Nuclear magnetic resonance (NMR) imaging of the brain in systemic lupus erythematosus

1984 ◽  
Vol 2 (2) ◽  
pp. 155-156
Author(s):  
M. Vermess ◽  
R.M. Bernstein ◽  
G.M. Bydder ◽  
R.E. Steiner ◽  
I.R. Young ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Lupus Erythematosus ◽  
Nmr Imaging ◽  
Systemic Lupus ◽  
The Brain ◽  
Nuclear Magnetic

Nuclear Magnetic Resonance (NMR) Imaging of the Brain in Systemic Lupus Erythematosus

1983 ◽  
Vol 7 (3) ◽  
pp. 461-467 ◽  
Author(s):  
M. Vermess ◽  
R. M. Bernstein ◽  
G. M. Bydder ◽  
R. E. Steiner ◽  
I. R. Young ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Lupus Erythematosus ◽  
Nmr Imaging ◽  
Systemic Lupus ◽  
The Brain ◽  
Nuclear Magnetic

Nuclear Magnetic Resonance Lipoprotein Subclasses and the APOE Genotype Influence Carotid Atherosclerosis in Patients with Systemic Lupus Erythematosus

2010 ◽  
Vol 37 (11) ◽  
pp. 2259-2267 ◽  
Author(s):  
MARTA GONZÀLEZ ◽  
JOSEP RIBALTA ◽  
GLÒRIA VIVES ◽  
SIMONA IFTIMIE ◽  
RAIMÓN FERRÉ ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Lupus Erythematosus ◽  
Carotid Atherosclerosis ◽  
Apoe Genotype ◽  
Density Lipoprotein ◽  
Systemic Lupus ◽  
Lipoprotein Subclasses ◽  
Nuclear Magnetic

Objective.Patients with systemic lupus erythematosus (SLE) have accelerated atherosclerosis. Since the conventional lipid profile (total plasma cholesterol, triglycerides, low and high density lipoprotein cholesterol) is not consistently altered in SLE, we hypothesized that investigation of lipoprotein subclasses would improve prediction of risk of atherosclerosis in these patients.Methods.As a quantitative index of atherosclerosis, we measured the carotid intima-media thickness (IMT) in 68 patients with SLE and related the atherosclerosis to a detailed lipoprotein profile generated using nuclear magnetic resonance (NMR). We measured the cholesterol transported by the pool of remnant lipoproteins (RLPc) and evaluated the modulatory effect of the APOE genotype on the lipoprotein subclass profile and atherosclerosis associated with SLE.Results.Circulating lipoprotein remnant particles [RLPc and intermediate density lipoprotein (IDL)] were positively correlated with IMT, and among them, the indicator that explained 20.2% of the variability in carotid atherosclerosis measured in these patients was IDL, as assessed by NMR. Carriers of the APOE2 allele were at increased risk due to a significant accumulation of IDL particles.Conclusion.Lipoprotein subclasses are more associated with subclinical atherosclerosis in patients with SLE than the lipid variables that are routinely measured. The IDL fraction, which is significantly modulated by the APOE genotype, is the most strongly, significantly, and positively correlated with IMT.

scholarly journals Magnetic resonance imaging of the brain and cerebral proton spectroscopy in patients with systemic lupus erythematosus

1997 ◽  
Vol 40 (1) ◽  
pp. 36-46 ◽  
Author(s):  
R. J. S. Chinn ◽  
I. D. Wilkinson ◽  
M. A. Hall-Craggs ◽  
M. N. J. Paley ◽  
E. Shortall ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Systemic Lupus Erythematosus ◽  
Magnetic Resonance ◽  
Lupus Erythematosus ◽  
Resonance Imaging ◽  
Proton Spectroscopy ◽  
Systemic Lupus ◽  
The Brain

Fluorine-19 Nuclear Magnetic Resonance Imaging and Spectroscopy of Sevoflurane Uptake, Distribution, and Elimination in Rat Brain

1995 ◽  
Vol 83 (4) ◽  
pp. 766-774. ◽  
Author(s):  
Yan Xu ◽  
Pei Tang ◽  
Weiguo Zhang ◽  
Leonard Firestone ◽  
Peter M. Winter
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Brain Tissue ◽  
19F Nmr ◽  
Nmr Imaging ◽  
General Anesthetic ◽  
Imaging Methods ◽  
Imaging And Spectroscopy ◽  
The Brain ◽  
Nuclear Magnetic

Background Determination of macroscopic and microscopic distribution of general anesthetics can facilitate identification of anatomic, cellular, and molecular loci of anesthetic action. Previous attempts to measure brain anesthetic distributions with fluorine-19 (19F) nuclear magnetic resonance (NMR) imaging were conducted at magnetic field strengths lower than 2 Tesla. All have produced only silhouettes of brain tissue. Difficulties intrinsic to NMR imaging of anesthetics include higher anesthetic solubility in extracranial tissues and the lower limits to spin-echo delay times that can be used in conventional NMR imaging methods. So far, such methods have been unable to capture rapidly decaying brain 19F NMR signals. Methods 19F NMR imaging and spectroscopy were conducted at 4.7 Tesla using a specially developed NMR probe and new imaging methods. With the new techniques, it was possible to observe directly the uptake, distribution, and elimination in brain of sevoflurane, a fluorinated general anesthetic with special advantages for NMR investigations. Results 19F NMR images, acquired at different times after sevoflurane administration, clearly showed the distribution of a fluorinated general anesthetic within the brain. Based on continuous transverse relaxation time measurements, sevoflurane signals could be separated into two components, attributable respectively to sevoflurane in a mobile or immobile microenvironment. During washin, there was a delayed accumulation of anesthetic in the mobile microenvironment. During washout, there was a rapid elimination from the immobile microenvironment. Conclusions At anesthetizing concentrations, sevoflurane distributes heterogeneously in the brain. Sevoflurane in the brain tissue contributes mostly to the immobile component of the 19F signal, whereas that in the surrounding adipose and muscle tissues contributes mostly to the mobile component. Imaging and spectroscopic results suggest that the immobile component of sevoflurane is associated with the general anesthetic effects of the agent.

Nuclear Magnetic Resonance (NMR): I. Imaging Biochemical Change

1985 ◽  
Vol 146 (1) ◽  
pp. 26-31 ◽  
Author(s):  
L. M. Eastwood ◽  
J. M. S. Hutchison ◽  
J. A. O. Besson
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Clinical Investigation ◽  
Biological Significance ◽  
Biochemical Change ◽  
Nmr Imaging ◽  
Functional Psychoses ◽  
The Individual ◽  
The Brain ◽  
Nuclear Magnetic

SummaryNuclear magnetic resonance (NMR) imaging of hydrogen in body water and fat is proving valuable in clinical investigation of the brain. An introduction to the technique and to the biological significance of the images is presented here. The ‘multi-parameter’ nature of these images is stressed, and the individual parameters described. NMR imaging may well be of value in investigating the pathology of organic and functional psychoses.

scholarly journals Non compacted cardiomyopathy as a cause of insufficiency cardiac in Systemic Lupus Erythematosus

2021 ◽  
pp. 33-36
Author(s):  
María Isabel Quaglia ◽  
Carla Gobbi ◽  
Carla Alonso ◽  
Yohana Tissera ◽  
Rosa Figueroa ◽  
...  
Keyword(s):  
Heart Failure ◽  
Systemic Lupus Erythematosus ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Lupus Erythematosus ◽  
Decompensated Heart Failure ◽  
Review Of The Literature ◽  
Systemic Lupus ◽  
Genetic Etiology ◽  
Myocardial Morphology

Non compacted cardiomyopathy (NCNC) frequently represents an abnormality of myocardial morphology associated with a genetic etiology, however, there are few descriptions of its association with autoimmune diseases. We present a review of the literature and the case of a lupus patient who was admitted with signs of decompensated heart failure with confirmation of VINC by echocardiography and cardiac nuclear magnetic resonance (C-MRI).

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