Gene expression of a novel protein homologous to the products of cell-cycle control and cell-fate determination genes in rat central nervous system

Cell diversity in the Drosophila central nervous system (CNS) is primarily generated by the invariant lineage of neural precursors called neuroblasts. We used an enhancer trap screen to identify the ming gene, which is transiently expressed in a subset of neuroblasts at reproducible points in their cell lineage (i.e. in neuroblast ‘sublineages’), suggesting that neuroblast identity can be altered during its cell lineage. ming encodes a predicted zinc finger protein and loss of ming function results in precise alterations in CNS gene expression, defects in axonogenesis and embryonic lethality. We propose that ming controls cell fate within neuroblast cell lineages.

Download Full-text

Underlying principles of cell fate determination during G1 phase of the mammalian cell cycle

Cell Cycle ◽

10.4161/cc.7.20.6853 ◽

2008 ◽

Vol 7 (20) ◽

pp. 3246-3257 ◽

Cited By ~ 26

Author(s):

Benjamin Pfeuty ◽

Thérèse David-Pfeuty ◽

Kunihiko Kaneko

Keyword(s):

Cell Cycle ◽

Cell Fate ◽

Mammalian Cell ◽

G1 Phase ◽

Cell Fate Determination ◽

Fate Determination ◽

Mammalian Cell Cycle

Download Full-text

A potential role for bone morphogenetic protein signalling in glial cell fate determination following adult central nervous system injury in vivo

European Journal of Neuroscience ◽

10.1111/j.1460-9568.2007.05940.x ◽

2007 ◽

Vol 26 (11) ◽

pp. 3024-3035 ◽

Cited By ~ 60

Author(s):

David W. Hampton ◽

Richard A. Asher ◽

Toru Kondo ◽

John D. Steeves ◽

Matt S. Ramer ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Bone Morphogenetic Protein ◽

Glial Cell ◽

Cell Fate ◽

Potential Role ◽

Cell Fate Determination ◽

Bone Morphogenetic Protein Signalling ◽

Morphogenetic Protein

Download Full-text

Novel insights into cell cycle regulation of cell fate determination

Journal of Zhejiang University SCIENCE B ◽

10.1631/jzus.b1900197 ◽

2019 ◽

Vol 20 (6) ◽

pp. 467-475 ◽

Cited By ~ 2

Author(s):

Su-wei Gao ◽

Feng Liu

Keyword(s):

Cell Cycle ◽

Cell Fate ◽

Cell Cycle Regulation ◽

Cell Fate Determination ◽

Fate Determination ◽

Cycle Regulation

Download Full-text

Life after meiosis: patterning the angiosperm male gametophyte

Biochemical Society Transactions ◽

10.1042/bst0380577 ◽

2010 ◽

Vol 38 (2) ◽

pp. 577-582 ◽

Cited By ~ 22

Author(s):

Michael Borg ◽

David Twell

Keyword(s):

Cell Cycle ◽

Cell Fate ◽

Cell Cycle Progression ◽

Male Gametophyte ◽

Cell Fate Determination ◽

Double Fertilization ◽

Cycle Progression ◽

Fate Determination ◽

Male Gametogenesis ◽

The Impact

Pollen grains represent the highly reduced haploid male gametophyte generation in angiosperms. They play an essential role in plant fertility by generating and delivering twin sperm cells to the embryo sac to undergo double fertilization. The functional specialization of the male gametophyte and double fertilization are considered to be key innovations in the evolutionary success of angiosperms. The haploid nature of the male gametophyte and its highly tractable ontogeny makes it an attractive system to study many fundamental biological processes, such as cell fate determination, cell-cycle progression and gene regulation. The present mini-review encompasses key advances in our understanding of the molecular mechanisms controlling male gametophyte patterning in angiosperms. A brief overview of male gametophyte development is presented, followed by a discussion of the genes required at landmark events of male gametogenesis. The value of the male gametophyte as an experimental system to study the interplay between cell fate determination and cell-cycle progression is also discussed and exemplified with an emerging model outlining the regulatory networks that distinguish the fate of the male germline from its sister vegetative cell. We conclude with a perspective of the impact emerging data will have on future research strategies and how they will develop further our understanding of male gametogenesis and plant development.

Download Full-text