Effects of cysteine and cystamine on the carbon tetrachloride induced decrease in arachidonic acid content of rat liver microsomal phospholipids

Toxicology ◽  
1981 ◽  
Vol 19 (1) ◽  
pp. 77-82 ◽  
Author(s):  
E.G.D. de Toranzo ◽  
A. Marzi ◽  
J.A. Castro
Author(s):  
R. Takahashi ◽  
D.F. Horrobin ◽  
Y. Watanabe ◽  
V. Kyte ◽  
V. Billard

1999 ◽  
Vol 45 ◽  
pp. 743-743
Author(s):  
C Agostoni ◽  
F Marangoni ◽  
A M Lammardo ◽  
A Gamboni ◽  
E D'Auria ◽  
...  

1999 ◽  
Vol 45 ◽  
pp. 743-743
Author(s):  
C Agostoni ◽  
F Marangoni ◽  
A M Lammardo ◽  
E Verduci ◽  
E Riva ◽  
...  

1992 ◽  
Vol 262 (3) ◽  
pp. R464-R471 ◽  
Author(s):  
T. Ohkubo ◽  
R. Jacob ◽  
H. Rupp

To define the effects of physical activity on vascular fatty acid composition and prostanoid generation, spontaneously hypertensive and normotensive rats were made to swim at 34-35 degrees C for 5-7 wk. Fatty acids were determined by gas chromatography and prostanoids by high-performance liquid chromatography and electrochemical detection. A characteristic feature of swimming rats was a markedly reduced linoleic acid content in the iliac artery and the aorta; in normotensive swimming rats stearic acid and arachidonic acid contents were increased. These changes could not be attributed to a heat loss during swimming or to depressed growth characteristics. A chemical sympathectomy using guanethidine (60 mg/kg body wt daily) did not prevent the alterations in fatty acid composition. A higher arachidonic acid content was correlated with an increased generation of 6-ketoprostaglandin F1 alpha in the aorta of untreated rats and sympathectomized rats. It is concluded that swimming can alter the vascular fatty acid composition in a manner which results in an increased potential for prostacyclin production.


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