Treatment with dietary saturated fatty acids reduces endotoxemia, TNF? mRNA and collagen in experimental alcoholic liver disease *Dept. Pathol., N.E. Deaconess Hosp. and Harvard Med. Sch., Boston, MA and ?Dept. of Medicine, Cornell Med. Coll. and Strang Cancer Prev. Ctr., New York, NY

Hepatology ◽  
1995 ◽  
Vol 22 (4) ◽  
pp. A225
Keyword(s):  
Fatty Acids ◽  
New York ◽  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Saturated Fatty Acids ◽  
Dept Pathol

Dietary saturated fatty acids: A novel treatment for alcoholic liver disease

1995 ◽  
Vol 109 (2) ◽  
pp. 547-554 ◽  
Author(s):  
Amin A. Nanji ◽  
S.M. Hossein Sadrzadeh ◽  
Eun K. Yang ◽  
Franz Fogt ◽  
Mohsen Meydani ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Saturated Fatty Acids ◽  
Novel Treatment

Serum lipids and total fatty acids in chronic alcoholic liver disease at different stages of cell damage

1970 ◽  
Vol 48 (15) ◽  
pp. 949-950 ◽  
Author(s):  
A. Marzo ◽  
P. Ghirardi ◽  
D. Sardini ◽  
B. D. Prandini ◽  
A. Albertini
Keyword(s):  
Fatty Acids ◽  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Serum Lipids ◽  
Cell Damage ◽  
Chronic Alcoholic ◽  
Total Fatty Acids

scholarly journals Saturated Fatty Acids Promote Endoplasmic Reticulum Stress and Liver Injury in Rats with Hepatic Steatosis

Endocrinology ◽  
2006 ◽  
Vol 147 (2) ◽  
pp. 943-951 ◽  
Author(s):  
Dong Wang ◽  
Yuren Wei ◽  
Michael J. Pagliassotti
Keyword(s):  
Fatty Acids ◽  
Endoplasmic Reticulum ◽  
Liver Disease ◽  
Liver Injury ◽  
Endoplasmic Reticulum Stress ◽  
Hepatic Steatosis ◽  
Fatty Liver Disease ◽  
Saturated Fatty Acids ◽  
Nonalcoholic Fatty Liver ◽  
Steatotic Liver

Nonalcoholic fatty liver disease is a relatively new hepatic sequela of obesity and type 2 diabetes. The pathogenesis of liver injury and disease progression in nonalcoholic fatty liver disease, however, is poorly understood. The present study examined the hypothesis that the composition of fatty acids in the steatotic liver promotes liver injury. Using dietary models of hepatic steatosis characterized by similar accumulation of total triglyceride but different composition of fatty acids, we show that hepatic steatosis characterized by increased saturated fatty acids is associated with increased liver injury and markers of endoplasmic reticulum stress (e.g. X-box binding protein-1 mRNA splicing and glucose-regulated protein 78 expression). These changes preceded and/or occurred independently of obesity and differences in leptin, TNFα, insulin action, and mitochondrial function. In addition, hepatic steatosis characterized by increased saturated fatty acids reduced proliferative capacity in response to partial hepatectomy and increased liver injury in response to lipopolysaccharide. These data suggest that the composition of fatty acids in the steatotic liver is an important determinant of susceptibility to liver injury.

Sign in / Sign up

Export Citation Format

Share Document