1987 ◽  
Vol 6 ◽  
pp. 22
Author(s):  
C. Hooper ◽  
P. De Souto Barreto ◽  
M. Pahor ◽  
M. Weiner ◽  
B. Vellas

Significant research attention has focussed on the identification of nutraceutical agents for the prevention of cognitive decline as a natural means of cognitive preservation in the elderly. There is some evidence for a reduction of brain omega 3 polyunsaturated fatty acids (n-3 PUFAs) in normal aging and in Alzheimer’s disease. n-3 PUFAs exhibit anti-inflammatory and anti-amyloidogenic properties as well as being able to reduce tau phosphorylation. Many observational studies have demonstrated a link between n-3 PUFAs and cognitive aging, and some, but not all, randomized controlled trials have demonstrated a benefit of n-3 PUFA supplementation on cognition, particularly in those subjects with mild cognitive impairment. The identification of a biomarker that reflects n-3 PUFA intake over time and consequent tissue levels is required. In this narrative review we discuss the evidence associating red blood cell membrane n-3 PUFAs with cognitive function and structural brain changes associated with Alzheimer’s disease. Key words: Docosahexaenoic acid, omega 3 polyunsaturated fatty aci


2003 ◽  
Vol 52 (8) ◽  
pp. 397-406 ◽  
Author(s):  
Nakamichi WATANABE ◽  
Katsura FUNAYAMA ◽  
Fumiko KIMURA ◽  
Yasushi ENDO ◽  
Kenshiro FUJIMOTO ◽  
...  

2013 ◽  
Vol 207 (1-2) ◽  
pp. 1-12 ◽  
Author(s):  
Wendela P. Hoen ◽  
Jeroen G. Lijmer ◽  
Marinus Duran ◽  
Ronald J.A. Wanders ◽  
Nico J.M. van Beveren ◽  
...  

2009 ◽  
Vol 88 (1) ◽  
pp. 91-97 ◽  
Author(s):  
Anna R. Magnusardottir ◽  
Laufey Steingrimsdottir ◽  
Holmfridur Thorgeirsdottir ◽  
Arnar Hauksson ◽  
Gudrun V. Skuladottir

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