Glycosylated hemoglobins in sharks: Relevance to long-term blood glucose levels and erythrocyte survival

Author(s):  
A.I. Alayash ◽  
G. Godette ◽  
J. Bona Ventura ◽  
J. Arnold
2019 ◽  
Author(s):  
Rizky Asmaul Husnah

Diabetes mellitus is a chronic disease that lasts long term, where blood glucose levels pass within normal limits. Family is also one of the support systems that can be utilized in providing nursing services and management of patients with diabetes mellitus. Support and good family behavior can affect the compliance of patients with diabetes mellitus in treatment.


2015 ◽  
Vol 112 (4) ◽  
pp. 1226-1231 ◽  
Author(s):  
Yuanyuan Zhang ◽  
Fei Fang ◽  
Joseph L. Goldstein ◽  
Michael S. Brown ◽  
Tong-Jin Zhao

Plasma growth hormone (GH) and hepatic autophagy each have been reported to protect against hypoglycemia in the fasted state, but previous data have not linked the two. Here we demonstrate a connection using a mouse model of fasting in a fat-depleted state. Mice were subjected to 1 wk of 60% calorie restriction, causing them to lose nearly all body fat. They were then fasted for 23 h. During fasting, WT mice developed massive increases in plasma GH and a concomitant increase in hepatic autophagy, allowing them to maintain viable levels of blood glucose. In contrast, lethal hypoglycemia occurred in mice deficient in the GH secretagogue ghrelin as a result of knockout of the gene encoding ghrelin O-acyltransferase (GOAT), which catalyzes a required acylation of the peptide. Fasting fat-depleted Goat−/− mice showed a blunted increase in GH and a marked decrease in hepatic autophagy. Restoration of GH by infusion during the week of calorie restriction maintained autophagy in the Goat−/− mice and prevented lethal hypoglycemia. Acute injections of GH after 7 d of calorie restriction also restored hepatic autophagy, but failed to increase blood glucose, perhaps owing to ATP deficiency in the liver. These data indicate that GH stimulation of autophagy is necessary over the long term, but not sufficient over the short term to maintain blood glucose levels in fasted, fat-depleted mice.


2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Julia Schmolinsky ◽  
Thomas Kocher ◽  
Wolfgang Rathmann ◽  
Henry Völzke ◽  
Christiane Pink ◽  
...  

Abstract We estimated effects of diabetes mellitus and metabolic control on long-term change in coronal caries and restorative status using 11-year-follow-up data from the population-based Study of Health in Pomerania. Data of 3731 participants with baseline and 5- and 11-year follow-up information were included. Diabetes was defined via self-reported physician´s diagnosis or intake of glucose-lowering drugs or hemoglobin A1c (HbA1c) ≥6.5% or fasting blood glucose levels ≥11.1 mmol/l. The diabetes status was defined as no diabetes (HbA1c < 6.5% or non-fasting blood glucose <11.1 mmol/l), subjects with known or undetected diabetes mellitus and HbA1c ≤ 7% (well-controlled diabetes), and subjects with known or undetected diabetes mellitus and HbA1c > 7% (poorly-controlled diabetes). The caries status was clinically assessed using the half-mouth method and the Decayed Missing Filled Surfaces (DMFS) index and its component scores were determined. Covariate-adjusted linear mixed models were evaluated. Rates in change in DMFS were significantly higher in subjects with poorly-controlled diabetes compared to subjects without diabetes. Subjects with poorly- and well-controlled diabetes had significantly higher rates in change in Missing Surfaces (MS) compared to subjects without diabetes. For the DFS, rates in change were significantly lower for subjects with well-controlled diabetes and higher for subjects with poorly-controlled diabetes as compared to subjects without diabetes. Concordantly, all rates in change increased proportional to HbA1c levels. Effects were even more pronounced in subjects with diabetes duration of ≥5 years. Subjects with poorly-controlled diabetes are at higher risk for caries progression compared to subjects without diabetes, especially in case of longer disease duration.


2010 ◽  
Vol 7 (3) ◽  
pp. 387-389 ◽  
Author(s):  
Jian-You Guo ◽  
Chun-Chao Han ◽  
Yong-Mei Liu

Diabetes mellitus is accompanied by hormonal and neurochemical changes that can be associated with anxiety and depression. Both diabetes and depression negatively interact, in that depression leads to poor metabolic control and hyperglycemia exacerbates depression. We hypothesize one novel vanadium complex of vanadium-enrichedCordyceps sinensis(VECS), which is beneficial in preventing depression in diabetes, and influences the long-term course of glycemic control. Vanadium compounds have the ability to imitate the action of insulin, and this mimicry may have further favorable effects on the level of treatment satisfaction and mood.C. sinensishas an antidepressant-like activity, and attenuates the diabetes-induced increase in blood glucose concentrations. We suggest that the VECS may be a potential strategy for contemporary treatment of depression and diabetes through the co-effect ofC. sinensisand vanadium. The validity of the hypothesis can most simply be tested by examining blood glucose levels, and swimming and climbing behavior in streptozotocin-induced hyperglycemic rats.


2015 ◽  
Vol 1 (1) ◽  
pp. 10-15
Author(s):  
Sri Rahayu ◽  
Sri Rahayu ◽  
Siti Sundari ◽  
Erni Widiyani

Injectable is one of the most widely used contraceptives in Indonesia. Injectable contraceptive often causes the changes in blood glucose levels because it contains a steroid hormone with low anti-insulin. The use in the long term can even cause pancreatitis. Hormones in injectable contraceptive have opposite work against insulin. Insulin resistance causes pancreas to increasingly work harder to produce insulin. Over time the pancreas will not be able to function optimally and will have an impact on blood glucose levels. The objective of this study was to determine the relationship of the length of injectable contraceptive use to blood glucose levels among combined injectable acceptors. This study used cross sectional study design. The source of data was primary data with the respondents combined injectable acceptors in Privately Practising Midwife "E" at Purwosari Sub-district. The sampling technique was non probability sampling with a total sampling of 46 respondents who met the inclusion criteria. Data were analyzed using bivariate analysis with chi-square. In this study, 41% of women were found to have high glucose levels (>125mg/dl). A total of 53.8% of women who used combined injectable contraceptive more than two years had blood glucose levels over 125 mg / dl, but from the results of the analysis, it showed that the length of contraceptive use was not statistically significant with blood glucose levels (p value 0.095). Therefore, injectable contraceptive used in the long term must be taken into account.


2021 ◽  
Vol 7 (1) ◽  
pp. 27
Author(s):  
Muhammad Ryznar Faisal Nur Luqmani ◽  
Kristianningrum Dian Sofiana ◽  
Bagus Hermansyah

Increase in blood glucose levels can be caused by the long-term use of pesticides by farmers. This study aims to determine whether there is a correlation between the activity of cholinesterase as an indicator of exposure to pesticides and blood glucose of farmers in Mlokorejo Village, Jember Regency. The research method is observational-analytic with a cross-sectional study design. Data in the form of general characteristics of the sample were obtained through interviews, while the data of the activity of cholinesterase and blood glucose levels of farmers were obtained at the Biochemical Laboratory of the Faculty of Medicine, Jember University. The sample size of this study is 30 samples. All of the samples are having an increased activity of cholinesterase. Most of the samples are having normal blood glucose levels. Based on the results of statistical analysis using the Spearman correlation test (a= 0.05), it was concluded that there was no significant correlation between the two variables (p = 0,191). Keywords: blood glucose, cholinesterase, pesticides


2017 ◽  
Vol 29 (1) ◽  
pp. 135-142 ◽  
Author(s):  
NaNa Keum ◽  
Kyoung Hwa Ha ◽  
Ying Bao ◽  
Moon Jae Chung ◽  
Hyeon Chang Kim ◽  
...  

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