Effect of surfactant mixtures on irritant dermatitis potential in man: Sodium lauroyl glutamate and sodium lauryl sulphate

Equilibrium vesicles, those which are the stable form of aggregation and form spontaneously on mixing surfactant with water, have never been demonstrated in single component bilayers and only rarely in lipid or surfactant mixtures. Designing a simple and general method for producing spontaneous and stable vesicles depends on a better understanding of the thermodynamics of aggregation, the interplay of intermolecular forces in surfactants, and an efficient way of doing structural characterization in dynamic systems.

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NATURAL COSMETICS IN THE CARE OF YOUNG CHILDREN

PEDIATRIA Journal named after G N SPERANSKY ◽

10.24110/0031-403x-2020-99-6-155-162 ◽

2020 ◽

Vol 99 (6) ◽

pp. 155-162

Author(s):

O.B. Tamrazova ◽

◽

S.P. Seleznev ◽

A.V. Tamrazova ◽

◽

...

Keyword(s):

Skin Barrier ◽

Structural Features ◽

Transepidermal Water Loss ◽

General Information ◽

Skin Barrier Function ◽

Skin Physiology ◽

Main Emphasis ◽

Antimicrobial Protection ◽

Irritant Dermatitis ◽

Adaptive Shifts

The article provides general information about the skin physiology of newborns and infants. Structural features of the skin and main adaptive shifts in newborns, are described. Тhe child has an increase in the skin barrier function of the skin, which prevents transepidermal water loss; active synthesis of natural moisturizing factor (NMF) components that control skin hydration; shift of pH to acidic environment; normalization of thermoregulatory functions; enhancement of the photoprotective function; immune restructuring for antimicrobial protection; formation of a normal microbiome. The article describes the consequences of improper skin care of a newborn, using the example of diaper dermatitis, irritant dermatitis, prickly heat and vesiculopustulosis. The importance of using specialized children's cosmetics in caring for an infant is assessed. The basic recommendations for the choice of these products are presented, where the main emphasis is on the choice of products consisting of natural ingredients. Giving preference to natural cosmetics, everyone should carefully study the composition of these products and trust the manufacturers who can guarantee safety of care products for the youngest children.

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Solubilization of Itraconazole by Surfactants and Phospholipid-Surfactant Mixtures: Interplay of Amphiphile Structure, pH and Electrostatic Interactions

10.26434/chemrxiv.12038682 ◽

2020 ◽

Author(s):

Zahari Vinarov ◽

Gabriela Gancheva ◽

Nikola Burdzhiev ◽

Slavka S. Tcholakova

Keyword(s):

Nmr Spectroscopy ◽

Electrostatic Interactions ◽

Triazole Ring ◽

Water Soluble ◽

Single Chain ◽

Surfactant Mixtures ◽

Solubilization Capacity ◽

Water Soluble Drugs ◽

Hydrophobic Chain ◽

Brick Dust

Although surfactants are frequently used in enabling formulations of poorly water-soluble drugs, the link between their structure and drug solubilization capacity is still unclear. We studied the solubilization of the “brick-dust” molecule itraconazole by 16 surfactants and 3 phospholipid:surfactant mixtures. NMR spectroscopy was used to study in more details the drug-surfactant interactions. Very high solubility of itraconazole (up to 3.6 g/L) was measured in anionic surfactant micelles at pH = 3, due to electrostatic attraction between the oppositely charged (at this pH) drug and surfactant molecules. <sup>1</sup>H NMR spectroscopy showed that itraconazole is ionized at two sites (2+ charge) at these conditions: in the phenoxy-linked piperazine nitrogen and in the dioxolane-linked triazole ring. The increase of amphiphile hydrophobic chain length had a markedly different effect, depending on the amphiphile type: the solubilization capacity of single-chain surfactants increased, whereas a decrease was observed for double-chained surfactants (phosphatidylglycerols). The excellent correlation between the chain melting temperatures of phosphatidylglycerols and itraconazole solubilization illustrated the importance of hydrophobic chain mobility. This study provides rules for selection of itraconazole solubilizers among classical single-chain surfactants and phospholipids. The basic physics underpinning the described effects suggests that these rules should be transferrable to other “brick-dust” molecules.

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Research of Binary Surfactant Mixtures Based on N-Lauroyl Sarcosinate

Tenside Surfactants Detergents ◽

10.3139/113.110567 ◽

2018 ◽

Vol 55 (4) ◽

pp. 294-301 ◽

Cited By ~ 1

Author(s):

Juan Cui ◽

Hujun Xu

Keyword(s):

Surfactant Mixtures ◽

Lauroyl Sarcosinate

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Coadsorption of bulky ions by surfactants. Monomolecular layers of tris(2,2'-bipyridyl)ruthenium(II) complex with sodium lauryl sulphate on glassy carbon, platinium, n-SnO2, and n-Si electrodes

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19842187 ◽

1984 ◽

Vol 49 (10) ◽

pp. 2187-2196 ◽

Cited By ~ 1

Author(s):

Jan Lasovský ◽

František Grambal ◽

Miroslav Rypka

Keyword(s):

Glassy Carbon ◽

Complex Cation ◽

Radiant Energy ◽

Electric Energy ◽

Sodium Lauryl Sulphate ◽

Surface Films ◽

Order Of Magnitude ◽

Monomolecular Layers ◽

Self Association ◽

Semiconductor Electrodes

The electrochemical and photochemical behaviour of tris(2,2'-bipyridyl)ruthenium(II) complex (I) on glassy carbon, platinium, n-SnO2, and n-Si electrodes in the presence of sodium lauryl sulphate (II) was investigated. The surfactant in low concentrations induces self-association of the complex cation and its accumulation in the electrode-solution interface. At the optimum concentrations of sodium lauryl sulphate (cII ~0.6 mmol l-1) and of the complex (cI < 0.1 mmol l-1), monomolecular layers composed of I, II counterions are formed on the electrodes. The formation of the surface films does not depend on the kind of the electrode and improves the sensitivity of the voltammetric determination of I by as much as an order of magnitude. For the semiconductor electrodes, the surface films enhance the efficiency of conversion of radiant energy into electric energy. The effect under study may participate in the photosynthesis of green plants.

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